Delayed haemolysis after IV artesunate therapy for P. falciparum infection

2021 ◽  
pp. 102230
Author(s):  
Ròisìn O'Connor ◽  
Ciara Conlan ◽  
Conor Grant ◽  
Nora Kinsella ◽  
Miriam Moriarty ◽  
...  
Keyword(s):  
Falciparum Infection ◽  
Delayed Haemolysis

Platelet Hypersensitivity in Acute Malaria (Plasmodium falciparum) Infection in Man

1981 ◽  
Vol 46 (02) ◽  
pp. 547-549 ◽  
Author(s):  
E M Essien ◽  
M I Ebhota
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Infection ◽  
Light Transmission ◽  
Human Platelet ◽  
Platelet Rich Plasma ◽  
Wave Pattern ◽  
Falciparum Infection ◽  
Secondary Wave ◽  
Control Subjects ◽  
The Mean

SummaryDuring acute malaria infection, platelets in human platelet-rich plasma are hypersensitive to the addition of ADP between 1.0 uM and 5.0 uM, or adrenaline 0.11 uM as aggregating agents. The mean maximum aggregation amplitude (as % of light transmission) obtained from 8 subjects in response to added ADP (1.0 uM), 39.8 ± 27 (1SD), was significantly greater than the value in 6 controls (5.2±6.7 (1SD); t = 3, 51 P <0.005). A similar pattern of response was obtained with higher ADP concentrations (2.4,4.5 or 5.0 uM) in 22 patients and 20 control subjects (89.9±14.9% vs 77.8±16.5% (1SD) t = 2.45, P <0.02). Addition of 4.5 uM ADP to patient PRP usually evoked only a single aggregation wave (fused primary and secondary waves) while the typical primary and secondary wave pattern was usually obtained from controls.Mean plasma B-thromboglobulin (BTG) concentration in 7 patients (208.3 ± 15.6 ng/ml) was significantly higher than the value in 6 control subjects (59.2±15.7 ng/ml; t = 13.44, P <0.002).

scholarly journals Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection

2020 ◽  
Vol 1 (9) ◽  
pp. 100157
Author(s):  
Jo-Anne Chan ◽  
Jessica R. Loughland ◽  
Fabian de Labastida Rivera ◽  
Arya SheelaNair ◽  
Dean W. Andrew ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Antibody Production ◽  
Falciparum Infection ◽  
T Follicular Helper Cells ◽  
Plasmodium Falciparum Infection ◽  
Helper Cells ◽  
Follicular Helper

Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers

2006 ◽  
Vol 36 (3) ◽  
pp. 353-360 ◽  
Author(s):  
John B. Sacci ◽  
Uzma Alam ◽  
Donna Douglas ◽  
Jamie Lewis ◽  
D Lorne J. Tyrrell ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Infection ◽  
Plasmodium Falciparum Infection ◽  
Human Livers

scholarly journals Effect of clodronate-liposome injections on Plasmodium falciparum infection in neo-tropical primates Saimiri sciureus

2014 ◽  
Vol 13 (S1) ◽  
Author(s):  
Janaiara A Cunha ◽  
Cesare Bianco-Junior ◽  
Marcelo P Machado ◽  
Pierre Druilhe ◽  
Leonardo JM Carvalho ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Infection ◽  
Saimiri Sciureus ◽  
Plasmodium Falciparum Infection ◽  
Clodronate Liposome

scholarly journals The Use of Mosquito Nets and the Prevalence of Plasmodium falciparum Infection in Rural South Central Somalia

PLoS ONE ◽  
2008 ◽  
Vol 3 (5) ◽  
pp. e2081 ◽  
Author(s):  
Abdisalan M. Noor ◽  
Grainne Moloney ◽  
Mohamed Borle ◽  
Greg W. Fegan ◽  
Tanya Shewchuk ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Infection ◽  
Rural South ◽  
Plasmodium Falciparum Infection ◽  
Mosquito Nets ◽  
South Central

Role of glycans in Plasmodium falciparum infection

1999 ◽  
Vol 27 (4) ◽  
pp. 487-493 ◽  
Author(s):  
A. Barrapn ◽  
D. Spillmann ◽  
J. Carlson ◽  
M. Wahlgren
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Infection ◽  
Plasmodium Falciparum Infection

scholarly journals Antigenicity of the infected-erythrocyte and merozoite surfaces in Falciparum malaria.

1979 ◽  
Vol 150 (5) ◽  
pp. 1241-1254 ◽  
Author(s):  
S G Langreth ◽  
R T Reese
Keyword(s):  
Plasmodium Falciparum ◽  
Falciparum Malaria ◽  
Infected Erythrocyte ◽  
Falciparum Infection ◽  
Human Erythrocytes ◽  
Cross Linking ◽  
Common Antigens

The antigenicity of altered structures induced by Plasmodium falciparum in the membranes of infected Aotus monkey and human erythrocytes was examined. Antisera were obtained from monkeys made immune to malaria. Bound antibodies were shown to be localized on the knob protrusions of infected erythrocytes of both human and monkey origin and from both in vitro and in vivo infections. Therefore, P. falciparum infection has produced similar antigenic changes in the erythrocyte surfaces of both man and monkey. Uninfected erythrocytes and all knobless-infected erythrocytes bound no antibody from immune sera. Strains of P. falciparum from widely different geographic areas that were cultured in vitro in human erythrocytes induced structures (knobs) which have common antigenicity. Merozoites were agglutinated by cross-linking of their cell coats when incubated with immune sera. The binding of ferritin-labeled antibody was heavy on the coats of both homologous and heterologous strains of the parasite, indicating that the merozoite surfaces of these strains share common antigens.

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