scholarly journals Mortality and non-use of antipsychotic drugs after acute admission in schizophrenia: A prospective total-cohort study

2021 ◽  
Vol 235 ◽  
pp. 29-35
Author(s):  
Maria Fagerbakke Strømme ◽  
Liv Solrunn Mellesdal ◽  
Christoffer Bartz-Johannesen ◽  
Rune Andreas Kroken ◽  
Marianne Krogenes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Antipsychotic Drugs ◽  
Acute Admission ◽  
Total Cohort

Antipsychotic drugs and short-term mortality after peptic ulcer perforation: a population-based cohort study

2008 ◽  
Vol 28 (7) ◽  
pp. 895-902 ◽  
Author(s):  
C. CHRISTIANSEN ◽  
S. CHRISTENSEN ◽  
A. RIIS ◽  
R. W. THOMSEN ◽  
S. P. JOHNSEN ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Cohort Study ◽  
Antipsychotic Drugs ◽  
Population Based ◽  
Peptic Ulcer Perforation ◽  
Short Term ◽  
Ulcer Perforation ◽  
Short Term Mortality

scholarly journals Adherence to Antipsychotic Drugs by Medication Possession Ratio for Schizophrenia and Similar Psychotic Disorders in the Republic of Korea: A Retrospective Cohort Study

2020 ◽  
Author(s):  
Sung Joon Cho ◽  
Jungmee Kim ◽  
Jin Yong Lee ◽  
Jee Hoon Sohn
Keyword(s):  
Cohort Study ◽  
Hospital Admission ◽  
Psychiatric Hospital ◽  
Economic Burden ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Antipsychotic Drugs ◽  
Psychotic Disorders ◽  
Medication Possession Ratio ◽  
Medical Aid

Abstract Background: Pharmacotherapy is considered as an essential element in the treatment of schizophrenia and other psychotic disorders. Discontinuation of antipsychotic drugs increases medical use and economic burden, such as worsening of symptoms, recurrence, and hospitalization. Therefore, maintenance of drug treatment is essential to reduce the social burden caused by schizophrenia and SSP, and hence, it is important to analyze not only the incidence rate of the disorders, but also investigate the rate at which pharmacotherapy is maintained. Therefore, this study aimed to examine the current status of drug compliance using national health insurance data. Methods: This was a retrospective cohort study, which analyzed data from the nationwide insurance claims database. A total of 343,134 patients who were newly diagnosed with schizophrenia and schizophrenia similar psychosis (SSP) during 2011−2015. The adherence to antipsychotic drugs was assessed by medication possession ratio (MPR) and the risk factors of poor adherence were defined as MPR <40%.Results: The average of the MPRs among these patients was 45.8%, and the proportion of patients with less than 40% of MPR was 50.8%. It was found that female patients, the experience of “psychiatric hospital outpatient,” the experience of “psychiatric hospital admission,” the experience of “general hospital admission,” and patients receiving “medical aid” showed less risk of having statistically significant low MPR (< 40%).Conclusions: In this study, the drug adherence of schizophrenia and SSP patients currently under treatment, as estimated by MPR, was very low. However, it was also found that the MPR was high among patients receiving medical aid, with less medical expenses that they have to pay for themselves. Thus, it is possible to consider an institutional mechanism in which schizophrenia and SSP patients can be treated with less economic burden.

scholarly journals Combined Effect of Hypertension and Alcohol Consumption on the Risk of Death (27‑Year Cohort Prospective Study)

Kardiologiia ◽  
2021 ◽  
Vol 61 (1) ◽  
pp. 36-43
Author(s):  
I. V. Dolgalev ◽  
A. Yu. Ivanova ◽  
V. V. Obraztsov ◽  
I. V. Tsimbalyuk ◽  
R. S. Karpov
Keyword(s):  
Cohort Study ◽  
Alcohol Consumption ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Age Groups ◽  
Cardiovascular Death ◽  
Men And Women ◽  
Risk Of Death ◽  
Total Cohort ◽  
Alcohol Users

Aim      To study the effect of arterial hypertension (AH) in combination with frequent alcohol consumption on the formation of risk for cardiovascular death and all-cause death according to results of a 27-year prospective cohort study.Material and methods  This 27‑year prospective cohort study of an unorganized population of the Tomsk city (1546 people aged 20–59 years, including 630 men and 916 women) investigated AH prevalence and alcohol consumption (1988–1991) and analyzed the predictive significance of the effect of AH in combination with frequent alcohol consumption on the formation of risk for all-cause and cardiovascular death. AH was diagnosed at blood pressure ≥140 / 90 mm Hg. Frequent alcohol users were defined as those who consumed alcohol more than once a week.Results The combination of AH and frequent alcohol consumption increased the risk of all-cause death 4.1 times compared to that for persons without these risk factors (p<0.001). This was true for all age groups of the total cohort (higher relative risk, RR, was observed for persons aged 20–39 years) and for men (except for the group aged 40–59 years). RR of cardiovascular death was 5.3 (p<0.001) for frequent alcohol users with AH. It was established that frequent alcohol consumption additionally increased RR of all-cause death for persons with AH (RR 1.89; p<0.05) primarily at the expense of persons aged 20-39 years. Prediction of 27‑year survival for frequent alcohol users with AH was 35.3 %.Conclusion      A combination of AH with frequent alcohol consumption considerably increases the risk of all-cause and cardiovascular death. Frequent alcohol consumption significantly impairs the prediction of 27-year survival for persons with AH by additionally (1.9 times) increasing the risk of all-cause death. Binary AH combinations with frequent alcohol consumption exert a more pronounced adverse effect on young men and women.

scholarly journals Length of hospital stay after hip fracture and short term risk of death after discharge: a total cohort study in Sweden

BMJ ◽  
2015 ◽  
Vol 350 (feb20 1) ◽  
pp. h696-h696 ◽  
Author(s):  
P. Nordstrom ◽  
Y. Gustafson ◽  
K. Michaelsson ◽  
A. Nordstrom
Keyword(s):  
Cohort Study ◽  
Hip Fracture ◽  
Hospital Stay ◽  
Length Of Hospital Stay ◽  
Short Term ◽  
Risk Of Death ◽  
Total Cohort

scholarly journals TREATMENT WITH ANTIPSYCHOTICS AND RISK OF DEATH IN 58,000 PATIENTS FROM SWEDISH DEMENTIA REGISTRY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S421-S421
Author(s):  
Dorota Religa ◽  
Emilia Schwertner ◽  
sara Garcia-ptacek ◽  
Bjorn Johansson ◽  
Katarina Nägga ◽  
...  
Keyword(s):  
Antipsychotic Drugs ◽  
Psychological Symptoms ◽  
Dementia Diagnosis ◽  
Educational Effort ◽  
Risk Of Death ◽  
Total Cohort ◽  
Dementia Patients ◽  
All Cause Mortality ◽  
Dementia Registry ◽  
Behavioral And Psychological Symptoms

Abstract Background: Behavioral and Psychological symptoms of Dementia (BPSD) are a heterogeneous group of clinical phenomena that is subjectively experienced by the patient and/or observable by an examiner (e.g., caregiver, physician) consisting in disturbed emotions, perception, thought, motor activity, and altered personality. There are recommendations to limit antipsychotic use in patients with dementia, and the big educational effort is made to follow them. In Sweden antipsychotics use changed from 10.1% in 2007-2008 to 5.2% in 2014-2015. Aims: The aim of the study is to analyze the actors associated with treatment and mortality of dementia patients, particularly those suffering from BPSD. Particularly we focus on assessing all-cause mortality patients with dementia treated with antipsychotic drugs (APDs). Methods: We have analyzed 58,412 patients newly diagnosed with dementia. We have found that 2526 of the patients were prescribed APDs (602 typical APDs and 1833 atypical APDs)- Results In the adjusted models, use of APDs at the time of dementia diagnosis was associated with increased mortality risk in the total cohort (hazard ratio = 1.4; 95% confidence interval 1.3-1.5). We have also stratified the results. Conclusions: The risk of death in patients with dementia was increased in group that used atypical and typical APDs. Our study gives more evidence to advice caution in APD prescription for patients with dementia.

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