Alteration of neuro-dopamine and steroid hormone homeostasis in wild Bank voles in relation to tissue concentrations of PFAS at a Nordic skiing area

Peripheral tissue metabolism of steroids (intracrinology) is now accepted as a key way in which tissues, such as the endometrium, can utilize inactive steroids present in the blood to respond to local physiological demands and ‘fine-tune’ the activation or inhibition of steroid hormone receptor-dependent processes. Expression of enzymes that play a critical role in activation and inactivation of bioactive oestrogens (E1, E2) and androgens (A4, T, DHT), as well as expression of steroid hormone receptors, has been detected in endometrial tissues and cells recovered during the menstrual cycle. There is robust evidence that increased expression of aromatase is important for creating a local microenvironment that can support a pregnancy. Measurement of intra-tissue concentrations of steroids using liquid chromatography–tandem mass spectrometry has been important in advancing our understanding of a role for androgens in the endometrium acting both as active ligands for the androgen receptor and as substrates for oestrogen biosynthesis. The emergence of intracrinology, associated with disordered expression of key enzymes such as aromatase, in the aetiology of common women’s health disorders such as endometriosis and endometrial cancer has prompted renewed interest in development of drugs targeting these pathways opening up new opportunities for targeted therapies and precision medicine.   

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Exposure to Bisphenol B Disrupts Steroid Hormone Homeostasis and Gene Expression in the Hypothalamic–Pituitary–Gonadal Axis of Zebrafish

Water Air & Soil Pollution ◽

10.1007/s11270-017-3282-z ◽

2017 ◽

Vol 228 (3) ◽

Cited By ~ 6

Author(s):

Qian Yang ◽

Xianhai Yang ◽

Jining Liu ◽

Wenjuan Ren ◽

Yingwen Chen ◽

...

Keyword(s):

Gene Expression ◽

Steroid Hormone ◽

Hormone Homeostasis

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Congenital generalized lipodystrophy with abnormal growth hormone homeostasis

Archives of Dermatology ◽

10.1001/archderm.104.5.551 ◽

1971 ◽

Vol 104 (5) ◽

pp. 551-559 ◽

Cited By ~ 3

Author(s):

H. Gordon

Keyword(s):

Growth Hormone ◽

Congenital Generalized Lipodystrophy ◽

Abnormal Growth ◽

Hormone Homeostasis

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Real-time imaging of steroid hormone receptor and steroid receptor coactivator-1 in living cells with color variants of green fluorescent protein

Neuroscience Research ◽

10.1016/s0168-0102(00)81227-4 ◽

2000 ◽

Vol 38 ◽

pp. S63

Author(s):

M Nishi

Keyword(s):

Green Fluorescent Protein ◽

Real Time ◽

Hormone Receptor ◽

Fluorescent Protein ◽

Steroid Hormone ◽

Living Cells ◽

Steroid Hormone Receptor ◽

Steroid Receptor Coactivator ◽

Green Fluorescent ◽

Color Variants

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STEROID HORMONE METABOLISM IN RESPONSIVE TISSUES IN VITRO

Acta Endocrinologica ◽

10.1530/acta.0.068s279 ◽

1971 ◽

Vol 68 (1_Suppl) ◽

pp. S279-S294 ◽

Cited By ~ 12

Author(s):

Paul Robel

Keyword(s):

Steroid Hormone ◽

Physiological Activity ◽

Physiological State ◽

Target Cells ◽

Target Tissue ◽

Hormone Metabolism ◽

Metabolizing Enzymes ◽

Relationship Of

ABSTRACT Of the information available on steroid hormone metabolism in responsive tissues, only that relating hormone metabolism to physiological activity is reviewed, i. e. metabolite activity in isolated in vitro systems, binding of metabolites to target tissue receptors, specific steroid hormone metabolizing enzymes and relationship of hormone metabolism to target organ physiological state. Further, evidence is presented in the androgen field, demonstrating 5α-reduced metabolites, formed inside the target cells, as active compounds. This has led to a consideration of testosterone as a »prehormone«. The possibility that similar events take place in tissues responding to progesterone is discussed. Finally, the role of hormone metabolism in the regulation of hormone availability and/or renewal in target cells is discussed. In this context, reference is made to the potential role of plasma binding proteins and cytosol receptors.

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