Neonatal metformin short exposure inhibits male reproductive dysfunction caused by a high-fat diet in adult rats

2021 ◽  
pp. 115712
Author(s):  
Henrique Rodrigues Vieira ◽  
Gessica Dutra Gonçalves ◽  
Vander Silva Alves ◽  
Milene Aparecida Bobato de Melo ◽  
Stephanie Carvalho Borges ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Short Exposure ◽  
High Fat ◽  
Adult Rats ◽  
Reproductive Dysfunction

Programming by Methyl Donor Deficiency during Pregnancy and Lactation Produces Cardiomyopathy in Adult Rats Subjected to High Fat Diet

2021 ◽  
pp. 2100065
Author(s):  
Zhen Li ◽  
Viola J. Kosgei ◽  
Anais Bison ◽  
Jean‐Marc Alberto ◽  
Remi Umoret ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Adult Rats ◽  
Methyl Donor ◽  
Pregnancy And Lactation

scholarly journals Perinatal Exposure to Bisphenol A at Reference Dose Predisposes Offspring to Metabolic Syndrome in Adult Rats on a High-Fat Diet

Endocrinology ◽  
2011 ◽  
Vol 152 (8) ◽  
pp. 3049-3061 ◽  
Author(s):  
Jie Wei ◽  
Yi Lin ◽  
Yuanyuan Li ◽  
Chenjiang Ying ◽  
Jun Chen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Bisphenol A ◽  
High Fat Diet ◽  
Perinatal Exposure ◽  
High Fat ◽  
Adult Rats ◽  
Reference Dose

scholarly journals Adipsin mRNA amounts are not decreased in the genetically obese Zucker rat

1989 ◽  
Vol 257 (3) ◽  
pp. 917-919 ◽  
Author(s):  
I Dugail ◽  
X Le Liepvre ◽  
A Quignard-Boulangé ◽  
J Pairault ◽  
M Lavau
Keyword(s):  
Gene Expression ◽  
High Fat Diet ◽  
Zucker Rats ◽  
Zucker Rat ◽  
Obese Mice ◽  
High Fat ◽  
Adult Rats ◽  
Obese Zucker Rat ◽  
Obese Rats ◽  
Obese Zucker Rats

Adipsin gene expression as assessed by mRNA amounts was examined in adipose tissue of genetically obese rats at the onset (16 days of age) or at later stages (30 and 60 days of age) of obesity. Amounts of mRNA were equivalent in obese and lean rats at 16 days of age. In adult rats, we observed a 2-fold decrease in adipsin mRNA in the obese rats compared with control lean rats, which was abolished by weaning the animals on a high-fat diet. Our data show that, in sharp contrast with genetically obese mice, adipsin mRNA is not suppressed in genetically obese Zucker rats.

A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

Lipids ◽  
2011 ◽  
Vol 46 (11) ◽  
pp. 1071-1074 ◽  
Author(s):  
Tchana Weyll Souza Oliveira ◽  
Carol Góis Leandro ◽  
Tereza Cristina Bomfim de Jesus Deiró ◽  
Gabriela dos Santos Perez ◽  
Darlene da França Silva ◽  
...  
Keyword(s):  
Food Intake ◽  
High Fat Diet ◽  
High Fat ◽  
Adult Rats

High-fat diet preference in developing and adult rats

1990 ◽  
Vol 48 (1) ◽  
pp. 79-82 ◽  
Author(s):  
Gary A. Rockwood ◽  
Sam J. Bhathena
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Adult Rats ◽  
Diet Preference

scholarly journals High-Fat Programming of Hyperglycemia, Hyperinsulinemia, Insulin Resistance, Hyperleptinemia, and Altered Islet Architecture in 3-Month-Old Wistar Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Marlon E. Cerf ◽  
Charna S. Chapman ◽  
Johan Louw
Keyword(s):  
Cell Proliferation ◽  
Acinar Cell ◽  
High Fat Diet ◽  
Alpha Cell ◽  
Postnatal Life ◽  
Fetal Life ◽  
High Fat ◽  
Cell Hyperplasia ◽  
Adult Rats ◽  
Ki 67

High-fat programming, by exposure to a high-saturated-fat diet in utero and/or during lactation, compromises beta-cell development and function in neonatal and weanling offspring. Therefore, high-fat programming effects were investigated on metabolism and islet architecture in young adult rats. Three-month-old male and female Wistar rat offspring were studied: HFG (maintained on a high-fat diet throughout fetal life), HFP (high-fat diet maintenance from birth to 3 months), and HFGP (high-fat diet maintenance throughout fetal and postnatal life). Control rats were maintained on a standard laboratory diet. Pancreata were double immunolabeled for insulin and glucagon to assess islet morphology and with Ki-67 to determine islet and acinar cell proliferation. HFP and HFGP males were heavier, hyperleptinemic, and hyperinsulinemic. Hyperglycemia presented in HFP males, HFP females, and HFGP males. HFGP males and HFP females were insulin resistant. HFP males displayed beta- and alpha-cell hyperplasia with alpha-cell hypertrophy evident in HFP females. Acinar cell proliferation rates were increased in HFP males. Postnatal high-fat programming induced the most diabetogenic phenotype with high-fat maintenance throughout fetal and postnatal life resulting in a severely obese phenotype. Fetal and postnatal nutrition shapes offspring health outcomes.

Effects of Hwangryunjihwang-tang on In Vitro Fertilization and Ovulation in Mice Fed a High-fat Diet

2003 ◽  
Vol 31 (02) ◽  
pp. 213-223
Author(s):  
H. G. Choi ◽  
D. H. Kwak ◽  
J. Y. Kim ◽  
Y. J. Choi ◽  
B. S. Kil ◽  
...  
Keyword(s):  
Body Weight ◽  
Embryonic Development ◽  
High Fat Diet ◽  
Normal Diet ◽  
The Body ◽  
High Fat ◽  
Reproductive Dysfunction ◽  
Vitro Fertilization

It has been generally accepted that Hwangryunjihwang-tang (H-tang) is a useful prescription for treating polydipsia and to prevent obesity induced by a high-fat diet. The aim of this study was to clarify whether H-tang improved reproductive dysfunction caused by obesity in mice. Mice were fed a high density protein and lipid diet for 4 weeks, followed by administration of H-tang at 480 mg/kg body weight per day for 4 days. Thereafter, changes of body weight, ovulation rate, in vitro and in vivo fertilization, embryonic development and implantation rate were measured. H-tang markedly reduced the body weight of obese mice fed a high-fat diet, but not mice fed a normal diet. H-tang significantly improved ovulation rates, in vitro and in vivo fertilization rates and embryonic development. These results indicate pharmacological reversal of reproductive dysfunction caused by obesity, perhaps by adjusting internal secretions and metabolic functions.

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