Near Infrared Spectroscopy (NIRS): A Pilot Study to Measure Hemoglobin Concentration Changes in the Brains of Persons who Stutter and Typically Fluent Speakers

Although functional near-infrared spectroscopy (fNIRS) has been developing as a useful tool for monitoring functional brain activity since the early 1990s, the quantification of hemoglobin concentration changes is still controversial and there are few detailed reports especially for continuous-wave (CW) instruments. By means of a two-layer model experiment mimicking hemodynamic changes in brain and mathematical analysis based on the modified Beer-Lambert law, we established an algorithm for a CW functional near-infrared spectroscopy (CW-fNIRS). The accuracy of this algorithm was validated both in comparison with direct measurements on brain tissue model and in vivo measurement upon human valsalva maneuver. This described method can also be utilized for other CW-fNIRS instruments to establish measuring algorithm.

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Measuring speaker-listener neural coupling with functional near infrared spectroscopy

10.1101/081166 ◽

2016 ◽

Author(s):

Yichuan Liu ◽

Elise A. Piazza ◽

Erez Simony ◽

Patricia A. Shewokis ◽

Banu Onaral ◽

...

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Brain Activity ◽

Hemoglobin Concentration ◽

Verbal Communication ◽

Story Comprehension ◽

Speech Comprehension ◽

Functional Near Infrared Spectroscopy ◽

Concentration Changes

AbstractThe present study investigates brain-to-brain coupling, defined as inter-subject correlations in the hemodynamic response, during natural verbal communication. We used functional near-infrared spectroscopy (fNIRS) to record brain activity of speakers telling stories and listeners comprehending audio recordings of these stories. Listeners’ brain activity was correlated with speakers’ with a delay. This between-brain correlation disappeared when verbal communication failed. We further compared the fNIRS and functional Magnetic Resonance Imaging (fMRI) recordings of listeners comprehending the same story and found a relationship between the fNIRS oxygenated-hemoglobin concentration changes and the fMRI BOLD in brain areas associated with speech comprehension. This correlation between fNIRS and fMRI was only present when data from the same story were compared between the two modalities and vanished when data from different stories were compared; this cross-modality consistency further highlights the reliability of the spatiotemporal brain activation pattern as a measure of story comprehension. Our findings suggest that fNIRS is a powerful tool for investigating brain-to-brain coupling during verbal communication. As fNIRS sensors are relatively low-cost and can even be built into wireless, portable, battery-operated systems, these results highlight the potential of broad utilization of this approach in everyday settings for augmenting communication and interaction.

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Cortical hemoglobin-concentration changes under the coil induced by single-pulse TMS in humans: a simultaneous recording with near-infrared spectroscopy

Experimental Brain Research ◽

10.1007/s00221-005-0149-0 ◽

2005 ◽

Vol 169 (3) ◽

pp. 302-310 ◽

Cited By ~ 38

Author(s):

Hitoshi Mochizuki ◽

Yoshikazu Ugawa ◽

Yasuo Terao ◽

Kuniyoshi L. Sakai

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Single Pulse ◽

Simultaneous Recording ◽

Concentration Changes

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Design of a wearable four-channel near-infrared spectroscopy system for the measurement of brain hemodynamic responses

Biomedical Engineering / Biomedizinische Technik ◽

10.1515/bmt-2019-0291 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Janani Arivudaiyanambi ◽

Sasikala Mohan ◽

Sunaina Mariam Cherian ◽

Kumaravel Natesan

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Motor Execution ◽

Hemodynamic Changes ◽

Hemodynamic Responses ◽

Concentration Changes ◽

Spectroscopy System ◽

The Brain

AbstractObjectivesThis work describes the design and development of a four-channel near-infrared spectroscopy system to detect the oxygenated and deoxygenated hemoglobin concentration changes in the brain during various motor tasks.MethodsThe system uses light-emitting diodes corresponding to two wavelengths of 760 nm and 850 nm sensitive to deoxygenated and oxygenated hemoglobin concentration changes, respectively. The response is detected using a photodetector with an integrated transimpedance amplifier. The system is designed with four channels for functional near-infrared spectroscopy (fNIRS) signals acquisition. Two experiments were conducted to demonstrate the ability of the system to detect the changes in hemodynamic responses of different tasks. In the first experiment, the hemodynamic changes during motor execution and imagery of right- and left-fist clenching tasks were acquired by the developed system and validated against a standard multichannel NIRS system. In another experiment, the fNIRS signals during rest and motor execution of right-fist clenching task were acquired using the system and classified.ResultsThe results demonstrate the ability of the designed system to detect the brain hemodynamic changes during various tasks. Also, the activation patterns obtained by the developed system with a minimum number of channels are on par with those obtained by the commercial system.ConclusionsThe developed four-channel NIRS system is user-friendly and has been designed with inexpensive components, unlike the commercially available NIRS instruments that are cumbersome and expensive.

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Measuring Real-Time Physiological Changes by near Infrared Spectroscopy

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.687-691.974 ◽

2014 ◽

Vol 687-691 ◽

pp. 974-977

Author(s):

Yu Xiang Wu ◽

Min Fang Huang ◽

Tao Song ◽

Guo Dong Xu

Keyword(s):

Infrared Spectroscopy ◽

Real Time ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Muscle Oxygen ◽

Sport Training ◽

Concentration Changes ◽

Oxygen Monitoring ◽

Scientific Fields

Near infrared spectroscopy is a promising technique in many scientific fields, but it is still a new measurement in sport science, of which coaches and athletes cannot make good use. In this paper we demonstrate how the real-time physiological oxygenated hemoglobin and deoxygenated hemoglobin concentration changes in the muscle can be measured noninvasively by near infrared spectroscopy and explain what the advantages of it is. The purpose is to reveal the mechanism and potential of muscle oxygen monitoring, which may play an important role in sport training.

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Maps of cerebral hemoglobin concentration changes obtained by near-infrared spectroscopy. Characterization of phase shifts among locations

Biomedical Optical Spectroscopy and Diagnostics ◽

10.1364/bosd.2000.tuf6 ◽

2000 ◽

Author(s):

Martin Wolf ◽

Vlad Toronov ◽

Ursula Wolf ◽

L. Adelina Paunescu ◽

Antonios Michalos ◽

...

Keyword(s):

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Phase Shifts ◽

Concentration Changes

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Prediction of anastomotic leakage after left-sided colorectal cancer surgery: a pilot study utilizing quantitative near-infrared spectroscopy

Surgery Today ◽

10.1007/s00595-021-02426-y ◽

2022 ◽

Author(s):

Hisaaki Yoshinaka ◽

Yuji Takakura ◽

Hiroyuki Egi ◽

Wataru Shimizu ◽

Yusuke Sumi ◽

...

Keyword(s):

Colorectal Cancer ◽

Infrared Spectroscopy ◽

Pilot Study ◽

Anastomotic Leakage ◽

Near Infrared Spectroscopy ◽

Near Infrared ◽

Cancer Surgery ◽

Colorectal Cancer Surgery

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Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets

Journal of Applied Physiology ◽

10.1152/japplphysiol.00830.2005 ◽

2006 ◽

Vol 100 (3) ◽

pp. 850-857 ◽

Cited By ~ 31

Author(s):

Kenneth M. Tichauer ◽

Derek W. Brown ◽

Jennifer Hadway ◽

Ting-Yim Lee ◽

Keith St. Lawrence

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Infrared Spectroscopy ◽

Near Infrared Spectroscopy ◽

Neonatal Intensive Care ◽

Near Infrared ◽

Hemoglobin Concentration ◽

Oxygen Extraction Fraction ◽

Newborn Piglets ◽

Hypoxia Ischemia

Impaired oxidative metabolism following hypoxia-ischemia (HI) is believed to be an early indicator of delayed brain injury. The cerebral metabolic rate of oxygen (CMRO2) can be measured by combining near-infrared spectroscopy (NIRS) measurements of cerebral blood flow (CBF) and cerebral deoxy-hemoglobin concentration. The ability of NIRS to measure changes in CMRO2 following HI was investigated in newborn piglets. Nine piglets were subjected to 30 min of HI by occluding both carotid arteries and reducing the fraction of inspired oxygen to 8%. An additional nine piglets served as sham-operated controls. Measurements of CBF, oxygen extraction fraction (OEF), and CMRO2 were obtained at baseline and at 6 h after the HI insult. Of the three parameters, only CMRO2 showed a persistent and significant change after HI. Five minutes after reoxygenation, there was a 28 ± 12% (mean ± SE) decrease in CMRO2, a 72 ± 50% increase in CBF, and a 56 ± 19% decrease in OEF compared with baseline ( P < 0.05). By 30 min postinsult and for the remainder of the study, there were no significant differences in CBF and OEF between control and insult groups, whereas CMRO2 remained depressed throughout the 6-h postinsult period. This study demonstrates that NIRS can measure decreases in CMRO2 caused by HI. The results highlight the potential for NIRS to be used in the neonatal intensive care unit to detect delayed brain damage.

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