Polycyclic aromatic hydrocarbons in consumer products—Metabolism and toxicity in human skin

2009 ◽  
Vol 189 ◽  
pp. S203
Author(s):  
Kristin Stolpmann ◽  
Frank Henkler ◽  
Christoph Hutzler ◽  
Dhimant Desai ◽  
Shantu Amin ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Human Skin ◽  
Aromatic Hydrocarbons ◽  
Consumer Products ◽  
Polycyclic Aromatic

scholarly journals Metabolism and genotoxicity of polycyclic aromatic hydrocarbons in human skin explants: mixture effects and modulation by sunlight

2019 ◽  
Vol 94 (2) ◽  
pp. 495-507
Author(s):  
Anne von Koschembahr ◽  
Antonia Youssef ◽  
David Béal ◽  
Etienne Bourgart ◽  
Alex Rivier ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Human Skin ◽  
Aromatic Hydrocarbons ◽  
Mixture Effects ◽  
Polycyclic Aromatic ◽  
Skin Explants

scholarly journals Toxification of polycyclic aromatic hydrocarbons by commensal bacteria from human skin

2017 ◽  
Vol 91 (6) ◽  
pp. 2331-2341 ◽  
Author(s):  
Juliane Sowada ◽  
Lisa Lemoine ◽  
Karsten Schön ◽  
Christoph Hutzler ◽  
Andreas Luch ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Human Skin ◽  
Aromatic Hydrocarbons ◽  
Commensal Bacteria ◽  
Polycyclic Aromatic

Polycyclic Aromatic Hydrocarbons in Newspaper Inks: Migration, Metabolism, and Genotoxicity in Human Skin

2014 ◽  
Vol 35 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Meike Paschke ◽  
Christoph Hutzler ◽  
Joep Brinkmann ◽  
Frank Henkler ◽  
Andreas Luch
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Human Skin ◽  
Aromatic Hydrocarbons ◽  
Polycyclic Aromatic

scholarly journals Development of a certified reference material for the determination of polycyclic aromatic hydrocarbons (PAHs) in rubber toy

2021 ◽  
Author(s):  
Thomas Sommerfeld ◽  
Christian Jung ◽  
Juliane Riedel ◽  
Tatjana Mauch ◽  
Andreas Sauer ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Consumer Products ◽  
Gas Chromatography Mass Spectrometry ◽  
Isotope Dilution Analysis ◽  
Chemical Safety ◽  
Stable Isotope Dilution Analysis ◽  
Mass Fractions ◽  
Polycyclic Aromatic

AbstractPolycyclic aromatic hydrocarbons (PAHs) are a large group of priority organic pollutants, which contaminate environmental compartments, food, and consumer products as well. Due to their frequent occurrence associated with elevated levels of PAHs, plastic and rubber parts of consumer products and toys are particular sources of exposure. Although European maximum levels exist for eight carcinogenic PAHs in consumer products and toys according to REACH Regulation (EC) No. 1907/2006, certified reference materials (CRM) are still not available. To overcome this lack, the first CRM for the determination of PAHs in rubber toys (BAM-B001) was developed according to the requirements of ISO Guide 35. The whole process of CRM development including preparation, homogeneity and stability studies, and value assignment is presented. The assignment of the certified mass fractions was based upon in-house study at BAM using stable isotope dilution analysis (SIDA) gas chromatography mass spectrometry (GC–MS). The obtained values were confirmed by the results of two interlaboratory comparison (ILC) studies with more than 50 expert laboratories from Germany and China. The mass fractions of 14 PAHs including all REACH and GS mark regulated compounds were certified ranging between 0.2 and 15.4 mg/kg accompanied by expanded uncertainties (coverage factor k = 2). In addition, informative values were determined for 4 PAHs, mainly due to higher uncertainties and/or lack of ILC data for confirmation. BAM-B001 is intended for analytical quality control particularly based on the AfPS GS 2019:01 PAK method and contributes to improve the chemical safety of consumer products including toys. Graphical abstract

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