The loss of BAP1 protein expression predicts poor prognosis in patients with nonmetastatic clear cell renal cell carcinoma with inferior vena cava tumor thrombosis

2018 ◽  
Vol 36 (8) ◽  
pp. 365.e9-365.e14 ◽  
Author(s):  
Suguru Oka ◽  
Naoko Inoshita ◽  
Yuji Miura ◽  
Ryosuke Oki ◽  
Yu Miyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Protein Expression ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Inferior Vena ◽  
Clear Cell ◽  
Vena Cava ◽  
Cell Renal Cell Carcinoma ◽  
Tumor Thrombosis

Prognostic value of BAP1 expression in clear cell renal cell carcinoma with inferior vena cava tumor thrombosis.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. e16080-e16080
Author(s):  
Suguru Oka ◽  
Naoko Inoshita ◽  
Yuji Miura ◽  
Ryosuke Oki ◽  
Yu Miyama ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Renal Cell ◽  
Radical Nephrectomy ◽  
Poor Prognosis ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Clear Cell ◽  
Vena Cava ◽  
Ivc Tumor

e16080 Background: Renal cell carcinoma (RCC) is characterized by a propensity for extension into the renal vein and inferior vena cava (IVC), and affected patients have a poor prognosis. BAP1 mutation, which occurs in about 15% of patients with clear cell RCC (ccRCC), also predicts a poor prognosis. The aim of this study was to elucidate the association between BAP1 expression and clinicopathologic outcomes in patients with ccRCC with an IVC tumor thrombus. Methods: Thirty-nine patients with ccRCC with an IVC tumor thrombus who underwent radical nephrectomy and tumor thrombectomy at our institution from 1999 to 2010 were retrospectively evaluated. Immunohistochemical analyses were performed for the expression of BAP1, and the associations between the expression of BAP1 and clinical outcomes were assessed. Survival analyses were performed using the Kaplan–Meier method and log-rank test. Multivariate analyses of the associations between overall survival (OS) and clinical variables were performed using a Cox proportional hazard model. For all analyses, P < 0.05 was considered statistically significant. Results: The median follow-up time was 58.8 months (range, 2–130 months). The median age was 66 years (range, 37–80 years). Four patients (10.3%) had lung metastasis at the initial diagnosis. The primary tumor was right-sided in 27 (69.2%) patients and left-sided in 12 (30.8%). The IVC tumor thrombus extended above and below the diaphragm in 11 (28.2%) and 28 (71.8%) patients, respectively. The KPS score was > 80 in 23 patients (59.0%). BAP1 expression was positive in 26 (67.0%) cases and negative in 13 (33.0%). BAP1-negative tumors were associated with a significantly shorter OS than BAP1-positive tumors (median OS, 42.0 vs. 81.5 months, respectively; P = 0.019). The median disease-free survival in BAP1-negative and -positive tumors was 10.0 and 19.0 months, respectively (P = 0.019). Multivariate analysis showed that only a BAP1-negative status was significantly associated with shorter OS (P = 0.026). Conclusions: A BAP1-negative tumor status was significantly associated with a poor prognosis in patients with ccRCC with an IVC tumor thrombus who underwent radical nephrectomy and tumor thrombectomy.

scholarly journals Impact of miR-21, miR-126 and miR-221 as Prognostic Factors of Clear Cell Renal Cell Carcinoma with Tumor Thrombus of the Inferior Vena Cava

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e109877 ◽  
Author(s):  
Daniel Claudius Vergho ◽  
Susanne Kneitz ◽  
Charis Kalogirou ◽  
Maximilian Burger ◽  
Markus Krebs ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Prognostic Factors ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Clear Cell ◽  
Vena Cava ◽  
Cell Renal Cell Carcinoma

Loss of nuclear BAP1 protein expression is a marker of poor prognosis in patients with clear cell renal cell carcinoma

2016 ◽  
Vol 34 (8) ◽  
pp. 338.e11-338.e18 ◽  
Author(s):  
Daniele Minardi ◽  
Guendalina Lucarini ◽  
Giulio Milanese ◽  
Roberto Di Primio ◽  
Rodolfo Montironi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

scholarly journals Skeletal Muscle Metastases and Inferior Vena Cava Involvement in a Patient with Clear Cell Renal Cell Carcinoma and Sarcomatoid Differentiation

2016 ◽  
Vol 1 (2) ◽  
pp. 197-200
Author(s):  
Călin Molnar ◽  
Octavian-Sabin Tătaru ◽  
Lucian Mărginean ◽  
Angela Borda
Keyword(s):  
Skeletal Muscle ◽  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Renal Cell ◽  
Renal Vein ◽  
Inferior Vena ◽  
Clear Cell ◽  
Vena Cava ◽  
The Right ◽  
Sarcomatoid Differentiation

Abstract Introduction: Renal cell carcinoma has a propensity to propagate into the renal vein and inferior vena cava. A small percentage has distant metastasis at presentation. Pulmonary, hepatic, cerebral and bone metastases are common, but skeletal muscle involvement is rare. Case presentation: We present the case of a 51-year-old patient complaining of right flank pain, gross hematuria and a painful left laterothoracic mass. Preoperative examination revealed a tumor in the inferior pole of the right kidney, thrombosis of the right renal vein that extended into the inferior vena cava and a left laterothoracic tumor. We decided on a preoperative digital subtraction angiography and selected embolization of the laterothoracic mass. We performed right radical nephrectomy with vena cava thrombus excision and excision of the left laterothoracic tumor. The pathological examination revealed a clear cell renal carcinoma with sarcomatoid differentiation of the right kidney. Metastases with the above features were noticed in the right adrenal gland and in the skeletal muscle of the chest wall. Conclusions: The surgical resection of large renal tumors with associated thrombus within the inferior vena cava is challenging to any surgeon. The preoperative embolization of the metastatic tumor is helpful in the reduction of pain and intraoperative blood loss.

scholarly journals Surgically Discovered Xanthogranulomatous Pyelonephritis Invading Inferior Vena Cava with Coexisting Renal Cell Carcinoma

2009 ◽  
Vol 9 ◽  
pp. 5-9 ◽  
Author(s):  
Henry M. Rosevear ◽  
Melissa M. Meier ◽  
Brian L. Gallagher ◽  
Fadi N. Joudi
Keyword(s):  
Renal Cell Carcinoma ◽  
Inferior Vena Cava ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Inflammatory Process ◽  
Inferior Vena ◽  
Vena Cava ◽  
Posterior Wall ◽  
Xanthogranulomatous Pyelonephritis ◽  
Cell Renal Cell Carcinoma

Xanthogranulomatous pyelonephritis (XGP) is a chronic inflammatory process that results in replacement of renal and/or perirenal tissue with a diffuse infiltrate of inflammatory cells referred to as xanthoma cells. We present a case of a 49-year-old man with an incidentally discovered renal mass with inferior vena cava (IVC) thrombus, who was found intraoperatively to have a significant inflammatory process involving the posterior wall of his IVC and right renal vein consistent with XGP surrounding a focus of clear cell renal cell carcinoma in the midportion of his right kidney.

scholarly journals Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma

Cancer ◽  
2013 ◽  
Vol 120 (7) ◽  
pp. 1059-1067 ◽  
Author(s):  
Richard W. Joseph ◽  
Payal Kapur ◽  
Daniel J. Serie ◽  
Jeanette E. Eckel-Passow ◽  
Mansi Parasramka ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Clear Cell ◽  
Low Risk ◽  
Cell Renal Cell Carcinoma ◽  
Independent Marker

scholarly journals Multidisciplinary surgical treatment of clear-cell renal carcinoma with inferior vena cava tumor thrombus level III and IV: our experience during the past decade

2020 ◽  
Vol 48 (2-3) ◽  
pp. 68-72
Author(s):  
Tvrtko Hudolin ◽  
◽  
Vladimir Ferenčak ◽  
Luka Penezić ◽  
Toni Zekulić ◽  
...  
Keyword(s):  
Inferior Vena Cava ◽  
Renal Cell ◽  
Tumor Thrombus ◽  
Inferior Vena ◽  
Clear Cell ◽  
Cell Cancer ◽  
Vena Cava ◽  
Cell Renal Cell Carcinoma ◽  
Cell Renal Carcinoma ◽  
Primary Determinant

Patients with non-metastatic, stage T3 clear-cell renal cell cancer present a clinical challenge for urologists. The extent of tumor thrombus in inferior vena cava is the primary determinant of surgical procedure complexity. Level III and IV thrombi require the use of cardiopulmonary bypass and hypothermic arrest. Careful preoperative planning and a multidisciplinary approach are mandatory. In this paper, we report outcomes of 12 patients who were surgically treated in our center. The 29 months overall survival for all patients was 69%, while three patients died during follow-up. Of nine surviving patients, six are currently disease-free, whereas three had disease progression. Our study showed that carefully selected patients with clear-cell renal cell carcinoma with inferior vena cava tumor thrombus level III and IV could be successfully treated with an aggressive surgical approach.

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