Surface enhanced Raman spectroscopy (SERS) as a method for the toxicological analysis of synthetic cannabinoids

Talanta ◽  
2017 ◽  
Vol 164 ◽  
pp. 396-402 ◽  
Author(s):  
Thaddeus Mostowtt ◽  
Bruce McCord
Keyword(s):  
Raman Spectroscopy ◽  
Synthetic Cannabinoids ◽  
Surface Enhanced Raman Spectroscopy ◽  
Toxicological Analysis ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

An evaluation of monovalent, divalent, and trivalent cations as aggregating agents for surface enhanced Raman spectroscopy (SERS) analysis of synthetic cannabinoids

The Analyst ◽  
2019 ◽  
Vol 144 (21) ◽  
pp. 6404-6414
Author(s):  
Thaddeus Mostowtt ◽  
Jonathan Munoz ◽  
Bruce McCord
Keyword(s):  
Raman Spectroscopy ◽  
Synthetic Cannabinoids ◽  
Detection Limits ◽  
Surface Enhanced Raman Spectroscopy ◽  
Critical Coagulation Concentration ◽  
Surface Enhanced ◽  
Nitrate Salts ◽  
Surface Enhanced Raman ◽  
Trivalent Cations ◽  
Chloride Sulfate

Monovalent, divalent and trivalent chloride, sulfate and nitrate salts were examined to determine the critical coagulation concentration (CCC) for each salt and its corresponding effect on detection limits for SERS analysis of synthetic cannabinoids.

Bacterial detection and differentiation via direct volatile organic compound sensing with surface enhanced Raman spectroscopy

2017 ◽  
Author(s):  
Caitlin S. DeJong ◽  
David I. Wang ◽  
Aleksandr Polyakov ◽  
Anita Rogacs ◽  
Steven J. Simske ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Bacterial Infections ◽  
Direct Detection ◽  
Point Of Care ◽  
Surface Enhanced Raman Spectroscopy ◽  
E Coli ◽  
Recent Emergence ◽  
Surface Enhanced ◽  
Volatile Organic ◽  
Surface Enhanced Raman

Through the direct detection of bacterial volatile organic compounds (VOCs), via surface enhanced Raman spectroscopy (SERS), we report here a reconfigurable assay for the identification and monitoring of bacteria. We demonstrate differentiation between highly clinically relevant organisms: <i>Escherichia coli</i>, <i>Enterobacter cloacae</i>, and <i>Serratia marcescens</i>. This is the first differentiation of bacteria via SERS of bacterial VOC signatures. The assay also detected as few as 10 CFU/ml of <i>E. coli</i> in under 12 hrs, and detected <i>E. coli</i> from whole human blood and human urine in 16 hrs at clinically relevant concentrations of 10<sup>3</sup> CFU/ml and 10<sup>4</sup> CFU/ml, respectively. In addition, the recent emergence of portable Raman spectrometers uniquely allows SERS to bring VOC detection to point-of-care settings for diagnosing bacterial infections.

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