Acute effects of Δ9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativity

Abstract. Playing a musical instrument professionally has been shown to lead to structural and functional neural adaptations, making musicians valuable subjects for neuroplasticity research. Here, we follow the hypothesis that specific musical demands further shape neural processing. To test this assumption, we subjected groups of professional drummers, professional woodwind players, and nonmusicians to pure tone sequences and drum sequences in which infrequent anticipations of tones or drum beats had been inserted. Passively listening to these sequences elicited a mismatch negativity to the temporally deviant stimuli which was greater in the musicians for tone series and particularly large for drummers for drum sequences. In active listening conditions drummers more accurately and more quickly detected temporally deviant stimuli.

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Effects of Experimentally Induced Pain on Mismatch Negativity

Journal of Psychophysiology ◽

10.1027/0269-8803.20.1.21 ◽

2006 ◽

Vol 20 (1) ◽

pp. 21-31 ◽

Cited By ~ 6

Author(s):

Bruce D. Dick ◽

John F. Connolly ◽

Michael E. Houlihan ◽

Patrick J. McGrath ◽

G. Allen Finley ◽

...

Keyword(s):

Cognitive Processing ◽

Mismatch Negativity ◽

Event Related Potentials ◽

Disruptive Effect ◽

Ischemic Pain ◽

Active Attention ◽

Early Processing ◽

Related Potentials ◽

Healthy Participants ◽

Experimentally Induced

Abstract: Previous research has found that pain can exert a disruptive effect on cognitive processing. This experiment was conducted to extend previous research with participants with chronic pain. This report examines pain's effects on early processing of auditory stimulus differences using the Mismatch Negativity (MMN) in healthy participants while they experienced experimentally induced pain. Event-related potentials (ERPs) were recorded using target and standard tones whose pitch differences were easy- or difficult-to-detect in conditions where participants attended to (active attention) or ignored (passive attention) the stimuli. Both attention manipulations were conducted in no pain and pain conditions. Experimentally induced ischemic pain did not disrupt the MMN. However, MMN amplitudes were larger to difficult-to-detect deviant tones during painful stimulation when they were attended than when they were ignored. Also, MMN amplitudes were larger to the difficult- than to the easy-to-detect tones in the active attention condition regardless of pain condition. It appears that rather than exerting a disruptive effect, the presence of experimentally induced pain enhanced early processing of small stimulus differences in these healthy participants.

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Human Event-Related Potentials to Higher-Order Acoustic Spatial Changes

Journal of Psychophysiology ◽

10.1027//0269-8803.16.2.114 ◽

2002 ◽

Vol 16 (2) ◽

pp. 114-118 ◽

Cited By ~ 1

Author(s):

Timo Ruusuvirta ◽

Heikki Hämäläinen

Keyword(s):

Working Memory ◽

Mismatch Negativity ◽

Spatial Information ◽

Free Field ◽

Event Related Potentials ◽

Negative Polarity ◽

Positive Polarity ◽

Spatial Changes ◽

Related Potentials ◽

Human Event

Abstract Human event-related potentials (ERPs) to a tone continuously alternating between its two spatial loci of origin (middle-standards, left-standards), to repetitions of left-standards (oddball-deviants), and to the tones originally representing these repetitions presented alone (alone-deviants) were recorded in free-field conditions. During the recordings (Fz, Cz, Pz, M1, and M2 referenced to nose), the subjects watched a silent movie. Oddball-deviants elicited a spatially diffuse two-peaked deflection of positive polarity. It differed from a deflection elicited by left-standards and commenced earlier than a prominent deflection of negative polarity (N1) elicited by alone-deviants. The results are discussed in the context of the mismatch negativity (MMN) and previous findings of dissociation between spatial and non-spatial information in auditory working memory.

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