Clinical, pathologic, and epidemiologic features of nocardioform placentitis in the mare

Among the diverse forms of lung involvement, interstitial lung disease (ILD) and pulmonary arterial hypertension (PAH) are two important conditions in patients with rheumatic diseases that are associated with significant morbidity and mortality. The management of ILD and PAH is challenging because the current treatment often provides only limited patient survival benefits. Such challenges derive from their common pathogenic mechanisms, where not only the inflammatory processes of immune cells but also the fibrotic and proliferative processes of nonimmune cells play critical roles in disease progression, making immunosuppressive therapy less effective. Recently, updated treatment strategies adopting targeted agents have been introduced with promising results in clinical trials for ILD ad PAH. This review discusses the epidemiologic features of ILD and PAH among patients with rheumatic diseases (rheumatoid arthritis, myositis, and systemic sclerosis) and the state-of-the-art treatment options, focusing on targeted agents including biologics, antifibrotic agents, and vasodilatory drugs.

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Epidemiologic Features of Antipsychotic Prescribing to Children and Adolescents in Primary Care in the United Kingdom

PEDIATRICS ◽

10.1542/peds.2007-2008 ◽

2008 ◽

Vol 121 (5) ◽

pp. 1002-1009 ◽

Cited By ~ 132

Author(s):

F. Rani ◽

M. L. Murray ◽

P. J. Byrne ◽

I. C. K. Wong

Keyword(s):

Primary Care ◽

United Kingdom ◽

Children And Adolescents ◽

The United Kingdom ◽

Antipsychotic Prescribing ◽

Epidemiologic Features

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Clinicopathologic Correlation of Epidemiologic and Histopathologic Features of Pediatric Bacterial Lymphadenitis

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2010-0581-oa ◽

2011 ◽

Vol 135 (11) ◽

pp. 1490-1493 ◽

Cited By ~ 12

Author(s):

Flavia G. Nunes Rosado ◽

Charles W. Stratton ◽

Claudio A. Mosse

Keyword(s):

Lymph Node ◽

Bartonella Henselae ◽

Lymph Node Biopsy ◽

Mycobacterium Fortuitum ◽

Tissue Sections ◽

Node Biopsy ◽

Identification Of Bacteria ◽

Histopathologic Findings ◽

Epidemiologic Features ◽

Histopathologic Features

Context.—Infection is a common cause of lymphadenopathy in children and has numerous microbial etiologies. Lymph node biopsy is considered a keystone in arriving at a definite diagnosis. An accurate differential diagnosis from a lymph node biopsy can expedite diagnosis and minimize ancillary testing. Objective.—To assess and compare the histopathologic and epidemiologic features of common and uncommon pediatric bacterial lymphadenitis. Design.—We searched our database for surgical specimens that had a positive identification of bacteria during an 8-year period. The chart was reviewed to assess the pathogen identified and epidemiologic data. The archival tissue sections were reviewed and the histopathologic findings described for each pathogen. Results.—The review of 368 pediatric lymph node biopsies identified 33 cases with a bacterial infection. These comprised 21 cases of Mycobacterium avium complex (60%), 1 of Mycobacterium fortuitum (3%), 7 of Bartonella henselae (20%), 2 of Yersinia enterocolitica (7%), 1 of Francisella tularensis (3%) and 1 of Streptococcus pyogenes (3%). Conclusions.—Each of these infectious lymphadenitides had distinct epidemiologic and histopathologic features that are discussed in this report.

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Blood Transfusion–Associated HIV Infection in Children in Ibadan, Nigeria

Journal of the International Association of Providers of AIDS Care (JIAPAC) ◽

10.1177/2325957413500990 ◽

2013 ◽

Vol 16 (3) ◽

pp. 303-308 ◽

Cited By ~ 3

Author(s):

Biobele J. Brown ◽

Regina E. Oladokun ◽

Babatunde O. Ogunbosi ◽

Kikelomo Osinusi

Keyword(s):

Blood Transfusion ◽

Hiv Infection ◽

Public Hospitals ◽

Pediatric Hiv ◽

College Hospital ◽

Private Hospitals ◽

Safety Practices ◽

The University ◽

Epidemiologic Features ◽

Ibadan Nigeria

Introduction: This study describes the epidemiologic features and clinical course of children with blood transfusion-associated HIV infection (TAHI) in Ibadan, Nigeria. Methodology: All children diagnosed to have TAHI at the University College Hospital, Ibadan, were studied and compared with children who acquired HIV vertically using the pediatric HIV database in the hospital. Results: Transfusion-associated HIV infection accounted for 14 (2.3%) of the 597 children diagnosed to have HIV infection between January 2004 and December 2011. The mean age at diagnosis of TAHI was 10.2 years and that of vertically acquired HIV infection was 3.9 years ( P < .001). In 9 cases, blood transfusion took place in private hospitals and in 5 cases in public hospitals. Median interval between infection and diagnosis of AIDS was 84 months in cases with TAHI and 48 months in vertically acquired cases ( P = .542). Conclusion: Optimal blood safety practices are advocated for prevention of TAHI in Nigeria.

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