A study on the reaction of 16-dehydropregnenolone acetate with 2-aminobenzimidazole

Steroids ◽  
2017 ◽  
Vol 117 ◽  
pp. 71-76 ◽  
Author(s):  
Agnieszka Wojtkielewicz ◽  
Paulina Uścinowicz ◽  
Leszek Siergiejczyk ◽  
Urszula Kiełczewska ◽  
Artur Ratkiewicz ◽  
...  
RSC Advances ◽  
2015 ◽  
Vol 5 (13) ◽  
pp. 10065-10071 ◽  
Author(s):  
Archana M. Das ◽  
Raju Khan ◽  
Manash P. Hazarika ◽  
Debjani Baruah ◽  
Purnajyoti D. Bhuyan

This paper presents a new method for fabricating biodegradable bio-polymeric nanoparticles via a convenient one-pot strategy at room temperature under stirring conditions for application to communicable diseases.


2015 ◽  
Vol 23 (24) ◽  
pp. 7535-7542 ◽  
Author(s):  
Aylin Viviana Silva-Ortiz ◽  
Eugene Bratoeff ◽  
Teresa Ramírez-Apan ◽  
Yvonne Heuze ◽  
Araceli Sánchez ◽  
...  

Author(s):  
A. A. Akhrem ◽  
I. S. Levina ◽  
Yu. A. Titov ◽  
Yu. N. Bubnov ◽  
B. M. Mikhailov

2020 ◽  
Vol 01 ◽  
Author(s):  
Arun Sethi ◽  
Ranvijay Pratap Singh ◽  
Akriti Bhatia ◽  
Priyanka Yadav

Objective:: In present research article, we synthesized novel pregnane derivatives from 16-dehydropregnenolone acetate (1) which has been obtained by the degradation of naturally occurring plant product-diosgenin. The oxime esters, 3β-acetoxy-pregn-5,16-diene, 20-one O-(2-(6-methoxynaphthalene-2yl) propionyl) oxime (5) and 3β-hydroxy-pregn-5, 16-diene, 20-one O-(2-(4-isobutyl phenyl) propionyl) oxime (6) have been synthesized by reaction of 3β-acetoxy-5,16-pregna-dien-20-oxime (3) with NSAIDs Ibuprofen and naproxen respectively. Methods:: The epoxide derivative 3β-hydroxy-16α, 17α-epoxypregn-5-ene-20-one (4) was opened by BF3.Et2O and yielding product 3,16-di-hydroxy pregn-5-ene-20-one (7) and 3,16,17-tri-hydroxy pregn-5-ene-20-one (8), both the synthesized compounds undergoes esterification with Ibuprofen afforded 3,16-di-(2-(4-isobutyl phenyl) propionoxy) pregn-5-ene-20-one (9) and 3,16-di-(2-(4-isobutyl phenyl) propionoxy) 17-hydroxy pregn-5-ene-20-one (10) respectively. Results and Conclusion:: A one novel pregnane glycoside 3β-[2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopyranosyl]-Oxy-20β-hy-droxy-16α-methoxy-pregn-5-ene (15) has also been synthesized from 3β, 20β-dihydroxy-16α-methoxy-pregn-5-ene (12). After the synthesis all the compounds have been characterized by modern spectroscopic techniques.


2015 ◽  
Vol 46 (1) ◽  
pp. 79-84 ◽  
Author(s):  
Diganta Baruah ◽  
Ram Nath Das ◽  
Dilip Konwar

2015 ◽  
Vol 13 (34) ◽  
pp. 9127-9139 ◽  
Author(s):  
Susana M. M. Lopes ◽  
Cátia F. O. Correia ◽  
Sandra C. C. Nunes ◽  
Nelson A. M. Pereira ◽  
Ana R. F. Ferreira ◽  
...  

16-Dehydropregnenolone acetate reacted with diazafulvenium methides to afford novel chiral 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused steroids.


Author(s):  
A. V. Kamernitskii ◽  
V. N. Ignatov ◽  
I. S. Levina ◽  
V. S. Bogdanov ◽  
E. G. Cherepanov

Author(s):  
A. V. Kamernitskii ◽  
V. N. Ignatov ◽  
I. S. Levina ◽  
�. P. Serebryakov ◽  
V. S. Bogdanov ◽  
...  

ChemInform ◽  
1990 ◽  
Vol 21 (46) ◽  
Author(s):  
I. V. MICOVIC ◽  
M. D. IVANOVIC ◽  
D. M. PIATAK

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