scholarly journals Physical exercise promotes integration of grafted cells and functional recovery in an acute stroke rat model

2022 ◽  
Author(s):  
Rui Wu ◽  
Yiping Guo ◽  
Liying Zhang ◽  
Haiqing Zheng ◽  
Xi Chen ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Acute Stroke ◽  
Functional Recovery ◽  
Rat Model

Insulin-Like Growth Factor I Accelerates Functional Recovery from Achilles Tendon Injury in a Rat Model

1999 ◽  
Vol 27 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Christopher A. Kurtz ◽  
Thomas G. Loebig ◽  
Donald D. Anderson ◽  
Patrick J. DeMeo ◽  
Phil G. Campbell
Keyword(s):  
Growth Factor ◽  
Achilles Tendon ◽  
Functional Recovery ◽  
Rat Model ◽  
Tendon Injury ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I

Xenotransplantation of Porcine Fetal Ventral Mesencephalon in a Rat Model of Parkinson's Disease: Functional Recovery and Graft Morphology

1996 ◽  
Vol 140 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Wendy R. Galpern ◽  
Lindsay H. Burns ◽  
Terrence W. Deacon ◽  
Jonathan Dinsmore ◽  
Ole Isacson
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Recovery ◽  
Rat Model ◽  
Ventral Mesencephalon ◽  
Graft Morphology

Differentiated adipose-derived stem cells promote myelination and enhance functional recovery in a rat model of chronic denervation

2012 ◽  
Vol 90 (7) ◽  
pp. 1392-1402 ◽  
Author(s):  
Koichi Tomita ◽  
Tomas Madura ◽  
Cristina Mantovani ◽  
Giorgio Terenghi
Keyword(s):  
Stem Cells ◽  
Functional Recovery ◽  
Rat Model ◽  
Adipose Derived Stem Cells ◽  
Chronic Denervation

scholarly journals Hypoglossal-facial ‘side’-to-side neurorrhaphy combined with electrical myostimulation for facial palsy in rats

2018 ◽  
Vol 9 (1) ◽  
pp. 167-174
Author(s):  
Binbin Wang ◽  
Shiwei Wang ◽  
Song Liu ◽  
Shaodong Zhang ◽  
Dezhi Li ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Motor Neurons ◽  
Functional Recovery ◽  
Rat Model ◽  
Facial Palsy ◽  
Crush Injury ◽  
Nerve Crush ◽  
Retrograde Labeling ◽  
Electrophysiological Examination ◽  
Nerve Crush Injury

Abstract Introduction This study investigated the effect of combining hypoglossal-facial nerve “side”-to-side neurorrhaphy and electrical myostimulation in a rat model of facial palsy. Methods Rats with facial nerve crush injury were subjected to control condition, monotherapy of either neurorrhaphy or electrical myostimulation, or bitherapy of the two treatments. After 1, 3, and 6 months, rats were performed the facial symmetry evaluation, electrophysiological examination and the retrograde labeling of motor neurons. Results As early as 3 months after injury, face symmetry significantly improved in rats of the bitherapy group. At 3 or 6 months after injury, either the parameters of electrophysiological examination or the number of labeled motor neurons were significantly increased in the bitherapy group than in any other group. Discussion The combination of neurorrhaphy and electrical myostimulation effectively promoted the functional recovery after facial nerve crush injury.

Effects of insulin-like growth factor–I and platelet-rich plasma on sciatic nerve crush injury in a rat model

2011 ◽  
Vol 114 (2) ◽  
pp. 522-528 ◽  
Author(s):  
Erhan Emel ◽  
Selma Sönmez Ergün ◽  
Dilcan Kotan ◽  
Esra Başar Gürsoy ◽  
Yeşim Parman ◽  
...  
Keyword(s):  
Functional Recovery ◽  
Rat Model ◽  
Platelet Rich Plasma ◽  
Sensory Function ◽  
Local Administration ◽  
Control Group ◽  
Factor I ◽  
Igf I ◽  
Group 2 ◽  
Group 1

Object Local administration of insulin-like growth factor–I (IGF-I) has been shown to increase the rate of axon regeneration in crush-injured and freeze-injured rat sciatic nerves. Local administration of platelet-rich plasma (PRP) has been also shown to have a measurable effect on facial nerve regeneration after transection in a rat model. The objective of the study was to compare the effects of locally administered IGF-I and PRP on the parameters of the Sciatic Function Index (SFI), sensory function (SF), axon count, and myelin thickness/axon diameter ratio (G-ratio) in a rat model of crush-injured sciatic nerves. Methods The right sciatic nerve of Wistar albino rats (24 animals) was crushed using a Yasargil-Phynox aneurysm clip for 45 minutes. All animals were randomly divided into 3 groups: Group 1 (control group) was treated with saline, Group 2 was treated with IGF-I, and Group 3 was treated with PRP. Injections were performed using the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery was assessed with improvement in the SFI. Recovery of sensory function was using the pinch test. Histopathological examination was performed 3 months after the injury. Results The SFI showed an improved functional recovery in the IGF-I–treated animals (Group 2) compared with the saline-treated animals (Group 1) 30 days after the injury. In IGF-I–treated rats, sensory function returned to the baseline level significantly faster than in saline-treated and PRP-treated rats as shown in values between SF-2 and SF-7. The G-ratios were found to be significantly higher in both experimental groups than in the control group. Conclusions This study suggests that the application of IGF-I to the crush-injured site may expedite the functional recovery of paralyzed muscle by increasing the rate of axon regeneration.

scholarly journals Adherence to Post-Acute Rehabilitation Guidelines Improves Functional Recovery in Stroke

Stroke ◽  
2001 ◽  
Vol 32 (suppl_1) ◽  
pp. 333-333
Author(s):  
Pamela W Duncan ◽  
Ronnie D Horner ◽  
Dean M Reker ◽  
VA Medical Ctr ◽  
Kansas City ◽  
...  
Keyword(s):  
Quality Of Care ◽  
Acute Stroke ◽  
Functional Recovery ◽  
Stroke Rehabilitation ◽  
Functional Independence ◽  
Case Mix ◽  
Stroke Patients ◽  
Sf 36 ◽  
Acute Rehabilitation

97 Purpose & Methods: To assess if compliance with post-stroke rehabilitation guidelines improves functional recovery. The design of the study was an inception cohort of stroke patients followed prospectively for 6 months. The setting was eleven Department of Veteran Affairs Medical Centers providing care to stroke patients. The subjects included 288 selected patients with stroke admitted between January 1998 - March 1999. Data were abstracted from medical records and telephone interviews. Primary outcome was the Functional Independence Motor Score (FIM). Secondary outcomes included Instrumental Activities of Daily Living (IADL), SF-36 physical functioning, and the Stroke Impact Scale (SIS). Acute and post-acute rehabilitation composite compliance scores (range 0–100) were derived from an algorithm. All outcomes were adjusted for case mix. Results: Average compliance scores in acute and post acute care settings were 68.2% (+ 14) and 69.5% (+ 14.4), respectively. After case-mix adjustment, level of compliance with post-acute rehabilitation guidelines was significantly associated with FIM motor, IADL, and the SIS physical domain scores. SF-36 physical function scores and mortality were not affected by compliance with post-acute rehabilitation guidelines. Level of compliance with rehabilitation guidelines in acute settings was unrelated to any of the outcome measures. Conclusion: Process of care in post-acute stroke rehabilitation affects 6-month functional recovery. Our findings support the use of guidelines as means of assessing quality of care and improving outcomes. These quality indicators are needed to ensure that quality of care is not comprised with new organizational and funding changes involving post-acute stroke care.

Regulation of Autophagy and Ubiquitinated Protein Accumulation by bFGF Promotes Functional Recovery and Neural Protection in a Rat Model of Spinal Cord Injury

2013 ◽  
Vol 48 (3) ◽  
pp. 452-464 ◽  
Author(s):  
Hong-Yu Zhang ◽  
Zhou-Guang Wang ◽  
Fen-Zan Wu ◽  
Xiao-Xia Kong ◽  
Jie Yang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Rat Model ◽  
Protein Accumulation ◽  
Ubiquitinated Protein ◽  
Cord Injury
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