Limit of detection in the presence of instrumental and non-instrumental errors: study of the possible sources of error and application to the analysis of 41 elements at trace levels by inductively coupled plasma-mass spectrometry technique

In recent years, radionuclide monitoring and contamination control have been attached great importance. Wide attention has been paid to the measurement and analysis of Neptunium (237Np) as one of the radio-nuclides. With the development of mass-spectrometry technique, the inductively coupled plasma-mass spectrometry (ICP-MS) technique, with its outstanding advantage, has been widely applied to the measurement of237Np in environmental and biological samples. In this paper, the progress in analysis of237Np in environmental samples with ICP-MS technique is overviewed.

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U-Pb isotope geochronology of zircon: evaluation of the laser probe-inductively coupled plasma mass spectrometry technique

Geochimica et Cosmochimica Acta ◽

10.1016/0016-7037(95)00144-1 ◽

1995 ◽

Vol 59 (12) ◽

pp. 2491-2500 ◽

Cited By ~ 224

Author(s):

Takafumi Hirata ◽

Robert W. Nesbitt

Keyword(s):

Mass Spectrometry ◽

Inductively Coupled Plasma ◽

Pb Isotope ◽

Isotope Geochronology ◽

Laser Probe ◽

Inductively Coupled ◽

Mass Spectrometry Technique ◽

Plasma Mass Spectrometry ◽

Spectrometry Technique

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Short-term ingestion of chlorogenic or caffeic acids decreases zinc but not copper absorption in rats, utilization of stable isotopes and inductively-coupled plasma mass spectrometry technique

British Journal Of Nutrition ◽

10.1017/s0007114598001676 ◽

1998 ◽

Vol 80 (6) ◽

pp. 575-584 ◽

Cited By ~ 31

Author(s):

Charles Coudray ◽

Carole Bousset ◽

Jean C. Tressol ◽

Denise Pépin ◽

Yves Rayssiguier

Keyword(s):

Mass Spectrometry ◽

Stable Isotopes ◽

Trace Elements ◽

Chlorogenic Acid ◽

Inductively Coupled Plasma ◽

Control Group ◽

Inductively Coupled ◽

Mass Spectrometry Technique ◽

Plasma Mass Spectrometry ◽

Spectrometry Technique

The amount of dietary trace elements absorbed from a meal depends, among other factors, on the quantities of certain minor plant constituents present in the meal. These substances can act as ligands and bind trace elements in the digestive tract in available or unavailable forms for absorption. The present study was designed to investigate the extent to which different polyphenols (PP) may influence Zn and Cu absorption in rats. Different PP of nutritional interest (chlorogenic acid, caffeic acid, catechin and rutin) were studied using meals extrinsically-labelled with stable isotopes67Zn and 65Cu. Male Wistar rats were fed on a non-labelled semi-synthetic diet containing (mg/kg) 38 Fe, 35 Zn and 7·5 Cu for 8 d. PP were dissolved in dimethyl sulfoxide as the solvent and added to the meal at 1 g/kg during 3 d before isotope administration and until the end of the experiment (a further 3 d). The control group received the dimethyl sulfoxide only. After overnight food deprivation, rats were fed on the labelled test meals (4 g diet+0·1 mg 67Zn and 0·1 mg 65Cu) with 0·5 mg Dy as a faecal marker. Faeces and urine pools were collected for 3 d and analysed for 67Zn and65 Cu isotopic enrichment using the inductively-coupled plasma mass spectrometry technique. Zn absorption was significantly less in rats fed on chlorogenic acid or caffeic acid than in the control group. Catechin ingestion non-significantly inhibited 67Zn absorption. However, the PP studied were without effect on Cu absorption. The study illustrates the effect of metal-binding phenolic compounds on mineral nutrition in the rat, and the possible importance of the effects of different foods rich in these compounds on mineral absorption in man.

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Simultaneous Analysis of Cadmium, Lead, Mercury, and Arsenic Content in Foodstuffs of Animal Origin by Inductively Coupled Plasma/Mass Spectrometry after Closed Vessel Microwave Digestion: Method Validation

Journal of AOAC International ◽

10.1093/jaoac/88.6.1811 ◽

2005 ◽

Vol 88 (6) ◽

pp. 1811-1821 ◽

Cited By ~ 32

Author(s):

Laurent Noël ◽

Vincent Dufailly ◽

Nadège Lemahieu ◽

Christelle Vastel ◽

Thierry Guérin

Keyword(s):

Mass Spectrometry ◽

Method Validation ◽

Inductively Coupled Plasma ◽

Limit Of Detection ◽

Microwave Digestion ◽

Animal Origin ◽

Closed Vessel ◽

Inductively Coupled ◽

Icp Ms ◽

Plasma Mass Spectrometry

Abstract A method validation of the total analysis of cadmium (Cd), lead (Pb), arsenic (As), and mercury (Hg) in foodstuffs by inductively coupled plasma/mass spectrometry (ICP/MS) after closed vessel microwave digestion is presented. Due to the lack of reference method for ICP/MS techniques in food and, based on the project of the European Committee of Normalization (CEN/TC 275/WG 10), the Agence Française de Normalisation (AFNOR) guidelines NF V03–110 were used for the evaluation of this method based on 2 steps, sample preparation and multielement detection. Several criteria considered as compulsory (linearity, specificity, precision under repeatability conditions, and trueness) have been estimated and discussed, in addition to intermediate precision reproducibility, the limit of detection, and the limit of quantification. Furthermore, a comparison with in-house methods using electrothermal atomic absorption was performed using an external proficiency testing scheme and food samples. The results indicated that this method could be used in the laboratory for the routine determination of these 4 cumulative toxic metals in foodstuffs with acceptable analytical performance.

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