scholarly journals Sex differences in distributed error-related neural activation in binge drinking young adults

2021 ◽  
Author(s):  
Jillian E Hardee ◽  
Alexander Samuel Weigard ◽  
Mary Heitzeg ◽  
Meghan E. Martz ◽  
Lora M. Cope
Keyword(s):  
Substance Use ◽  
Sex Differences ◽  
Cognitive Control ◽  
Binge Drinking ◽  
Anterior Cingulate Cortex ◽  
Linear Regression Analysis ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Neural Activation ◽  
Summary Measure

Detecting and responding to errors is central to goal-directed behavior and cognitive control, which are thought to be supported by a network of structures that includes the anterior cingulate cortex and anterior insula. Notable sex differences in the maturational timing of cognitive control neural systems create differential periods of vulnerability for psychiatric conditions, such as substance use disorders, between males and females. Here we examined sex differences in error-related activation across an array of distributed brain regions during a go/no-go task in a sample of binge drinking college students. Regions of interest previously linked to error-related activation, including the anterior cingulate cortex, insula, and frontoparietal structures, were selected in a term-based meta-analysis and individual differences in their activation were indexed using a multivariate summary measure. Males exhibited significantly higher levels of this multivariate summary measure than females. Males also reported significantly greater substance use; however, substance use did not significantly predict neural activation in a linear regression analysis. These findings suggest that males have more marked responses to errors across a network of regions linked to performance monitoring and cognitive control.

Anterior cingulate cortex glutamate and its association with striatal functioning during cognitive control

2018 ◽  
Vol 28 (3) ◽  
pp. 381-391 ◽  
Author(s):  
Jilly Naaijen ◽  
David J. Lythgoe ◽  
Marcel P. Zwiers ◽  
Catharina A. Hartman ◽  
Pieter J. Hoekstra ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate

scholarly journals Sex differences in DEK expression in the anterior cingulate cortex and its association with dementia severity in schizophrenia

2018 ◽  
Vol 202 ◽  
pp. 188-194 ◽  
Author(s):  
Sinead M. O'Donovan ◽  
Ana Franco-Villanueva ◽  
Valentina Ghisays ◽  
Jody L. Caldwell ◽  
Vahraim Haroutunian ◽  
...  
Keyword(s):  
Sex Differences ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Dementia Severity

scholarly journals Cognitive Control in Late-Life Depression: Response Inhibition Deficits and Dysfunction of the Anterior Cingulate Cortex

2010 ◽  
Vol 18 (11) ◽  
pp. 1017-1025 ◽  
Author(s):  
Richard Katz ◽  
Pierfilippo De Sanctis ◽  
Jeannette R. Mahoney ◽  
Pejman Sehatpour ◽  
Christopher F. Murphy ◽  
...  
Keyword(s):  
Cognitive Control ◽  
Anterior Cingulate Cortex ◽  
Response Inhibition ◽  
Late Life ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Late Life Depression

scholarly journals Resting-state theta oscillations and reward sensitivity in risk taking

2021 ◽  
Author(s):  
Maria Azanova ◽  
Maria Herrojo Ruiz ◽  
Alexis V. Belianin ◽  
Vasily Klucharev ◽  
Vadim V. Nikulin
Keyword(s):  
Sex Differences ◽  
Anterior Cingulate Cortex ◽  
Risk Taking ◽  
Resting State ◽  
Cingulate Cortex ◽  
Reward Sensitivity ◽  
Anterior Cingulate ◽  
Theta Oscillations ◽  
Theta Power ◽  
Reward And Punishment

AbstractFemales demonstrate greater risk aversion than males on a variety of tasks, but the underlying neurobiological basis is still unclear. We studied how theta (4-7 Hz) oscillations at rest related to three different measures of risk taking. Thirty-five participants (15 females) completed the Bomb Risk Elicitation Task (BRET), which allowed us to measure risk taking during an economic game. The Domain-Specific Risk-Taking Scale (DOSPERT) was used to measure self-assessed risk attitudes as well as reward and punishment sensitivities. In addition, the Barratt Impulsiveness Scale (BIS11) was included to quantify impulsiveness. To obtain measures of frontal theta asymmetry and frontal theta power, we used magnetoencephalography (MEG) acquired prior to task completion, while participants were at rest. Frontal theta asymmetry correlated with average risk taking during the game but only in the female sample. By contrast, frontal theta power correlated with risk taking as well as with measures of reward and punishment sensitivity in the joint sample. Importantly, we showed that reward sensitivity mediated a correlation between risk taking and the power of theta oscillations localized to the anterior cingulate cortex. In addition, we observed significant sex differences in source- and sensor-space theta power, risk taking during the game, and reward sensitivity. Our findings suggest that sensitivity to rewards, associated with resting-state theta oscillations in the anterior cingulate cortex, is a trait that potentially contributes to sex differences in risk taking.

scholarly journals Childhood adversity, externalizing behavior, and substance use in adolescence: Mediating effects of anterior cingulate cortex activation during inhibitory errors

2018 ◽  
Vol 31 (04) ◽  
pp. 1439-1450 ◽  
Author(s):  
Nicole M. Fava ◽  
Elisa M. Trucco ◽  
Meghan E. Martz ◽  
Lora M. Cope ◽  
Jennifer M. Jester ◽  
...  
Keyword(s):  
Substance Use ◽  
Problem Behavior ◽  
Anterior Cingulate Cortex ◽  
Inhibitory Control ◽  
Externalizing Behavior ◽  
Childhood Adversity ◽  
Cingulate Cortex ◽  
Late Adolescence ◽  
Anterior Cingulate ◽  
Early Adolescent

AbstractChildhood adversity can negatively impact development across various domains, including physical and mental health. Adverse childhood experiences have been linked to aggression and substance use; however, developmental pathways to explain these associations are not well characterized. Understanding early precursors to later problem behavior and substance use can inform preventive interventions. The aim of the current study was to examine neurobiological pathways through which childhood adversity may lead to early adolescent problem behavior and substance use in late adolescence by testing two prospective models. Our first model found that early adolescent externalizing behavior mediates the association between childhood adversity and alcohol, cigarette, and marijuana use in late adolescence. Our second model found that activation in the anterior cingulate cortex (ACC) during an inhibitory control task mediates the association between childhood adversity and early adolescent externalizing behavior, with lower ACC activation associated with higher levels of adversity and more externalizing behavior. Together these findings indicate that the path to substance use in late adolescence from childhood adversity may operate through lower functioning in the ACC related to inhibitory control and externalizing behavior. Early life stressors should be considered an integral component in the etiology and prevention of early and problematic substance use.

Sign in / Sign up

Export Citation Format

Share Document