Structure and conformation of HIV fusion inhibitor peptide T-1249 in presence of model membranes: A molecular dynamics study

2010 ◽  
Vol 946 (1-3) ◽  
pp. 119-124 ◽  
Author(s):  
A.M.T. Martins do Canto ◽  
A.J. Palace Carvalho ◽  
J.P. Prates Ramalho ◽  
Luís M.S. Loura
Keyword(s):  
Molecular Dynamics ◽  
Model Membranes ◽  
Fusion Inhibitor ◽  
Peptide T ◽  
Inhibitor Peptide

Molecular dynamics simulations of T-20 HIV fusion inhibitor interacting with model membranes

2011 ◽  
Vol 159 (2-3) ◽  
pp. 275-286 ◽  
Author(s):  
A.M.T. Martins do Canto ◽  
A.J. Palace Carvalho ◽  
J.P. Prates Ramalho ◽  
Luís M.S. Loura
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulations ◽  
Model Membranes ◽  
Fusion Inhibitor ◽  
Dynamics Simulations

HIV Fusion Inhibitor Peptide T-1249 Is Able To Insert or Adsorb to Lipidic Bilayers. Putative Correlation with Improved Efficiency

2004 ◽  
Vol 126 (45) ◽  
pp. 14758-14763 ◽  
Author(s):  
A. Salomé Veiga ◽  
Nuno C. Santos ◽  
Luís M. S. Loura ◽  
Aleksandre Fedorov ◽  
Miguel A. R. B. Castanho
Keyword(s):  
Fusion Inhibitor ◽  
Peptide T ◽  
Inhibitor Peptide

Half-life extension of the HIV-fusion inhibitor peptide TRI-1144 using a novel linker technology

2015 ◽  
Vol 93 ◽  
pp. 254-259 ◽  
Author(s):  
Eric L. Schneider ◽  
Gary W. Ashley ◽  
Lieve Dillen ◽  
Bart Stoops ◽  
Nigel E. Austin ◽  
...  
Keyword(s):  
Half Life ◽  
Life Extension ◽  
Fusion Inhibitor ◽  
Inhibitor Peptide

Molecular dynamics of model membranes

1980 ◽  
Vol 6 (S1) ◽  
pp. 106-106 ◽  
Author(s):  
P. Ploeg ◽  
H. J. C. Berendsen
Keyword(s):  
Molecular Dynamics ◽  
Model Membranes

scholarly journals A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV

Viruses ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 448 ◽  
Author(s):  
Changfa Fan ◽  
Xi Wu ◽  
Qiang Liu ◽  
Qianqian Li ◽  
Susu Liu ◽  
...  
Keyword(s):  
Antiviral Agents ◽  
Respiratory Illness ◽  
Clinical Strain ◽  
Fusion Inhibitor ◽  
Dipeptidyl Peptidase 4 ◽  
Susceptibility To Infection ◽  
Inhibitor Peptide ◽  
Novel Model ◽  
Biosafety Level ◽  
Knockin Mouse

Infection by the Middle East respiratory syndrome coronavirus (MERS-CoV) causes respiratory illness and has a high mortality rate (~35%). The requirement for the virus to be manipulated in a biosafety level three (BSL-3) facility has impeded development of urgently-needed antiviral agents. Here, we established anovel mouse model by inserting human dipeptidyl peptidase 4 (hDPP4) into the Rosa26 locus using CRISPR/Cas9, resulting in global expression of the transgene in a genetically stable mouse line. The mice were highly susceptible to infection by MERS-CoV clinical strain hCoV-EMC, which induced severe diffuse pulmonary disease in the animals, and could also be infected by an optimized pseudotyped MERS-CoV. Administration of the neutralizing monoclonal antibodies, H111-1 and m336, as well as a fusion inhibitor peptide, HR2P-M2, protected mice from challenge with authentic and pseudotyped MERS-CoV. These results confirmed that the hDPP4-knockin mouse is a novel model for studies of MERS-CoV pathogenesis and anti-MERS-CoV antiviral agents in BSL-3 and BSL-2facilities, respectively.

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