Hypnotic medication use among inpatients with schizophrenia and major depressive disorder: results of a nationwide study

2021 ◽  
Author(s):  
Ryuji Furihata ◽  
Rei Otsuki ◽  
Naomi Hasegawa ◽  
Takashi Tsuboi ◽  
Shusuke Numata ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Medication Use ◽  
Major Depressive ◽  
Nationwide Study ◽  
Hypnotic Medication

scholarly journals Antidepressant Use Partially Mediates the Association Between Depression and Risk of Falls and Fall Injuries Among Older Adults

2020 ◽  
Author(s):  
Matthew C Lohman ◽  
Amanda J Fairchild ◽  
Anwar T Merchant
Keyword(s):  
Older Adults ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Fall Risk ◽  
Medication Use ◽  
Community Dwelling ◽  
Major Depressive ◽  
Fall Injuries ◽  
Risk Of Falls ◽  
Antidepressant Use

Abstract Background The association between depression and fall risk in older adults is recognized, yet the mechanisms underlying this association are unclear. This study estimated the mediating role of antidepressant use in the association between depression and falls and fall injuries. Methods Longitudinal data from the Health and Retirement Study (2004–2006) were linked with medication data from the Prescription Drug Study (2005). The sample included community-dwelling adults aged ≥65 with data on depression and medication use (n = 3565). Depression was measured using 2 independent survey tools: Composite International Diagnostic Interview for depression short form and an 8-item version of the Center for Epidemiological Studies-Depression scale. We used causal mediation analysis to estimate and compare the direct and indirect (mediated by antidepressant use) effects of depression on falls and fall injuries. Results Individuals with major depressive disorder were significantly more likely to experience a fall (OR: 1.92; 95% CI: 1.41, 2.62) and a fall injury (OR: 1.67; 95% CI: 1.09, 2.55) over 2 years. Indirect effect estimates showed that antidepressant medication use accounted for approximately 19% and 18% of the association between major depressive disorder and falls and fall injuries, respectively. Results were similar when using an alternative depression measure and when considering only selective serotonin reuptake inhibitor antidepressants. Conclusions Antidepressant use explains a significant proportion, but not a majority, of the association between depression and greater fall risk. Treatment benefits of antidepressants should be considered with, and may outweigh, concerns about increased risk of falls associated with antidepressant use.

scholarly journals Associations of major depressive disorder with chronic physical conditions, obesity and medication use: Results from the PISMA-ep study

2019 ◽  
Vol 60 ◽  
pp. 20-27
Author(s):  
Margarita Rivera ◽  
Alejandro Porras-Segovia ◽  
Paula Rovira ◽  
Esther Molina ◽  
Blanca Gutiérrez ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Health Status ◽  
Depressive Disorder ◽  
Physical Health ◽  
General Health ◽  
Medication Use ◽  
General Health Status ◽  
Major Depressive ◽  
Physical Conditions ◽  
Chronic Physical Conditions

AbstractBackground:Life expectancy of people with depression is on average 15 years less than that of the general population. This excess of mortality is largely attributed to a deteriorated physical health. Evidence about the association between major depressive disorder (MDD) and physical health is still lacking in some areas. The aim of this study was to explore the association between MDD and physical health-related variables in southern Spain.Methods:The PISMA-ep is a cross-sectional study based on community-dwelling adult population. Our main outcome was current prevalence of MDD. Independent variables explored were: lifetime prevalence of twenty-one chronic physical conditions (CPCs), anthropometric measures (height, weight, body max index, and hip and waist circumferences), general health status, and medication use.Results:MDD was significantly associated with any CPC (OR = 2.60; 95% CI: 2.01–3.35; p < 0.001). Increases in BMI were associated with MDD in women (OR=1.08; 95% CI: 1.05–1.11; p < 0.001), but not in men (OR=0.99; 95% CI: 0.95–1.05; p = 0.916). Variables associated with MDD in the multivariate model were: female gender, obesity, general health status, cancer, peptic ulcer, tinnitus and vertigo. 21.4% of participants with MDD received antidepressant treatment.Conclusions:MDD is associated with CPCs, obesity, and increased use of medication. The high rates of comorbidity between MDD and CPCs call for a more holistic management of patients in the clinical practice. The low rate of antidepressant use may be indicating underdiagnosis. Anthropometric variables were differently associated with MDD depending on gender, suggesting a strong influence of psychosocial factors.

scholarly journals Bodily Maps of Emotion in Major Depressive Disorder

2020 ◽  
Author(s):  
Naomi Lyons ◽  
Alexa Strasser ◽  
Bernard Beitz ◽  
Tobias Teismann ◽  
Thomas Ostermann ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Medication Use ◽  
Antidepressant Medication ◽  
The Body ◽  
Healthy Controls ◽  
Major Depressive ◽  
Activation Patterns ◽  
Body Sensation ◽  
Bodily Sensations

Abstract Background Emotions play a central role in mental disorder and especially in depression. They are sensed in the body, and it has recently been shown in healthy participants that these sensations can be differentiated between emotions. The aim of the current study was to assess bodily sensations for basic emotions induced by emotion eliciting pictures in depression. Methods 30 healthy controls (HC), 30 individuals suffering from Major depressive disorder (MDD) without medication use (MDDnm) and 30 individuals with MDD with medication use (MDDm) were shown emotional and neutral pictures and were asked to paint areas in an empty body silhouette where they felt an increase or decrease in activation. Body sensation maps were then calculated and statistical pattern recognition applied. Results Results indicated statistically separable activation patterns for all three groups. MDDnm showed less overall activation than HCs, especially in sadness and fear, while MDDm showed stronger deactivation for all emotions than the other two groups. Conclusions We could show that emotion experience was associated with bodily sensations that are weaker in depression than in healthy controls and that antidepressant medication was correlated with an increased feeling of bodily deactivation. Results give insights into the relevance for clinicians to acknowledge bodily sensations in the treatment of depression.

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