High concentrations of aluminum in maternal serum and placental tissue are associated with increased risk for fetal neural tube defects

Chemosphere ◽  
2021 ◽  
pp. 131387
Author(s):  
Mengyuan Liu ◽  
Di Wang ◽  
Chengrong Wang ◽  
Shengju Yin ◽  
Xin Pi ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Placental Tissue ◽  
Maternal Serum ◽  
Increased Risk ◽  
High Concentrations

scholarly journals Maternal serum vitamin B12, folate and homocysteine and the risk of neural tube defects in the offspring in a high-risk area of China

2009 ◽  
Vol 12 (5) ◽  
pp. 680-686 ◽  
Author(s):  
Ting Zhang ◽  
Ruolei Xin ◽  
Xue Gu ◽  
Fang Wang ◽  
Lijun Pei ◽  
...  
Keyword(s):  
High Risk ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Serum Vitamin ◽  
Maternal Serum ◽  
Vitamin B ◽  
Risk Area ◽  
High Risk Area ◽  
Increased Risk ◽  
Total Homocysteine

AbstractObjectiveTo examine the association between the risk of neural tube defects (NTD) and maternal serum vitamin B12, folate and homocysteine in a high-risk area of China.DesignA case–control study was carried out in Luliang mountain area of Shanxi Province.Subjects/settingA total of eighty-four NTD pregnancies and 110 matched controls were included in the study; their serum vitamin B12 and folate concentrations were measured by chemiluminescent immunoenzyme assay and total homocysteine concentrations by fluorescent polarisation immunoassay.ResultsSerum vitamin B12 and folate concentrations were lower in NTD-affected pregnant women than in controls (P < 0·01). Serum total homocysteine was higher in the NTD group than in controls at less than 21 weeks of gestation (P < 0·01). Adjusted odds ratios revealed that women with lower vitamin B12 (adjusted OR=4·96; 95 % CI 1·94, 12·67) and folate (adjusted OR=3·23; 95 % CI 1·33, 7·85) concentrations had a higher risk of NTD compared to controls. Based on dietary analysis, less consumption of meat, egg or milk, fresh vegetables and fruit intake would increase the risk of NTD.ConclusionsLower serum concentrations of folate and vitamin B12 are related to the increased risk of NTD in high-risk populations. Both folate and vitamin B12 intake insufficiency could contribute to the increased risk of NTD. A dietary supplement, combining folate and vitamin B12, might be an effective measure to decrease the NTD incidence in these areas.

Fetal Repair of Open Neural Tube Defects: Ethical, Legal, and Social Issues

2019 ◽  
Vol 28 (3) ◽  
pp. 476-487 ◽  
Author(s):  
JULIA A.E. RADIC ◽  
JUDY ILLES ◽  
PATRICK J. MCDONALD
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Ethical Issues ◽  
Social Issues ◽  
Controlled Trial ◽  
Fetal Surgery ◽  
Close Monitoring ◽  
Neurologic Outcomes ◽  
Increased Risk ◽  
Fetal Repair

Abstract:Open neural tube defects or myelomeningoceles are a common congenital condition caused by failure of closure of the neural tube early in gestation, leading to a number of neurologic sequelae including paralysis, hindbrain herniation, hydrocephalus and neurogenic bowel and bladder dysfunction. Traditionally, the condition was treated by closure of the defect postnatally but a recently completed randomized controlled trial of prenatal versus postnatal closure demonstrated improved neurologic outcomes in the prenatal closure group. Fetal surgery, or more precisely maternal-fetal surgery, raises a number of ethical issues that we address including who the patient is, informed consent, surgical innovation and equipoise as well maternal assumption of risk. As the procedure becomes more widely adopted into practice, we suggest close monitoring of new fetal surgery centers, in order to ensure that the positive results of the trial are maintained without increased risk to both the mother and fetus.

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