In silico modelling of acute toxicity of 1, 2, 4-triazole antifungal agents towards zebrafish (Danio rerio) embryos: Application of the Small Dataset Modeller tool

2021 ◽  
pp. 105205
Author(s):  
Aniket Nath ◽  
Priyanka De ◽  
Kunal Roy
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
In Silico ◽  
Antifungal Agents ◽  
In Silico Modelling ◽  
Small Dataset ◽  
Danio Rerio Embryos

scholarly journals Acute toxicity and gene responses induced by endosulfan in zebrafish (Danio rerio) embryos

2016 ◽  
Vol 28 (1-4) ◽  
pp. 103-109 ◽  
Author(s):  
Young-Sun Moon ◽  
Hwang-Ju Jeon ◽  
Tae-Hoon Nam ◽  
Sung-Deuk Choi ◽  
Byung-Jun Park ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Danio Rerio Embryos

Fluoxastrobin-induced effects on acute toxicity, development toxicity, oxidative stress, and DNA damage in Danio rerio embryos

2020 ◽  
Vol 715 ◽  
pp. 137069 ◽  
Author(s):  
Cheng Zhang ◽  
Jingwen Zhang ◽  
Lusheng Zhu ◽  
Zhongkun Du ◽  
Jun Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Acute Toxicity ◽  
Danio Rerio ◽  
Danio Rerio Embryos

QSAR models for the acute toxicity of 1,2,4-triazole fungicides to zebrafish (Danio rerio) embryos

2020 ◽  
Vol 265 ◽  
pp. 114837 ◽  
Author(s):  
Kun Qiao ◽  
Wenjie Fu ◽  
Yao Jiang ◽  
Lili Chen ◽  
Shuying Li ◽  
...  
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Triazole Fungicides ◽  
Qsar Models ◽  
Danio Rerio Embryos

scholarly journals Acute toxicity of jalawure (Tacca leontopetaloides (L.) Kuntze) and gadung tikus (Tacca palmata Blume) using zebrafish (Danio rerio) embryos as a model

2021 ◽  
Vol 12 (2) ◽  
pp. 1247-1253
Author(s):  
Agus W ◽  
Suganda A G ◽  
Fidrianny I
Keyword(s):  
Acute Toxicity ◽  
Danio Rerio ◽  
Leaf Extract ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Test Protocol ◽  
Fish Embryo ◽  
Stem Extract ◽  
Danio Rerio Embryos

Tacca is a genus of several species reported to have potential as a new therapeutic agent with toxic properties for several cells. Jalawure and gadung tikus are two species from the Tacca genus that can be found in Indonesia. The aim of this study was to determine the level of acute toxicity of jalawure and gadung tikus by using zebrafish (Danio rerio) embryos as a model. The sample was extracted by maceration using ethanol 96%. The acute toxicity test was carried out by using fish embryo acute toxicity (FET) test protocol No. 236, Organisation for Economic Co-Operation and Development (OECD), 96 hr of static exposure using the negative control group (medium embryo), the test solution group (extract) and the positive control group (3,4-dichloroaniline 4 µg/ml). The result of acute toxicity of extract against zebrafish embryos demonstrated that LC50 of jalawure leaf extract 26.06 ± 0.31 µg/ml, jalawure stem extract 251.52 ± 6.15 µg/ml,  jalawure corm extract 463.24 ± 9.68 µg/ml, gadung tikus leaf extract 15.04 ± 0.15 µg/ml, gadung tikus stem extract 263.73 ± 6.58 µg/ml, and gadung tikus corm extract 17.71 ± 0.12 µg/ml. Embryo coagulation was the endpoint that was most commonly found in almost all extracts. Gadung tikus leaves extract, gadung tikus corm extract and jalawure leaves extract expressed moderate toxicity level.

Neurulation in the posterior region of zebrafish, Danio rerio embryos

2021 ◽  
Author(s):  
Julia Gladysheva ◽  
Evdokia Evnukova ◽  
Ekaterina Kondakova ◽  
Milana Kulakova ◽  
Vladimir Efremov
Keyword(s):  
Danio Rerio ◽  
Posterior Region ◽  
Danio Rerio Embryos
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