The aetiology of convulsive status epilepticus: A study of 258 cases in Western China

Abstract Background: To investigate the influential factors of complications on prognosis of patients with status epilepticus, modify the Complication Burden Index （CBI）into the Rankin CBI（RCBI）, and analyze its practicability in status epilepticus in western China. Method: A total of 396 patients with status epilepticus were studied from December 2016 to January 2019 in West China Hospital. The clinical data were collected, including demographic characteristics, status epilepticus characteristics. Statistical analysis was performed using SPSS 22.0 and MedCalc ROC，and logistic regression was used to analyze the influencing factors of hospitalization death and poor prognosis (GOS scale is 1-3). Results: Of the 396 patients with status epilepticus included in the study, 43 (10.9%) died in hospital and 114 (28.8%) had poor prognosis. Using ROC curve analysis, when RCBI > 3, the area under the ROC curve of hospitalization death was 0.914 , p < 0.0001; When RCBI > 3, the area under ROC curve for poor prognosis was 0.882, p < 0.0001. There were 327 people with convulsive status epilepticus, including 41 deaths. When RCBI>3, the area under the hospital mortality curve was 0.915 (p<0.0001). A total of 100 patients had a poor prognosis. When RCBI>3, the area under the poor prognosis curve was 0.867 (p<0.0001). Conclusions: The hospital mortality rate of patients with status epilepticus is 10.9%. RCBI >3 points had a certain significance for predicting hospitalization death and poor prognosis of status epilepticus. There were no significant differences in RCBI scales for convulsive status epilepticus and non-convulsive status epilepticus.

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Faculty Opinions recommendation of Treatment gap for convulsive status epilepticus in resource-poor countries.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.733939146.793551336 ◽

2018 ◽

Author(s):

Richard FM Chin

Keyword(s):

Status Epilepticus ◽

Convulsive Status Epilepticus ◽

Treatment Gap ◽

Poor Countries ◽

Resource Poor

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G171(P) Aetiological profile and immediate outcome predictors of paediatric convulsive status epilepticus: an indian perspective

10.1136/archdischild-2019-rcpch.166 ◽

2019 ◽

Author(s):

R Shriyan ◽

KC Aggarwal ◽

R Gupta

Keyword(s):

Status Epilepticus ◽

Convulsive Status Epilepticus ◽

Outcome Predictors ◽

Indian Perspective

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Continuous EEG monitoring in the follow-up of convulsive status epilepticus patients: A proposal and preliminary validation of an EEG-based seizure build-up score (EaSiBUSSEs)

Neurophysiologie Clinique ◽

10.1016/j.neucli.2021.01.006 ◽

2021 ◽

Author(s):

Aurélie Hanin ◽

Sophie Demeret ◽

Vi-Huong Nguyen-Michel ◽

Virginie Lambrecq ◽

Vincent Navarro

Keyword(s):

Status Epilepticus ◽

Convulsive Status Epilepticus ◽

Eeg Monitoring ◽

Preliminary Validation ◽

Continuous Eeg ◽

Continuous Eeg Monitoring

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Emergency management of the paediatric patient with convulsive status epilepticus

Paediatrics & Child Health ◽

10.1093/pch/pxaa127 ◽

2021 ◽

Vol 26 (1) ◽

pp. 50-57

Author(s):

Kyle C McKenzie ◽

Cecil D Hahn ◽

Jeremy N Friedman

Keyword(s):

Clinical Practice ◽

Status Epilepticus ◽

Emergency Management ◽

Treatment Algorithm ◽

Position Statement ◽

Convulsive Status Epilepticus ◽

Pharmacological Management ◽

The Past ◽

New Treatment ◽

New Evidence

Abstract This guideline addresses the emergency management of convulsive status epilepticus (CSE) in children and infants older than 1 month of age. It replaces a previous position statement from 2011, and includes a new treatment algorithm and table of recommended medications based on new evidence and reflecting the evolution of clinical practice over the past several years. This statement emphasizes the importance of timely pharmacological management of CSE, and includes some guidance for diagnostic approach and supportive care.

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Salzburg Criteria, A Useful Tool in Non-Convulsive Status Epilepticus Diagnosis: A Retrospective Study

Clinical EEG and Neuroscience ◽

10.1177/1550059421991710 ◽

2021 ◽

pp. 155005942199171

Author(s):

Adriana Gómez Domínguez ◽

Raidili C. Mateo Montero ◽

Alba Díaz Cid ◽

Antonio J. P. Mazarro ◽

Ignacio R. Bailly-Bailliere ◽

...

Keyword(s):

Retrospective Study ◽

Status Epilepticus ◽

Prospective Studies ◽

Correct Diagnosis ◽

Original Description ◽

Neurological Deficits ◽

Convulsive Status Epilepticus ◽

Poor Outcome

Introduction. Non-convulsive status epilepticus (NCSE) has been traditionally a challenging electroencephalographic (EEG) diagnosis. For this reason, Salzburg consensus criteria (SCC) have been proposed to facilitate correct diagnosis. Methods. We retrospectively reanalyzed 41 cases referred to our department (from 2016 to 2018) under the suspicion of NCSE. In this study, we compared the original description (standard criteria) versus the updated description (SCC) of the same EEG. Results. Originally, 15 patients were diagnosed as NCSE (37%) and 26 patients as no NCSE (63%), using the standard criteria. Then, we analyzed EEGs according to the SCC, which led to the following results: 9 patients fulfilled the criteria for definite NCSE (22%), 20 patients were diagnosed as possible NCSE (49%) and 12 patients were diagnosed as no NCSE (29%). Subsequently, when we analyze the outcome of possible NCSE cases, we note that 50% of these patients presented mild-poor outcome (neurological deficits, deceased). Indeed, we observed worse outcomes in patients previously diagnosed as no NCSE and untreated, specifically post-anoxic cases. Conclusions. Salzburg criteria seem to be a useful tool to support NCSE diagnosis, introducing the category of possible NCSE. In our study, we observed that it contributes to improving the prognosis and management of the patients. However, more prospective studies are needed to demonstrate the accuracy of SCC.

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