scholarly journals Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China

2009 ◽  
Vol 12 (5) ◽  
pp. 680-686 ◽  
Author(s):  
Ting Zhang ◽  
Ruolei Xin ◽  
Xue Gu ◽  
Fang Wang ◽  
Lijun Pei ◽  
...  
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Vitamin B ◽  
Risk Area ◽  
High Risk Area ◽  
Increased Risk ◽  
Total Homocysteine

AbstractObjectiveTo examine the association between the risk of neural tube defects (NTD) and maternal serum vitamin B12, folate and homocysteine in a high-risk area of China.DesignA case–control study was carried out in Luliang mountain area of Shanxi Province.Subjects/settingA total of eighty-four NTD pregnancies and 110 matched controls were included in the study; their serum vitamin B12 and folate concentrations were measured by chemiluminescent immunoenzyme assay and total homocysteine concentrations by fluorescent polarisation immunoassay.ResultsSerum vitamin B12 and folate concentrations were lower in NTD-affected pregnant women than in controls (P < 0·01). Serum total homocysteine was higher in the NTD group than in controls at less than 21 weeks of gestation (P < 0·01). Adjusted odds ratios revealed that women with lower vitamin B12 (adjusted OR=4·96; 95 % CI 1·94, 12·67) and folate (adjusted OR=3·23; 95 % CI 1·33, 7·85) concentrations had a higher risk of NTD compared to controls. Based on dietary analysis, less consumption of meat, egg or milk, fresh vegetables and fruit intake would increase the risk of NTD.ConclusionsLower serum concentrations of folate and vitamin B12 are related to the increased risk of NTD in high-risk populations. Both folate and vitamin B12 intake insufficiency could contribute to the increased risk of NTD. A dietary supplement, combining folate and vitamin B12, might be an effective measure to decrease the NTD incidence in these areas.

scholarly journals Screening for congenital neural tube defects in a high-risk area: an epidemiological perspective.

1988 ◽  
Vol 42 (3) ◽  
pp. 271-273 ◽  
Author(s):  
D H Stone ◽  
M J Smalls ◽  
K Rosenberg ◽  
J Womersley
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Risk Area ◽  
High Risk Area

scholarly journals Polymorphism rs1052536 in Base Excision Repair Gene Is a Risk Factor in a High-Risk Area of Neural Tube Defects in China

2018 ◽  
Vol 24 ◽  
pp. 5015-5026 ◽  
Author(s):  
Guannan Li ◽  
Xin Wang ◽  
Xiuwei Wang ◽  
Zhen Guan ◽  
Jin Guo ◽  
...  
Keyword(s):  
Risk Factor ◽  
High Risk ◽  
Base Excision Repair ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Excision Repair ◽  
Risk Area ◽  
Repair Gene ◽  
High Risk Area ◽  
Base Excision

Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area

Gene ◽  
2012 ◽  
Vol 505 (2) ◽  
pp. 340-344 ◽  
Author(s):  
Huizhi Zhao ◽  
Fang Wang ◽  
Jianhua Wang ◽  
Hua Xie ◽  
Jin Guo ◽  
...  
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Risk Area ◽  
High Risk Area

scholarly journals Prenatal Exposure to Silver is Associated with an Elevated Risk for Neural Tube Defects: A Case Control Study

2021 ◽  
Author(s):  
Xin Pi ◽  
Chengrong Wang ◽  
Di Wang ◽  
Shengju Yin ◽  
Lei Jin ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Prenatal Exposure ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Elevated Risk ◽  
Dietary Intakes ◽  
Risk Area ◽  
Metal Concentrations ◽  
High Risk Area ◽  
Increased Risk

Abstract Background: Exposure to copper, silver, and titanium has been reported to be associated with a variety of adverse effects on humans. However, few studies have focused on the fetus, which is vulnerable to environmental insults. We investigated the associations between prenatal exposure to the three metals and risk for fetal neural tube defects (NTDs).Methods: Placental samples from 408 women with pregnancies affected by NTDs and 593 women with normal pregnancies were collected from 2003 to 2016 in an NTD high-risk area in northern China. Placental metal concentrations were quantified and used as prenatal exposure markers. Multilevel mixed-effects logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) for the association between metal concentrations and risk for NTDs. Single and joint effects of the metals on NTDs were evaluated with Bayesian kernel machine regression (BKMR), which can account for correlation, nonlinearity, and interaction between metals.Results: NTDs had higher concentrations of copper (4.16 μg/g) and silver (0.96 ng/g) than controls (copper: 3.91 μg/g; silver: 0.96 ng/g). Silver was associated with an increased risk for NTDs in a dose-response fashion in single-metal logistic regression, with adjusted ORs (95% CIs) of 1.78 (1.04–3.06) and 1.92 (1.11–3.32) in the second and third tertiles, respectively, compared to the lowest tertile. BKMR revealed toxic effects of silver on NTDs when the concentrations of copper and titanium were fixed at their 25th, 50th, and 75th percentiles, and the association appeared to be linear. No interaction of silver with any of the other two metals was observed. Besides, silver concentration was positively correlated with maternal certain dietary intakes, such as meat or fish, during the periconceptional period.Conclusions: High silver concentrations in placental tissue are associated with an elevated risk for NTDs in offspring. Maternal diet may be a source of silver exposure.

scholarly journals The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease

2005 ◽  
Vol 42 (6) ◽  
pp. 459-462 ◽  
Author(s):  
Ann Bowron ◽  
Jeff Scott ◽  
David Stansbie
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
High Risk ◽  
Vascular Disease ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Vitamin Status ◽  
Plasma Thcy ◽  
Increased Risk ◽  
Artery Disease

Background: Elevated plasma total homocysteine (tHcy) predisposes to vascular disease and results from interactions between genetic and nutritional factors. MTHFR C677T increases tHcy in association with low folate. CBS 844ins68 lowers tHcy and negates the raising effect of MTHFR C677T in healthy subjects, but it is unclear if this is the case in subjects at high risk of vascular disease. This study examines the effect on plasma tHcy of interactions between these polymorphisms in an at-risk group. Methods: Blood samples were collected from 376 subjects at increased risk of coronary artery disease. Plasma tHcy and vitamin B6 were measured by HPLC and red cell folate and serum vitamin B12 were measured by immuno-luminometric assay. MTHFR C677T and CBS 844ins68 status was established by standard PCR techniques. Results: MTHFR TT predisposed to hyperhomocysteinaemia; this was increased in the presence of low folate ( P<0.05) and vitamin B12 ( P<0.01). An inverse relationship was found between tHcy and folate ( r= -0.42, P<0.0001), vitamin B12 ( r= -0.26, P<0.0005) and vitamin B6 ( r= -0.25, P<0.01). There was no interaction between plasma tHcy, vitamins or MTHFR C677T and CBS 844ins68. Discussion: In this population at high risk of coronary artery disease, plasma tHcy was determined by vitamin status. This was exacerbated by the MTHFR C677T mutation. CBS 844ins68 did not influence tHcy and did not negate the tHcy-raising effect of MTHFR C677T.

Maternal serum vitamin D levels in pregnancies complicated by neural tube defects

2014 ◽  
Vol 29 (2) ◽  
pp. 298-302 ◽  
Author(s):  
Korkut Daglar ◽  
Aytekin Tokmak ◽  
Ayse Kirbas ◽  
Ali Irfan Guzel ◽  
Kudret Erkenekli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels
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