Antigenotoxic effect of mangosteen juice on the DNA damage induced by daunorubicin in mouse

2016 ◽  
Vol 258 ◽  
pp. S160 ◽  
Author(s):  
D. Castilla Burguete ◽  
R. Xavier Castro ◽  
G. Pardo Rosich ◽  
A. Vergara Castañeda ◽  
L. Martino Roaro
Keyword(s):  
Dna Damage ◽  
Antigenotoxic Effect

Antigenotoxic Effect of Kefir and Ayran Supernatants on Fecal Water-Induced DNA Damage in Human Colon Cells

2010 ◽  
pp. 1-1 ◽  
Author(s):  
Anna Grishina ◽  
Irina Kulikova ◽  
Ludmila Alieva ◽  
Andrew Dodson ◽  
Ian Rowland ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Colon ◽  
Colon Cells ◽  
Fecal Water ◽  
Antigenotoxic Effect

Antigenotoxic Effect Against Ultraviolet Radiation-induced DNA Damage of the Essential Oils fromLippiaSpecies

2017 ◽  
Vol 93 (4) ◽  
pp. 1063-1072 ◽  
Author(s):  
Nathalia Quintero Ruiz ◽  
Yuri Córdoba Campo ◽  
Elena E. Stashenko ◽  
Jorge Luis Fuentes
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Essential Oils ◽  
Radiation Induced ◽  
Antigenotoxic Effect

scholarly journals Evaluation of genotoxic and antigenotoxic properties of essential oils of Seseli rigidum Waldst. & Kit. (Apiaceae)

2016 ◽  
Vol 68 (1) ◽  
pp. 135-144 ◽  
Author(s):  
Lada Zivkovic ◽  
Andrea Cabarkapa ◽  
Mirjana Marcetic ◽  
Nada Kovacevic ◽  
Vladan Bajic ◽  
...  
Keyword(s):  
Dna Damage ◽  
Essential Oils ◽  
Biological Activities ◽  
Post Treatment ◽  
Natural Habitats ◽  
Main Compound ◽  
Beneficial Effects ◽  
Repair Mechanisms ◽  
Antigenotoxic Effect

The essential oils of genus Seseli are known for their beneficial biological activities and could present novel targets in the development of safe and effective preparations of plant products. The objective was to test the essential oils of different parts of Seseli rigidum from two natural habitats for potential genotoxic and antigenotoxic activities against H202-induced DNA damage in human whole blood cells in vitro, by the comet assay. The essential oil analysis showed a high falcarinol content in oil from the root, while oils of the fruit and aerial parts contained ?-pinene as the main compound. Genotoxicity was not detected at any of the concentrations of the essential oils from the three parts of the plant from localities I and II. Although the antioxidant activity (established by the FRAP and DPPH tests) of the investigated oils was low, all oils demonstrated a strong antigenotoxic effect against H2O2-induced damage post-treatment, when the oils were applied after the oxidant. Based on the lack of pretreatment activity and the post-treatment reduction in DNA damage, the antigenotoxic effect of S. rigidum essential oils was probably based on the stimulation of DNA repair mechanisms. Environmental conditions did not affect the antigenotoxic properties of the oils. In conclusion, our results revealed the antigenotoxic properties of S. rigidum essential oils and appropriate and safe doses with beneficial effects under the described conditions.

scholarly journals Antigenotoxic Effect of Curcumin and Carvacrol against Parathion Induced DNA Damage in Cultured Human Peripheral Blood Lymphocytes and Its Relation to GSTM1 and GSTT1 Polymorphism

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Neeraj Kumar ◽  
Anita Yadav ◽  
Sachin Gulati ◽  
Kanupriya ◽  
Neeraj Aggarwal ◽  
...  
Keyword(s):  
Dna Damage ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Organophosphorus Pesticides ◽  
Peripheral Blood Lymphocytes ◽  
Sister Chromatid Exchanges ◽  
Blood Lymphocytes ◽  
Agricultural Pesticides ◽  
Chromatid Exchanges ◽  
Antigenotoxic Effect

In recent years, the use of organophosphorus pesticides has been extensively increased and these compounds signify a major class of agricultural pesticides today. We studied antigenotoxic potential of curcumin and carvacrol against the parathion induced DNA damage in cultured peripheral blood lymphocytes using sister chromatid exchanges as a biomarker of genotoxicity. Heparinised fresh blood from healthy individuals was treated with 2.5 μg/mL concentration of parathion in presence of curcumin and carvacrol in order to observe the antigenotoxic potential of both curcumin and carvacrol. Significant reduction(P<0.05)was observed in the frequencies of SCEs in presence of 10 μg/mL and 15 μg/mL concentrations of curcumin as compared to parathion exposed sample. Similarly carvacrol had significant(P<0.05)antigenotoxic effect at the concentrations of 2.5 μg/mL and 5.0 μg/mL against the parathion. We also studied the effect of GSTT1 and GSTM1 on genotoxicity of parathion and antigenotoxic potential of curcumin and carvacrol. We did not observe any significant effect(P>0.05)of GSTT1 and GSTM1 polymorphism on genotoxicity of parathion and antigenotoxic potential of curcumin and carvacrol.

scholarly journals Antigenotoxic Effect ofTrametesspp. Extracts against DNA Damage on Human Peripheral White Blood Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Aleksandar Knežević ◽  
Lada Živković ◽  
Mirjana Stajić ◽  
Jelena Vukojević ◽  
Ivan Milovanović ◽  
...  
Keyword(s):  
Dna Damage ◽  
Blood Cells ◽  
Conventional Medicine ◽  
White Blood Cells ◽  
Dpph Assay ◽  
Strand Breaks ◽  
Dna Migration ◽  
Dna Strand ◽  
Peripheral White Blood Cells ◽  
Antigenotoxic Effect

Trametesspecies have been used for thousands of years in traditional and conventional medicine for the treatment of various types of diseases. The goal was to evaluate possible antigenotoxic effects of mycelium and basidiocarp extracts of selectedTrametesspecies and to assess dependence on their antioxidant potential.Trametes versicolor, T. hirsuta, andT. gibbosawere the species studied. Antigenotoxic potentials of extracts were assessed on human peripheral white blood cells with basidiocarp and mycelium extracts of the species. The alkaline comet test was used for detection of DNA strand breaks and alkali-labile sites, as well as the extent of DNA migration. DPPH assay was used to estimate antioxidative properties of extracts. Fruiting body extracts ofT. versicolorandT. gibbosaas well asT. hirsutaextracts, except that at 20.0 mg/mL, were not genotoxic agents.T. versicolorextract had at 5.0 mg/mL the greatest antigenotoxic effect in both pre- and posttreatment of leukocytes. The mycelium extracts of the three species had no genotoxic activity and significant antigenotoxic effect against H2O2-induced DNA damage, both in pre- and posttreatment. The results suggest that extracts of these three species could be considered as strong antigenotoxic agents able to stimulate genoprotective response of cells.

1576: Prediction of Spermatozoal DNA Damage by a Novel Semen Quality Score

2004 ◽  
Vol 171 (4S) ◽  
pp. 416-416
Author(s):  
Tamer M. Said ◽  
Shyam Allamaneni ◽  
Kiran P. Nallella ◽  
Rakesh K. Sharma ◽  
Sijo J. Parekattil ◽  
...  
Keyword(s):  
Dna Damage ◽  
Semen Quality ◽  
Quality Score

A safe fix for alcohol-derived DNA damage

Nature ◽  
2020 ◽  
Vol 579 (7800) ◽  
pp. 499-500
Author(s):  
Irene Gallina ◽  
Julien P. Duxin
Keyword(s):  
Dna Damage
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