Prenatal exposure to organochlorine pesticides is associated with increased risk for neural tube defects

2021 ◽  
Vol 770 ◽  
pp. 145284
Author(s):  
Shengju Yin ◽  
Ying Sun ◽  
Jinhui Yu ◽  
Zaiming Su ◽  
Mingkun Tong ◽  
...  
Keyword(s):  
Organochlorine Pesticides ◽  
Prenatal Exposure ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Increased Risk

scholarly journals Prenatal Exposure to Silver is Associated with an Elevated Risk for Neural Tube Defects: A Case Control Study

2021 ◽  
Author(s):  
Xin Pi ◽  
Chengrong Wang ◽  
Di Wang ◽  
Shengju Yin ◽  
Lei Jin ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Prenatal Exposure ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Elevated Risk ◽  
Dietary Intakes ◽  
Risk Area ◽  
Metal Concentrations ◽  
High Risk Area ◽  
Increased Risk

Abstract Background: Exposure to copper, silver, and titanium has been reported to be associated with a variety of adverse effects on humans. However, few studies have focused on the fetus, which is vulnerable to environmental insults. We investigated the associations between prenatal exposure to the three metals and risk for fetal neural tube defects (NTDs).Methods: Placental samples from 408 women with pregnancies affected by NTDs and 593 women with normal pregnancies were collected from 2003 to 2016 in an NTD high-risk area in northern China. Placental metal concentrations were quantified and used as prenatal exposure markers. Multilevel mixed-effects logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between metal concentrations and risk for NTDs. Single and joint effects of the metals on NTDs were evaluated with Bayesian kernel machine regression (BKMR), which can account for correlation, nonlinearity, and interaction between metals.Results: NTDs had higher concentrations of copper (4.16 μg/g) and silver (0.96 ng/g) than controls (copper: 3.91 μg/g; silver: 0.96 ng/g). Silver was associated with an increased risk for NTDs in a dose-response fashion in single-metal logistic regression, with adjusted ORs (95% CIs) of 1.78 (1.04–3.06) and 1.92 (1.11–3.32) in the second and third tertiles, respectively, compared to the lowest tertile. BKMR revealed toxic effects of silver on NTDs when the concentrations of copper and titanium were fixed at their 25th, 50th, and 75th percentiles, and the association appeared to be linear. No interaction of silver with any of the other two metals was observed. Besides, silver concentration was positively correlated with maternal certain dietary intakes, such as meat or fish, during the periconceptional period.Conclusions: High silver concentrations in placental tissue are associated with an elevated risk for NTDs in offspring. Maternal diet may be a source of silver exposure.

scholarly journals Isolated fetal neural tube defects associate with increased risk of placental pathology: Evidence from the Collaborative Perinatal Project

Placenta ◽  
2021 ◽  
Vol 114 ◽  
pp. 56-67
Author(s):  
Marina White ◽  
David Grynspan ◽  
Tim Van Mieghem ◽  
Kristin L. Connor
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Placental Pathology ◽  
Increased Risk

Fetal Repair of Open Neural Tube Defects: Ethical, Legal, and Social Issues

2019 ◽  
Vol 28 (3) ◽  
pp. 476-487 ◽  
Author(s):  
JULIA A.E. RADIC ◽  
JUDY ILLES ◽  
PATRICK J. MCDONALD
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Ethical Issues ◽  
Social Issues ◽  
Controlled Trial ◽  
Fetal Surgery ◽  
Close Monitoring ◽  
Neurologic Outcomes ◽  
Increased Risk ◽  
Fetal Repair

Abstract:Open neural tube defects or myelomeningoceles are a common congenital condition caused by failure of closure of the neural tube early in gestation, leading to a number of neurologic sequelae including paralysis, hindbrain herniation, hydrocephalus and neurogenic bowel and bladder dysfunction. Traditionally, the condition was treated by closure of the defect postnatally but a recently completed randomized controlled trial of prenatal versus postnatal closure demonstrated improved neurologic outcomes in the prenatal closure group. Fetal surgery, or more precisely maternal-fetal surgery, raises a number of ethical issues that we address including who the patient is, informed consent, surgical innovation and equipoise as well maternal assumption of risk. As the procedure becomes more widely adopted into practice, we suggest close monitoring of new fetal surgery centers, in order to ensure that the positive results of the trial are maintained without increased risk to both the mother and fetus.

scholarly journals Transcobalamin II receptor polymorphisms are associated with increased risk for neural tube defects

2010 ◽  
Vol 47 (10) ◽  
pp. 677-685 ◽  
Author(s):  
F. Pangilinan ◽  
A. Mitchell ◽  
J. VanderMeer ◽  
A. M. Molloy ◽  
J. Troendle ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Increased Risk ◽  
Transcobalamin Ii

scholarly journals Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China

2009 ◽  
Vol 12 (5) ◽  
pp. 680-686 ◽  
Author(s):  
Ting Zhang ◽  
Ruolei Xin ◽  
Xue Gu ◽  
Fang Wang ◽  
Lijun Pei ◽  
...  
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Vitamin B ◽  
Risk Area ◽  
High Risk Area ◽  
Increased Risk ◽  
Total Homocysteine

AbstractObjectiveTo examine the association between the risk of neural tube defects (NTD) and maternal serum vitamin B12, folate and homocysteine in a high-risk area of China.DesignA case–control study was carried out in Luliang mountain area of Shanxi Province.Subjects/settingA total of eighty-four NTD pregnancies and 110 matched controls were included in the study; their serum vitamin B12 and folate concentrations were measured by chemiluminescent immunoenzyme assay and total homocysteine concentrations by fluorescent polarisation immunoassay.ResultsSerum vitamin B12 and folate concentrations were lower in NTD-affected pregnant women than in controls (P < 0·01). Serum total homocysteine was higher in the NTD group than in controls at less than 21 weeks of gestation (P < 0·01). Adjusted odds ratios revealed that women with lower vitamin B12 (adjusted OR=4·96; 95 % CI 1·94, 12·67) and folate (adjusted OR=3·23; 95 % CI 1·33, 7·85) concentrations had a higher risk of NTD compared to controls. Based on dietary analysis, less consumption of meat, egg or milk, fresh vegetables and fruit intake would increase the risk of NTD.ConclusionsLower serum concentrations of folate and vitamin B12 are related to the increased risk of NTD in high-risk populations. Both folate and vitamin B12 intake insufficiency could contribute to the increased risk of NTD. A dietary supplement, combining folate and vitamin B12, might be an effective measure to decrease the NTD incidence in these areas.

Prenatal exposure to barium and the occurrence of neural tube defects in offspring

2021 ◽  
Vol 764 ◽  
pp. 144245
Author(s):  
Chengrong Wang ◽  
Xin Pi ◽  
Yongyan Chen ◽  
Di Wang ◽  
Shengju Yin ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Neural Tube ◽  
Neural Tube Defects
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