Next-generation sequencing technology a new tool for killer cell immunoglobulin-like receptor allele typing in hematopoietic stem cell transplantation

2018 ◽  
Vol 25 (1) ◽  
pp. 87-89 ◽  
Author(s):  
B. Maniangou ◽  
C. Retière ◽  
K. Gagne
Keyword(s):  
Stem Cell ◽  
Next Generation Sequencing ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Killer Cell ◽  
Sequencing Technology ◽  
Hematopoietic Stem ◽  
Next Generation Sequencing Technology ◽  
Generation Sequencing

scholarly journals Role of HLA in Hematopoietic Stem Cell Transplantation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Meerim Park ◽  
Jong Jin Seo
Keyword(s):  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Critical Role ◽  
Killer Cell ◽  
Human Leukocyte ◽  
Hematopoietic Stem

The selection of hematopoietic stem cell transplantation (HSCT) donors includes a rigorous assessment of the availability and human leukocyte antigen (HLA) match status of donors. HLA plays a critical role in HSCT, but its involvement in HSCT is constantly in flux because of changing technologies and variations in clinical transplantation results. The increased availability of HSCT through the use of HLA-mismatched related and unrelated donors is feasible with a more complete understanding of permissible HLA mismatches and the role of killer-cell immunoglobulin-like receptor (KIR) genes in HSCT. The influence of nongenetic factors on the tolerability of HLA mismatching has recently become evident, demonstrating a need for the integration of both genetic and nongenetic variables in donor selection.

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