Time-dependent variations in inflammation and scar formation of six different pubovaginal sling materials in the rabbit model

Urology ◽  
2006 ◽  
Vol 67 (5) ◽  
pp. 1105-1110 ◽  
Author(s):  
Amy E. Krambeck ◽  
Chandler D. Dora ◽  
Thomas J. Sebo ◽  
Audrey L. Rohlinger ◽  
David S. DiMarco ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Scar Formation ◽  
Pubovaginal Sling ◽  
Time Dependent

Intravitreal Ceftazidime in a Rabbit Model: Dose- and Time-Dependent Toxicity and Pharmacokinetic Analysis

1987 ◽  
Vol 3 (3) ◽  
pp. 257-262 ◽  
Author(s):  
WALTER M. JAY ◽  
PEGGY FISHMAN ◽  
MERVAT AZIZ ◽  
ROBERT K. SHOCKLEY
Keyword(s):  
Rabbit Model ◽  
Time Dependent ◽  
Pharmacokinetic Analysis

R400 – Effects of Silicone Gel Sheeting on Scar Formation

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P177-P177
Author(s):  
Shervin Aminpour ◽  
Travis T Tollefson
Keyword(s):  
Histological Analysis ◽  
Normal Skin ◽  
Rabbit Model ◽  
Study Groups ◽  
Scar Formation ◽  
Hypertrophic Scarring ◽  
Silicone Gel ◽  
Facial Plastic ◽  
Silicone Gel Sheeting ◽  
Scar Hypertrophy

Problem The treatment of keloids and hypertrophic scars has long been a concern for facial plastic surgeons. There are a wide variety of over-the-counter products that claim to improve hypertrophic scarring. Post-surgical patients often inquire as to which of these products will give the best cosmetic result. Silicone gel sheeting is reported to provide positive outcomes with respect to a reduction in scar hypertrophy and an improvement in color differences. The exact mechanism is unknown. Micropore (3M) tape, a cheaper and more readily available product, has also been reported to reduce scar hypertrophy. This study will evaluate the differences and effectiveness of silicone gel sheeting and micropore tape in the reduction of scar hypertrophy in an animal model of scarring. Methods Hypertrophic scar formation was induced in an established rabbit model that parallels human skin. Treatment of the animals' scars was divided into 3 study groups: silicone gel sheeting, micropore tape, or no treatment. 80 total scars were treated for 30 days after the complete reepithelialization of the created scars. Both photometric and histologic analysis was performed on the scars. Scar hypertrophy was analyzed with blinded observers using a visual analog scale. Histological analysis was performed using the Scar Elevation Index, a ratio of the scar height over normal skin. Results Both photographic and histological analysis showed there was a statistically significant improvement (p<0.05) in scar hypertrophy after use of either silicone gel sheeting and micropore tape when compared with controls. Conclusion Silicone Gel Sheeting and Micropore Tape are equally effective in the reduction of hypertrophic scarring. Significance Facial plastic surgeons should consider covering facial incisions with micropore tape for 30 days after surgery to minimize the risk of hypertrophic scarring.

Time-dependent up-regulation of neuronal 5-hydroxytryptamine binding sites in the detrusor of a rabbit model of partial bladder outlet obstruction

1999 ◽  
Vol 17 (5) ◽  
pp. 255-260 ◽  
Author(s):  
Masood A. Khan ◽  
Mick R. Dashwood ◽  
Cecil S. Thompson ◽  
Faiz H. Mumtaz ◽  
Robert J. Morgan ◽  
...  
Keyword(s):  
Binding Sites ◽  
Bladder Outlet Obstruction ◽  
Rabbit Model ◽  
Outlet Obstruction ◽  
Time Dependent ◽  
Partial Bladder Outlet Obstruction

scholarly journals Adverse Impact of Diet-Induced Hypercholesterolemia on Cardiovascular Tissue Homeostasis in a Rabbit Model: Time-Dependent Changes in Cardiac Parameters

2013 ◽  
Vol 14 (9) ◽  
pp. 19086-19108 ◽  
Author(s):  
Attila Kertész ◽  
Mariann Bombicz ◽  
Daniel Priksz ◽  
Jozsef Balla ◽  
Gyorgy Balla ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Tissue Homeostasis ◽  
Time Dependent ◽  
Adverse Impact ◽  
Cardiovascular Tissue

Time-Dependent Changes in Biomechanical Properties of Four Different Synthetic Materials in a Rabbit Model and the Importance in Respect to Sling Surgery

2008 ◽  
Vol 81 (4) ◽  
pp. 456-461 ◽  
Author(s):  
Ali Fuat Atmaca ◽  
Ege Can Şerefoğlu ◽  
Muzaffer Eroğlu ◽  
Mesut Gürdal ◽  
Ahmet Metin ◽  
...  
Keyword(s):  
Rabbit Model ◽  
Biomechanical Properties ◽  
Time Dependent ◽  
Synthetic Materials ◽  
Sling Surgery

scholarly journals The Role of Intravitreal Anti-VEGF Agents in Rabbit Eye Model of Open-Globe Injury

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Xiao Zhao ◽  
Han Han ◽  
Yinting Song ◽  
Mei Du ◽  
Mengyu Liao ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Rabbit Model ◽  
Scar Formation ◽  
Enzyme Linked Immunosorbent Assay ◽  
Open Globe Injury ◽  
Anti Vegf ◽  
Open Globe

Purpose. To evaluate the effects of intravitreal anti-VEGF agents in a rabbit model of open-globe injury (OGI). Methods. OGI was induced in the right eyes of 75 Belgian rabbits by making 5 mm circumferential incision placed 6 mm behind the limbus. The rabbits were divided into 4 groups: control (n = 5), OGI group (n = 40), and intravitreal Ranibizumab and Conbercept (n = 15 each). Ranibizumab or Conbercept was injected into the vitreous at 0.5 hours, 3 days, or 7 days. Vitreous fluid was collected, and levels of growth factors and cytokines were measured by enzyme-linked immunosorbent assay (ELISA). On day 28 after OGI, B scan examination and histological examination were performed to evaluate intravitreal proliferation and formation of epiretinal fibrosis. Results. Vitreous levels of vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), transforming growth factor-beta (TGF-β), and plasminogen activator inhibitor-1 (PAI-1) were significantly increased in rabbit eyes after OGI. Compared to eyes in OGI group, anti-VEGF treatments significantly reduced these growth factors and cytokines. Among the 7 eyes examined from each group for intravitreal proliferative changes, they were found in 7 of 7 (100%) in OGI group and were decreased by Ranibizumab and Conbercept to 5 of 7 (71.4%) and 4 of 7 (57.1%), respectively. Both Ranibizumab and Conbercept inhibited epiretinal scar formation at the wound site, with Conbercept showing the greatest effect (maximal length of scar (L), LOGI = 503 ± 82.44 μm, LRanibizumab = 355 ± 43.66 μm, and LConbercept = 250.33 ± 36.02 μm). Conclusion. Anti-VEGF treatments after OGI significantly attenuated the upregulation of growth factors and cytokines in the vitreous and prevented intravitreal proliferation and epiretinal scar formation and thus may protect against the development of posttraumatic complications such as proliferative vitreoretinopathy (PVR).

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