Chlorocholine chloride induced testosterone secretion inhibition mediated by endoplasmic reticulum stress in primary Leydig cells

2021 ◽  
Author(s):  
Qianqian Xiao ◽  
Xiaohong Hou ◽  
Chenping Kang ◽  
Linglu Xu ◽  
Lilan Yuan ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Leydig Cells ◽  
Chlorocholine Chloride ◽  
Testosterone Secretion ◽  
Secretion Inhibition

scholarly journals HC diet inhibited testosterone synthesis by activating endoplasmic reticulum stress in testicular Leydig cells

2019 ◽  
Vol 23 (5) ◽  
pp. 3140-3150 ◽  
Author(s):  
Chunxiao Yu ◽  
Fangjie Jiang ◽  
Meijie Zhang ◽  
Dandan Luo ◽  
Shanshan Shao ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Leydig Cells ◽  
Testosterone Synthesis

Smooth endoplasmic reticulum in perfusion and immersion-fixed Leydig cells

1990 ◽  
Vol 48 (3) ◽  
pp. 82-83
Author(s):  
R.T.F. Bernard ◽  
R.H.M. Cross
Keyword(s):  
Endoplasmic Reticulum ◽  
Electron Microscope ◽  
Steroid Hormones ◽  
Transmission Electron Microscope ◽  
Leydig Cells ◽  
Smooth Endoplasmic Reticulum ◽  
Random Mixture ◽  
Transmission Electron

Smooth endoplasmic reticulum (SER) is involved in the biosynthesis of steroid hormones, and changes in the organisation and abundance of this organelle are regularly used as indicators of changes in the level of steroidogenesis. SER is typically arranged as a meshwork of anastomosing tubules which, with the transmission electron microscope, appear as a random mixture of cross, oblique and longitudinal sections. Less commonly the SER appears as swollen vesicles and it is generally suggested that this is an artefact caused during immersion fixation or during immersion of poorly-perfused tissue.During a previous study of the Leydig cells of a seasonally reproducing bat, in which tissue was fixed by immersion, we noted that tubular SER and vesicular SER often occured in adjacent cells and sometimes in the same cell, and that the abundance of the two types of SER changed seasonally. We came to doubt the widelyheld dogma that vesicular SER was an artefact of immersion fixation and set out to test the hypothesis that the method of fixation does not modify the ultrastructure of the SER.

Abstract #403: The Glutathione Mimic Ebselen Inhibits Oxidative Stress but not Endoplasmic Reticulum Stress in Endothelial Cells.

2015 ◽  
Vol 21 ◽  
pp. 85-86
Author(s):  
William Kurban ◽  
Salma Makhoul Ahwach ◽  
Melanie Thomas ◽  
Luisa Onsteed-Haas ◽  
Michael Haas
Keyword(s):  
Oxidative Stress ◽  
Endothelial Cells ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress
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