First report of interruption of mast cell degranulation and endothelial cells activation by anti-inflammatory drugs controlling the acute response provoked by Pseudoplatystoma fasciatum fish venom

Toxicon ◽  
2014 ◽  
Vol 90 ◽  
pp. 237-248 ◽  
Author(s):  
Mônica Lopes-Ferreira ◽  
Eduardo Martins Gomes ◽  
Fernanda Miriani Bruni ◽  
Marcio Jose Ferreira ◽  
Patrícia Charvet ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Mast Cell ◽  
Mast Cell Degranulation ◽  
First Report ◽  
Acute Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory and Antinociceptive Activity of Ouabain in Mice

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Danielle Ingrid Bezerra de Vasconcelos ◽  
Jacqueline Alves Leite ◽  
Luciana Teles Carneiro ◽  
Márcia Regina Piuvezam ◽  
Maria Raquel Vitorino de Lima ◽  
...  
Keyword(s):  
Immune Response ◽  
Mast Cell ◽  
Inflammatory Process ◽  
Mast Cell Degranulation ◽  
Regulatory Mechanisms ◽  
Antinociceptive Activity ◽  
Paw Edema ◽  
Anti Inflammatory ◽  
First Time

Ouabain, an inhibitor of the Na+/K+-ATPase pump, was identified as an endogenous substance of human plasma. Ouabain has been studied for its ability to interfere with various regulatory mechanisms. Despite the studies portraying the ability of ouabain to modulate the immune response, little is known about the effect of this substance on the inflammatory process. The aim of this work was to study the effects triggered by ouabain on inflammation and nociceptive models. Ouabain produced a reduction in the mouse paw edema induced by carrageenan, compound 48/80 and zymosan. This anti-inflammatory potential might be related to the inhibition of prostaglandin E2, bradykinin, and mast-cell degranulation but not to histamine. Ouabain also modulated the inflammation induced by concanavalin A by inhibiting cell migration. Besides that, ouabain presented antinociceptive activity. Taken these data together, this work demonstrated, for the first time, that ouabain presentedin vivoanalgesic and anti-inflammatory effects.

scholarly journals Dihydroavenanthramide D inhibits mast cell degranulation and exhibits anti-inflammatory effects through the activation of neurokinin-1 receptor

2017 ◽  
Vol 26 (8) ◽  
pp. 739-742 ◽  
Author(s):  
Tobias Lotts ◽  
Konstantin Agelopoulos ◽  
Ngoc Q. Phan ◽  
Karin Loser ◽  
Gerhard Schmaus ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mast Cell Degranulation ◽  
Neurokinin 1 Receptor ◽  
Anti Inflammatory ◽  
Neurokinin 1

Stronger inhibition by nonsteroid anti‐inflammatory drugs of cyclooxygenase‐1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events

2006 ◽  
Vol 20 (14) ◽  
pp. 2468-2475 ◽  
Author(s):  
Jane A. Mitchell ◽  
Ruth Lucas ◽  
Ivana Vojnovic ◽  
Kamrul Hasan ◽  
John R. Pepper ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cyclooxygenase 1 ◽  
Increased Risk ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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