Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fup/fumic) for refined prediction of phase I mediated metabolic hepatic clearance

2011 ◽  
Vol 63 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Sujal V. Deshmukh ◽  
Andreas Harsch
Keyword(s):  
Phase I ◽  
Direct Determination ◽  
Hepatic Clearance ◽  
Unbound Fraction

A method for the direct determination of the rate constants for radical-radical interactions in the gas phase I. The technique of investigation

1957 ◽  
Vol 243 (1232) ◽  
pp. 119-129 ◽  
Keyword(s):  
Time Delay ◽  
Phase I ◽  
Gas Phase ◽  
Direct Determination ◽  
Pressure Change ◽  
Gas Phase Reactions ◽  
Temperature Changes ◽  
Pressure Changes ◽  
Better Than

A method of following the non-stationary state in simple photochemically initiated gas-phase reactions is described. Measurements are recorded by observing the pressure change occurring in the gas resulting from the adiabatic temperature changes caused by reaction. The pressure changes are observed by means of a sensitive diaphragm type manometer, whose sensitivity in detection is better than 10 -4 mm Hg and whose time delay in response is less than 10 -3 s.

The Direct Determination of I131 in Heterogeneous Fecal Specimens

1961 ◽  
Vol 41 (4) ◽  
pp. 380-384 ◽  
Author(s):  
Arthur F. Dratz ◽  
James C. Coberly
Keyword(s):  
Direct Determination

A New Method for Direct Determination of the Recoilless Fraction with Application to Magnetic Nanoparticles

2002 ◽  
Vol 721 ◽  
Author(s):  
Monica Sorescu
Keyword(s):  
Room Temperature ◽  
Average Particle Size ◽  
Direct Determination ◽  
Average Particle ◽  
Lattice Method ◽  
Recoilless Fraction ◽  
Single Room ◽  
Magnetite Particles ◽  
Physical Mixtures

AbstractWe propose a two-lattice method for direct determination of the recoilless fraction using a single room-temperature transmission Mössbauer measurement. The method is first demonstrated for the case of iron and metallic glass two-foil system and is next generalized for the case of physical mixtures of two powders. We further apply this method to determine the recoilless fraction of hematite and magnetite particles. Finally, we provide direct measurement of the recoilless fraction in nanohematite and nanomagnetite with an average particle size of 19 nm.

Polarographic Determination of 6-β-D-Glucopyranosyloxy-7-hydroxycoumarin

1996 ◽  
Vol 61 (3) ◽  
pp. 333-341
Author(s):  
Jiří Barek ◽  
Roman Hrnčíř ◽  
Josino C. Moreira ◽  
Jiří Zima
Keyword(s):  
Natural Compound ◽  
Mercury Electrode ◽  
Direct Determination ◽  
Differential Pulse ◽  
Differential Pulse Polarography ◽  
Whitening Agent ◽  
Polarographic Behaviour ◽  
Pulse Polarography ◽  
Dropping Mercury Electrode

The polarographic behaviour was studied for 6-β-D-glucopyranosyloxy-7-hydroxycoumarin, a natural compound serving as an optical whitening agent. The substance can be quantitated by tast polarography, differential pulse polarography using a conventional dropping mercury electrode, and differential pulse polarography using a static mercury drop electrode over the regions of 20-1 000, 2-1 000, and 0.2-1 000 μmol l-1, respectively. The methods developed for the quantitation of the compound were applied to its direct determination in a raw product.

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