scholarly journals Role of Hepatic Cytochrome P450s in the Pharmacokinetics and Toxicity of Cyclophosphamide: Studies with the Hepatic Cytochrome P450 Reductase Null Mouse

2005 ◽  
Vol 65 (10) ◽  
pp. 4211-4217 ◽  
Author(s):  
Georgia J. Pass ◽  
Dianne Carrie ◽  
Michael Boylan ◽  
Sally Lorimore ◽  
Eric Wright ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450s ◽  
Null Mouse ◽  
Cytochrome P450 Reductase ◽  
P450 Reductase ◽  
Hepatic Cytochrome

scholarly journals Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid

2017 ◽  
Vol 6 (1) ◽  
pp. 81-88 ◽  
Author(s):  
James A. Akingbasote ◽  
Alison J. Foster ◽  
Huw B. Jones ◽  
Rhiannon David ◽  
Nigel J. Gooderham ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Toxicity ◽  
Cytochrome P450 Reductase ◽  
Hepatic Drug ◽  
P450 Reductase ◽  
Liver Histopathology ◽  
Drug Biotransformation ◽  
Fenclozic Acid ◽  
Hepatic Cytochrome

HRN™ mice are valuable for P450-related hepatic drug biotransformation assessment, but not drug toxicity due to underlying liver histopathology.

Determination of the Role of Target Tissue Metabolism in Lung Carcinogenesis Using Conditional Cytochrome P450 Reductase-Null Mice

2007 ◽  
Vol 67 (16) ◽  
pp. 7825-7832 ◽  
Author(s):  
Yan Weng ◽  
Cheng Fang ◽  
Robert J. Turesky ◽  
Melissa Behr ◽  
Laurence S. Kaminsky ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Target Tissue ◽  
Cytochrome P450 Reductase ◽  
Lung Carcinogenesis ◽  
Tissue Metabolism ◽  
P450 Reductase
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