Gene-environment interaction as a predictor of early adjustment in first episode psychosis

2017 ◽  
Vol 189 ◽  
pp. 196-203 ◽  
Author(s):  
David Fraguas ◽  
Covadonga M. Díaz-Caneja ◽  
Iluminada Corripio ◽  
Ana González-Pinto ◽  
Antonio Lobo ◽  
...  
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Gene Environment Interaction ◽  
Gene Environment ◽  
Episode Psychosis

scholarly journals The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

2020 ◽  
Author(s):  
Tiziano De Matteis ◽  
Giuseppe D'Andrea ◽  
Jatin Lal ◽  
Domenico Berardi ◽  
Ilaria Tarricone
Keyword(s):  
Incidence Study ◽  
Catchment Area ◽  
Maternal Education ◽  
Health Centre ◽  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Episode Psychosis ◽  
Study Results ◽  
The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

scholarly journals The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

2020 ◽  
Author(s):  
Tiziano De Matteis ◽  
Giuseppe D'Andrea ◽  
Jatin Lal ◽  
Domenico Berardi ◽  
Ilaria Tarricone
Keyword(s):  
Incidence Study ◽  
Catchment Area ◽  
Maternal Education ◽  
Health Centre ◽  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Episode Psychosis ◽  
Study Results ◽  
The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

scholarly journals The impact of peri-natal stress on psychosis risk: results from the Bo-FEP incidence study

2020 ◽  
Author(s):  
Tiziano De Matteis ◽  
Giuseppe D'Andrea ◽  
Jatin Lal ◽  
Domenico Berardi ◽  
Ilaria Tarricone
Keyword(s):  
Incidence Study ◽  
Catchment Area ◽  
Maternal Education ◽  
Health Centre ◽  
First Episode Psychosis ◽  
First Episode ◽  
Environment Interaction ◽  
Episode Psychosis ◽  
Study Results ◽  
The Impact

Abstract Objective: According to the gene-environment interaction model the pathogenesis of psychosis relies on an adverse neuro-socio-developmental pathway. Perinatal stress represents an important risk factor for the development of psychosis because of the increasingly evident interference with socio-neuro-development in the earlier phases of life. We aim to investigate the correlation of perinatal risk factors with the onset of psychosis with a case-control – incidence study. Results: Patients (and their mothers) were eligible if they presented with first-episode psychosis at the Bologna West Community Mental Health Centre (Bo-West CMHC) between 2002 and 2012. The Bo-West CMHC serves a catchment area of about 200,000 people. The controls were recruited in the same catchment area and study period. 42 patients, 26 controls and their mothers were included. We collected the history of peri-natal stress and calculated crude and adjusted Odds Ratios for onset of first-episode psychosis. Adjusted logistic regression showed that psychosis onset was significantly associated with stressful situations during pregnancy, lower level of maternal physical health before or during pregnancy, use of anti-inflammatory drugs during pregnancy, and low level of maternal education. The results of our study suggest that stress during perinatal period increases the risk of developing psychosis.

The Cavan-Monaghan First Episode Psychosis Study (CAMFEPS): arbitrary diagnostic boundaries across the gene–environment interface and within evolving models of care

2019 ◽  
Vol 36 (4) ◽  
pp. 293-303 ◽  
Author(s):  
John L. Waddington ◽  
Vincent Russell
Keyword(s):  
Evidence Base ◽  
First Episode Psychosis ◽  
Models Of Care ◽  
First Episode ◽  
Psychotic Illness ◽  
Gene Environment ◽  
Episode Psychosis ◽  
Normal Human ◽  
New Generation ◽  
Evolving Models

As research into psychotic illness evolves along established lines, insights are emerging that deviate from those lines and challenge more fundamentally our understanding. On the background of a new generation of studies on first-episode psychosis, investigations across the gene–environment interface and the intersection with ‘normal’ human mentation heighten these concerns. Using findings from the Cavan-Monaghan First Episode Psychosis Study (CAMFEPS) as an exemplar, we here review the complexity of these challenges from the perspective of this real-world setting. They range from trans-diagnostic epidemiology and clinical characterisation, through molecular genetics, social milieu, developmental pathobiology and functional outcome across arbitrary diagnostic boundaries, to the evidence base for early intervention and more radical conceptualisations and structures for provision of mental health care.

Gene-Environment Interactions Underlying the Effect of Cannabis in First Episode Psychosis

2012 ◽  
Vol 18 (32) ◽  
pp. 5024-5035 ◽  
Author(s):  
Jose Maria Pelayo-Teran ◽  
Paula Suarez-Pinilla ◽  
Nicholas Chadi ◽  
Benedicto Crespo-Facorro
Keyword(s):  
First Episode Psychosis ◽  
First Episode ◽  
Gene Environment ◽  
Episode Psychosis
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