Electrochemical LAMP-based assay for detection of RNA biomarkers in prostate cancer

Talanta ◽  
2021 ◽  
pp. 123064
Author(s):  
Ludmila Moranova ◽  
Michal Stanik ◽  
Roman Hrstka ◽  
Susana Campuzano ◽  
Martin Bartosik
Keyword(s):  
Prostate Cancer ◽  
Rna Biomarkers

scholarly journals Detecting long non-coding RNA biomarkers in prostate cancer liquid biopsies: Hype or hope?

2018 ◽  
Vol 3 (2) ◽  
pp. 64-74 ◽  
Author(s):  
Hetty Helsmoortel ◽  
Celine Everaert ◽  
Nicolaas Lumen ◽  
Piet Ost ◽  
Jo Vandesompele
Keyword(s):  
Prostate Cancer ◽  
Liquid Biopsies ◽  
Non Coding Rna ◽  
Long Non Coding Rna ◽  
Rna Biomarkers

scholarly journals Blood platelets contain tumor-derived RNA biomarkers

Blood ◽  
2011 ◽  
Vol 118 (13) ◽  
pp. 3680-3683 ◽  
Author(s):  
R. Jonas A. Nilsson ◽  
Leonora Balaj ◽  
Esther Hulleman ◽  
Sjoerd van Rijn ◽  
D. Michiel Pegtel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Personalized Medicine ◽  
Cancer Patients ◽  
Expression Profiling ◽  
Blood Platelets ◽  
Companion Diagnostics ◽  
Rna Biomarkers

Abstract Diagnostic platforms providing biomarkers that are highly predictive for diagnosing, monitoring, and stratifying cancer patients are key instruments in the development of personalized medicine. We demonstrate that tumor cells transfer (mutant) RNA into blood platelets in vitro and in vivo, and show that blood platelets isolated from glioma and prostate cancer patients contain the cancer-associated RNA biomarkers EGFRvIII and PCA3, respectively. In addition, gene-expression profiling revealed a distinct RNA signature in platelets from glioma patients compared with normal control subjects. Because platelets are easily accessible and isolated, they may form an attractive platform for the companion diagnostics of cancer.

scholarly journals Prostate-based biofluids for the detection of prostate cancer: A comparative study of the diagnostic performance of cell-sourced RNA biomarkers

2016 ◽  
Vol 4 (3) ◽  
pp. 97-102 ◽  
Author(s):  
Matthew J. Roberts ◽  
Renee S. Richards ◽  
Clement W.K. Chow ◽  
Suhail A.R. Doi ◽  
Horst Joachim Schirra ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Comparative Study ◽  
Diagnostic Performance ◽  
Rna Biomarkers

scholarly journals RNA biomarkers to facilitate the identification of aggressive prostate cancer

2015 ◽  
Vol 45 ◽  
pp. 37-46 ◽  
Author(s):  
Kathryn L. Pellegrini ◽  
Martin G. Sanda ◽  
Carlos S. Moreno
Keyword(s):  
Prostate Cancer ◽  
Aggressive Prostate Cancer ◽  
Rna Biomarkers

scholarly journals RNA biomarkers associated with metastatic progression in prostate cancer: a multi-institutional high-throughput analysis of SChLAP1

2014 ◽  
Vol 15 (13) ◽  
pp. 1469-1480 ◽  
Author(s):  
John R Prensner ◽  
Shuang Zhao ◽  
Nicholas Erho ◽  
Matthew Schipper ◽  
Matthew K Iyer ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Throughput ◽  
Metastatic Progression ◽  
High Throughput Analysis ◽  
Throughput Analysis ◽  
Rna Biomarkers

scholarly journals Primary candidate RNA biomarker screening by RNA-seq for prostate cancer diagnostics

2015 ◽  
Vol 61 (6) ◽  
pp. 781-784 ◽  
Author(s):  
A.S. Nikitina ◽  
V.V. Babenko ◽  
K.A. Babalyan ◽  
A.O. Vasiliev ◽  
A.V. Govorov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Minimally Invasive ◽  
Transcriptome Profiling ◽  
Cancer Diagnostics ◽  
Library Preparation ◽  
Rna Seq ◽  
Noninvasive Methods ◽  
Plasma And Urine Samples ◽  
Invasive Diagnostics ◽  
Rna Biomarkers

The RNA-seq approach for prostate cancer candidate RNA biomarkers screening in plasma and urine obtained by minimally invasive or noninvasive methods is proved to be feasible. Significant amount of RNA biomarkers associated with prostate cancer according to the literature were found in plasma and urine samples obtained from patients with benign prostatic hyperplasia (BPH). The number of detected markers was shown to vary in accordance with method of library preparation used for transcriptome profiling. The detection of known RNA biomarkers for prostate cancer in urine and plasma samples shows the feasibility of such method for minimally invasive diagnostics. The fact of presence of the same RNA biomarkers in samples from patients with BPH suggests their possible lack of specificity and confirms the need for further research in this area.

scholarly journals Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of formalin-fixed samples obtained from Russian patients

Oncotarget ◽  
2017 ◽  
Vol 8 (20) ◽  
pp. 32990-33001 ◽  
Author(s):  
Anastasia S. Nikitina ◽  
Elena I. Sharova ◽  
Svetlana A. Danilenko ◽  
Tatiana B. Butusova ◽  
Alexandr O. Vasiliev ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Rna Seq ◽  
Rna Biomarkers ◽  
Formalin Fixed

Primary screening of candidate RNA biomarkers for diagnostics of prostate cancer

2016 ◽  
Vol 10 (2) ◽  
pp. 180-183
Author(s):  
A. S. Nikitina ◽  
V. V. Babenko ◽  
K. A. Babalyan ◽  
A. O. Vasiliev ◽  
A. V. Govorov ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Primary Screening ◽  
Rna Biomarkers
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