scholarly journals Short exposure to nitenpyram pesticide induces effects on reproduction, development and metabolic gene expression profiles in Drosophila melanogaster (Diptera: Drosophilidae)

2022 ◽  
Vol 804 ◽  
pp. 150254
Author(s):  
Mohamed Ahmed Ibrahim Ahmed ◽  
Christoph Franz Adam Vogel ◽  
Guilherme Malafaia
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Short Exposure ◽  
Metabolic Gene ◽  
Metabolic Gene Expression

scholarly journals 3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells

2015 ◽  
Vol 35 (3) ◽  
Author(s):  
Yu Takahashi ◽  
Yuji Hori ◽  
Tomohisa Yamamoto ◽  
Toshiki Urashima ◽  
Yasunori Ohara ◽  
...  
Keyword(s):  
Gene Expression ◽  
Apolipoprotein B ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hanging Drop ◽  
Albumin Secretion ◽  
3D Cultures ◽  
Metabolic Gene ◽  
Metabolic Gene Expression ◽  
Heparg Cells

Apo (Apolipoprotein)B secretion, as well as albumin secretion, increased in 3D HepG2 and HepaRG spheroids. Liver metabolic gene expression was up-regulated in 3D HepaRG spheroids. These results suggest that hanging drop 3D cultures can improve hepatocellular responses as a functional liver.

Cold tolerance and proline metabolic gene expression in Drosophila melanogaster

2001 ◽  
Vol 47 (4-5) ◽  
pp. 393-400 ◽  
Author(s):  
Stephen R. Misener ◽  
Cheng-Ping Chen ◽  
Virginia K. Walker
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Cold Tolerance ◽  
Metabolic Gene ◽  
Metabolic Gene Expression

scholarly journals Cardiac physiology and metabolic gene expression during late organogenesis among F. heteroclitus embryo families from crosses between pollution-sensitive and -resistant parents

2022 ◽  
Vol 22 (1) ◽  
Author(s):  
Goran Bozinovic ◽  
Zuying Feng ◽  
Damian Shea ◽  
Marjorie F. Oleksiak
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Parental Effects ◽  
Cardiac Physiology ◽  
Heart Rates ◽  
Metabolic Gene ◽  
Metabolic Gene Expression ◽  
Morphological Deformities

Abstract Background The teleost fish Fundulus heteroclitus inhabit estuaries heavily polluted with persistent and bioaccumulative chemicals. While embryos of parents from polluted sites are remarkably resistant to toxic sediment and develop normally, embryos of parents from relatively clean estuaries, when treated with polluted sediment extracts, are developmentally delayed, displaying deformities characteristic of pollution-induced embryotoxicity. To gain insight into parental effects on sensitive and resistant phenotypes during late organogenesis, we established sensitive, resistant, and crossed embryo families using five female and five male parents from relatively clean and predominantly PAH-polluted estuaries each, measured heart rates, and quantified individual embryo expression of 179 metabolic genes. Results Pollution-induced embryotoxicity manifested as morphological deformities, significant developmental delays, and altered cardiac physiology was evident among sensitive embryos resulting from crosses between females and males from relatively clean estuaries. Significantly different heart rates among several geographically unrelated populations of sensitive, resistant, and crossed embryo families during late organogenesis and pre-hatching suggest site-specific adaptive cardiac physiology phenotypes relative to pollution exposure. Metabolic gene expression patterns (32 genes, 17.9%, at p < 0.05; 11 genes, 6.1%, at p < 0.01) among the embryo families indicate maternal pollutant deposition in the eggs and parental effects on gene expression and metabolic alterations. Conclusion Heart rate differences among sensitive, resistant, and crossed embryos is a reliable phenotype for further explorations of adaptive mechanisms. While metabolic gene expression patterns among embryo families are suggestive of parental effects on several differentially expressed genes, a definitive adaptive signature and metabolic cost of resistant phenotypes is unclear and shows unexpected sensitive-resistant crossed embryo expression profiles. Our study highlights physiological and metabolic gene expression differences during a critical embryonic stage among pollution sensitive, resistant, and crossed embryo families, which may contribute to underlying resistance mechanisms observed in natural F. heteroclitus populations living in heavily contaminated estuaries.

1327: Gene Expression Profiles in Benign Prostatic Hyperplasia

2004 ◽  
Vol 171 (4S) ◽  
pp. 349-350
Author(s):  
Gaelle Fromont ◽  
Michel Vidaud ◽  
Alain Latil ◽  
Guy Vallancien ◽  
Pierre Validire ◽  
...  
Keyword(s):  
Gene Expression ◽  
Benign Prostatic Hyperplasia ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Prostatic Hyperplasia

Regulation of myocardial metabolic gene expression in pressure-overload and exercise-induced hypertrophy

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
M Schwarzer ◽  
C Riehle ◽  
G Pytel ◽  
H Bugger ◽  
D Blum ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pressure Overload ◽  
Metabolic Gene ◽  
Metabolic Gene Expression ◽  
Exercise Induced
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