scholarly journals Application of hepatic cytochrome b/P450 reductase null (HBRN) mice to study the role of cytochrome b in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

2019 ◽  
Vol 366 ◽  
pp. 64-74 ◽  
Author(s):  
Lindsay Reed ◽  
Radek Indra ◽  
Iveta Mrizova ◽  
Michaela Moserova ◽  
Heinz H. Schmeiser ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome B ◽  
Anticancer Drug ◽  
P450 Reductase ◽  
Hepatic Cytochrome

scholarly journals Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice

2018 ◽  
Vol 92 (4) ◽  
pp. 1625-1638 ◽  
Author(s):  
Lindsay Reed ◽  
Iveta Mrizova ◽  
Frantisek Barta ◽  
Radek Indra ◽  
Michaela Moserova ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome B ◽  
Adduct Formation ◽  
Dna Adduct ◽  
P450 Reductase ◽  
Hepatic Cytochrome

scholarly journals Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

2005 ◽  
Vol 65 (10) ◽  
pp. 4211-4217 ◽  
Author(s):  
Georgia J. Pass ◽  
Dianne Carrie ◽  
Michael Boylan ◽  
Sally Lorimore ◽  
Eric Wright ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450s ◽  
Null Mouse ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Hepatic Cytochrome

scholarly journals Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

2017 ◽  
Vol 6 (1) ◽  
pp. 81-88 ◽  
Author(s):  
James A. Akingbasote ◽  
Alison J. Foster ◽  
Huw B. Jones ◽  
Rhiannon David ◽  
Nigel J. Gooderham ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Toxicity ◽  
Cytochrome P450 Reductase ◽  
Hepatic Drug ◽  
P450 Reductase ◽  
Liver Histopathology ◽  
Drug Biotransformation ◽  
Fenclozic Acid ◽  
Hepatic Cytochrome

HRN™ mice are valuable for P450-related hepatic drug biotransformation assessment, but not drug toxicity due to underlying liver histopathology.

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH:Cytochrome P450 reductase null mouse

2008 ◽  
Vol 226 (3) ◽  
pp. 318-327 ◽  
Author(s):  
Marie Stiborová ◽  
Volker M. Arlt ◽  
Colin J. Henderson ◽  
C. Roland Wolf ◽  
Věra Kotrbová ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Cytochromes P450 ◽  
Null Mouse ◽  
P450 Reductase ◽  
Nadph:Cytochrome P450 Reductase
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