Adjuvant effect of Cliptox™ on the protective immune response induced by an inactivated vaccine against foot and mouth disease virus in mice

Vaccine ◽  
2010 ◽  
Vol 28 (38) ◽  
pp. 6361-6366 ◽  
Author(s):  
A. Batista ◽  
V. Quattrocchi ◽  
V. Olivera ◽  
C. Langellotti ◽  
J.S. Pappalardo ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Protective Immune Response ◽  
Inactivated Vaccine ◽  
Adjuvant Effect ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Antigenic sites of foot-and-mouth disease virus (FMDV): an analysis of the specificities of anti-FMDV antibodies after vaccination of naturally susceptible host species

2002 ◽  
Vol 83 (4) ◽  
pp. 775-782 ◽  
Author(s):  
N. Aggarwal ◽  
P. V. Barnett
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Protective Immune Response ◽  
Susceptible Host ◽  
Ruminant Species ◽  
Antigenic Sites ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Of the known neutralizing antigenic sites of foot-and-mouth disease virus (FMDV), site 1 or A, formed in part by the G–H loop of VP1, has historically been considered immunodominant because of evidence implicating its importance in the induction of a protective immune response. However, no systematic study has been done to determine the relative importance of the various specificities of antibodies against the known neutralizing antigenic sites of FMDV in the polyclonal immune response of a natural host after vaccination. In this report, we have adopted a monoclonal antibody-based competition ELISA and used antibodies specific to sites 1, 2 and 3 to provide some insight into this issue. Following vaccination of the three main target species, cattle, pigs and sheep, with an O1 serotype strain, results indicate that none of these three antigenic sites can be considered immunodominant in a polyclonal serum. Interestingly, pigs did not respond to epitopes on the carboxy terminus end of VP1 as efficiently as the ruminant species. In addition to the known sites, other as yet undefined sites might also be important in the induction of a protective immune response. Possible implications for the design of new vaccine strategies for foot-and-mouth disease are discussed.

Biomineralization improves the thermostability of foot-and-mouth disease virus-like particles and the protective immune response induced

Nanoscale ◽  
2019 ◽  
Vol 11 (47) ◽  
pp. 22748-22761 ◽  
Author(s):  
Ping Du ◽  
Ronghuan Liu ◽  
Shiqi Sun ◽  
Hu Dong ◽  
Ruibo Zhao ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Immune Activation ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Protective Immune Response ◽  
Virus Like Particles ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Schematic description of immune activation of DCs of the thermostable biomineralized VLPs.

scholarly journals Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation

Viruses ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 3954-3973 ◽  
Author(s):  
Belén Borrego ◽  
Miguel Rodríguez-Pulido ◽  
Concepción Revilla ◽  
Belén Álvarez ◽  
Francisco Sobrino ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Innate Immune Response ◽  
Foot And Mouth Disease ◽  
Virus Genome ◽  
Mouth Disease ◽  
Innate Immune ◽  
Structural Domains ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Selective Lymphocyte Depletion during the Early Stage of the Immune Response to Foot-and-Mouth Disease Virus Infection in Swine

2006 ◽  
Vol 80 (5) ◽  
pp. 2369-2379 ◽  
Author(s):  
Fayna Díaz-San Segundo ◽  
Francisco J. Salguero ◽  
Ana de Avila ◽  
M. Mar Fernández de Marco ◽  
Miguel A. Sánchez-Martín ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Disease Virus ◽  
Ex Vivo ◽  
Early Stage ◽  
Foot And Mouth Disease ◽  
Analytical Techniques ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth

ABSTRACT Foot-and-mouth disease virus (FMDV) is the causative agent of a highly contagious vesicular disease of cloven-hoofed animals. In the present study we use FMDV serotype C infection of swine to determine, by analytical techniques, the direct ex vivo visualization of virus-infected immune cells during the first 17 days of infection. We report, for the first time, that FMDV C-S8c1 can infect T and B cells at short periods of time postinoculation, corresponding with the peak of the viremia. There is a significant lymphopenia that involves CD3+ CD4− CD8+/−, CD3+ CD4− CD8+Tc, and CD3+ CD4+ CD8+ memory Th but not CD3+ CD4+ CD8− naïve Th lymphocytes. In addition, a profound depletion of the vast majority of peripheral T cells in lymph nodes and spleen is observed. This selective depletion of T cells is not due mainly to in situ death via apoptosis as visualized by the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling (TUNEL) technique. Thus, early infection of T cells by FMDV may be the main cause of the observed T-cell depletion. Importantly, this lack of T cells is reflected in a reduced response to mitogen activation, which in many cases is totally eliminated. These data suggest a mechanism by which the virus causes a transient immunosuppression, subvert the immune systems, and spreads. These results have important implications for our understanding of early events in the development of a robust immune response against FMDV.

Immune response of calves to foot-and-mouth disease virus vaccine emulsified with oil adjuvant. Strategies of vaccination

Vaccine ◽  
1995 ◽  
Vol 13 (10) ◽  
pp. 909-914 ◽  
Author(s):  
E.J.A. Späth ◽  
E. Smitsaart ◽  
A.P.E. Casaro ◽  
N. Fondevila ◽  
F. Fernández ◽  
...  
Keyword(s):  
Immune Response ◽  
Disease Virus ◽  
Virus Vaccine ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Mouth Disease Virus ◽  
Foot And Mouth
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