Microbes-mediated synthesis strategies of metal nanoparticles and their potential role in cancer therapeutics

2021 ◽  
Author(s):  
Ali Talha Khalil ◽  
Muhammad Ovais ◽  
Javed Iqbal ◽  
Arbab Ali ◽  
Muhammad Ayaz ◽  
...  
Keyword(s):  
Metal Nanoparticles ◽  
Potential Role ◽  
Cancer Therapeutics

scholarly journals Development of Glypican-3 Targeting Immunotoxins for the Treatment of Liver Cancer: An Update

Biomolecules ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 934
Author(s):  
Bryan D. Fleming ◽  
Mitchell Ho
Keyword(s):  
Liver Cancer ◽  
Half Life ◽  
Potential Role ◽  
Cancer Therapeutics ◽  
Bacterial Toxin ◽  
T Cell Epitopes ◽  
Cancer Treatments ◽  
Liver Cancers ◽  
Global Demand ◽  
High Immunogenicity

Hepatocellular carcinoma (HCC) accounts for most liver cancers and represents one of the deadliest cancers in the world. Despite the global demand for liver cancer treatments, there remain few options available. The U.S. Food and Drug Administration (FDA) recently approved Lumoxiti, a CD22-targeting immunotoxin, as a treatment for patients with hairy cell leukemia. This approval helps to demonstrate the potential role that immunotoxins can play in the cancer therapeutics pipeline. However, concerns have been raised about the use of immunotoxins, including their high immunogenicity and short half-life, in particular for treating solid tumors such as liver cancer. This review provides an overview of recent efforts to develop a glypican-3 (GPC3) targeting immunotoxin for treating HCC, including strategies to deimmunize immunotoxins by removing B- or T-cell epitopes on the bacterial toxin and to improve the serum half-life of immunotoxins by incorporating an albumin binding domain.

scholarly journals The role of the bacterial microbiome in the treatment of cancer

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zi-Kun Yu ◽  
Rui-Ling Xie ◽  
Rui You ◽  
You-Ping Liu ◽  
Xu-Yin Chen ◽  
...  
Keyword(s):  
Potential Role ◽  
Human Microbiome ◽  
Cancer Therapeutics ◽  
Future Research ◽  
Host Immune System ◽  
Cancer Therapies ◽  
Cancer Treatments ◽  
Bacterial Microbiota ◽  
Bacterial Microbiome

AbstractThe human microbiome is defined as the microorganisms that reside in or on the human body, such as bacteria, viruses, fungi, and protozoa, and their genomes. The human microbiome participates in the modulation of human metabolism by influencing several intricate pathways. The association between specific bacteria or viruses and the efficacy of cancer treatments and the occurrence of treatment-related toxicity in cancer patients has been reported. However, the understanding of the interaction between the host microbiome and the cancer treatment response is limited, and the microbiome potentially plays a greater role in the treatment of cancer than reported to date. Here, we provide a thorough review of the potential role of the gut and locally resident bacterial microbiota in modulating responses to different cancer therapeutics to demonstrate the association between the gut or locally resident bacterial microbiota and cancer therapy. Probable mechanisms, such as metabolism, the immune response and the translocation of microbiome constituents, are discussed to promote future research into the association between the microbiome and other types of cancer. We conclude that the interaction between the host immune system and the microbiome may be the basis of the role of the microbiome in cancer therapies. Future research on the association between host immunity and the microbiome may improve the efficacy of several cancer treatments and provide insights into the cause of treatment-related side effects.

Ginseng on Cancer: Potential Role in Modulating Inflammation-Mediated Angiogenesis

2017 ◽  
Vol 45 (01) ◽  
pp. 13-22 ◽  
Author(s):  
Daisy Dai ◽  
Chun-Feng Zhang ◽  
Stephanie Williams ◽  
Chun-Su Yuan ◽  
Chong-Zhi Wang
Keyword(s):  
Tumor Growth ◽  
Potential Role ◽  
Inflammatory Diseases ◽  
Cancer Therapeutics ◽  
Protein Signaling ◽  
Important Target ◽  
Wide Range ◽  
Inhibition Of Angiogenesis ◽  
Pathogen Entry

Angiogenesis is a regulated process integral to many physiological and pathological situations, including carcinogenesis and tumor growth. The majority of the angiogenic processes are related to inflammation. The interplay is not only important in the case of pathogen entry but also influential in chronic inflammatory diseases, tumor growth and tissue regeneration. Modulating the interaction between inflammation and angiogenesis could be an important target for cancer treatment and wound healing alike. Ginseng has a wide range of pharmacological effects, including anti-inflammatory and angiogenesis-modulating activities. This paper presents the recent research progresses on the inhibition of angiogenesis by ginseng and its active constituents, with a particular focus on processes mediated by inflammation. The modulatory role of ginseng compounds in inflammation-mediated angiogenesis involving hypoxia and microRNAs are also discussed. With the potential to modulate the angiogenesis at the transcriptional, translational and protein signaling level via various different mechanisms, ginseng could prove to be effective in cancer therapeutics.

scholarly journals The Potential Role of Aerobic Exercise to Modulate Cardiotoxicity of Molecularly Targeted Cancer Therapeutics

2013 ◽  
Vol 18 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Jessica M. Scott ◽  
Susan Lakoski ◽  
John R. Mackey ◽  
Pamela S. Douglas ◽  
Mark J. Haykowsky ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Potential Role ◽  
Cancer Therapeutics

scholarly journals Celastrol-mediated autophagy regulation in cancer

2020 ◽  
Vol 63 (1) ◽  
Author(s):  
Muhammad Haroon ◽  
Sun Chul Kang
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Potential Role ◽  
Cancer Therapeutics ◽  
Research Area ◽  
Quinone Methide ◽  
Tripterygium Wilfordii ◽  
Anti Cancer ◽  
Significant Research ◽  
Cellular Pathways

AbstractIn the last few decades, studies on autophagy regulation and its potential role in cancer therapeutics have expanded to include detailed mechanisms. Since apoptosis exhibits drug resistance in some cancers, efforts have focused on searching for compounds with autophagy modulating properties. Numerous natural compounds have been used in cancer treatment and are considered a significant research area due to their remarkable anti-cancer properties. Celastrol, a quinone methide triterpene, derived from Tripterygium wilfordii, has recently drawn much attention because of its anticancer potential. It enhances tumor suppression and induces autophagy in cancer cells by regulating signaling pathways such as Beclin-1, Akt/mTOR, ROS, NF-κB, MAPK, HSP90, and the proteasome. In the current study, we address the anticancer potential of celastrol, its effect on various cellular pathways, and describe how it functions as an autophagy modulator in cancer therapeutics and helps diminish multidrug resistance in cancer cells.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

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