scholarly journals Cell type-specific expression and localization of cytochrome P450 isoforms in tridimensional aggregating rat brain cell cultures

2015 ◽  
Vol 30 (1) ◽  
pp. 176-184 ◽  
Author(s):  
S. Vichi ◽  
J. Sandström von Tobel ◽  
S. Gemma ◽  
S. Stanzel ◽  
A. Kopp-Schneider ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rat Brain ◽  
Cell Cultures ◽  
Brain Cell ◽  
Cell Type ◽  
Specific Expression ◽  
Cytochrome P450 Isoforms ◽  
Cell Type Specific Expression ◽  
Cell Type Specific ◽  
Brain Cell Cultures

Delta-9-tetrahydrocannabinol accumulation, metabolism and cell-type-specific adverse effects in aggregating brain cell cultures

2008 ◽  
Vol 228 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Florianne Monnet-Tschudi ◽  
Arno Hazekamp ◽  
Nicolas Perret ◽  
Marie-Gabrielle Zurich ◽  
Patrice Mangin ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Cell Cultures ◽  
Brain Cell ◽  
Cell Type ◽  
Cell Type Specific ◽  
Brain Cell Cultures

scholarly journals Isoform-specific roles for AKT in affective behavior, spatial memory, and extinction related to psychiatric disorders

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Helen Wong ◽  
Josien Levenga ◽  
Lauren LaPlante ◽  
Bailey Keller ◽  
Andrew Cooper-Sansone ◽  
...  
Keyword(s):  
Neuropsychiatric Disorders ◽  
Brain Cell ◽  
Long Term Memory ◽  
Cell Type ◽  
Specific Expression ◽  
Specific Effects ◽  
Cell Type Specific Expression ◽  
Cell Type Specific ◽  
Influence Behavior

AKT is implicated in neurological disorders. AKT has three isoforms, AKT1/AKT2/AKT3, with brain cell type-specific expression that may differentially influence behavior. Therefore, we examined single Akt isoform, conditional brain-specific Akt1, and double Akt1/3 mutant mice in behaviors relevant to neuropsychiatric disorders. Because sex is a determinant of these disorders but poorly understood, sex was an experimental variable in our design. Our studies revealed AKT isoform- and sex-specific effects on anxiety, spatial and contextual memory, and fear extinction. In Akt1 mutant males, viral-mediated AKT1 restoration in the prefrontal cortex rescued extinction phenotypes. We identified a novel role for AKT2 and overlapping roles for AKT1 and AKT3 in long-term memory. Finally, we found that sex-specific behavior effects were not mediated by AKT expression or activation differences between sexes. These results highlight sex as a biological variable and isoform- or cell type-specific AKT signaling as potential targets for improving treatment of neuropsychiatric disorders.

Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma

2006 ◽  
Vol 64 (2) ◽  
pp. 230-243 ◽  
Author(s):  
N. E. Savaskan ◽  
L. Rocha ◽  
M. R. Kotter ◽  
A. Baer ◽  
G. Lubec ◽  
...  
Keyword(s):  
Brain Cell ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
Cell Type Specific ◽  
The Brain

scholarly journals A cell type‐specific expression map of NCoR1 and SMRT transcriptional co‐repressors in the mouse brain

2020 ◽  
Vol 528 (13) ◽  
pp. 2218-2238 ◽  
Author(s):  
Attilio Iemolo ◽  
Patricia Montilla‐Perez ◽  
I‐Chi Lai ◽  
Yinuo Meng ◽  
Syreeta Nolan ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Cell Type ◽  
Specific Expression ◽  
Cell Type Specific Expression ◽  
A Cell ◽  
Cell Type Specific
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