Comparative profiling of the resistance of different genotypes of mannose-binding lectin to Mycoplasma pneumoniae infection in Chinese Merino sheep based on high-throughput sequencing technology

2021 ◽  
pp. 110183
Author(s):  
Mengting Zhu ◽  
Ying Nan ◽  
Mengting Zhai ◽  
Mingyuan Wang ◽  
Yanyan Shao ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Mannose Binding Lectin ◽  
Sequencing Technology ◽  
Merino Sheep ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Mycoplasma Pneumoniae Infection

scholarly journals High-throughput genotyping of mannose-binding lectin variants using high-resolution DNA-melting analysis

2010 ◽  
Vol 31 (4) ◽  
pp. E1286-E1293 ◽  
Author(s):  
Rolf H.A.M. Vossen ◽  
Martine van Duijn ◽  
Mohamed R. Daha ◽  
Johan T. den Dunnen ◽  
Anja Roos
Keyword(s):  
High Resolution ◽  
High Throughput ◽  
Mannose Binding Lectin ◽  
Dna Melting ◽  
Mannose Binding ◽  
Melting Analysis ◽  
Binding Lectin

RECURRENT STREPTOCOCCAL INFECTION IN A CHILD WITH A CONGENITAL DEFICIENCY OF MANNOSE-BINDING LECTIN

2020 ◽  
Vol 99 (6) ◽  
pp. 266-270
Author(s):  
A.S. Levina ◽  
◽  
E.N. Suspitsin ◽  
N.V. Skripchenko ◽  
D.L. Strekalov ◽  
...  
Keyword(s):  
High Throughput Sequencing ◽  
Streptococcal Infection ◽  
Group A Streptococcus ◽  
Mannose Binding Lectin ◽  
Homozygous Mutation ◽  
Congenital Deficiency ◽  
Mannose Binding ◽  
Group A ◽  
Binding Lectin

Objective of the research: to present the clinical and laboratory features of a child with a congenital deficiency of mannose-binding lectin (MBL). Materials and methods: DNA samples of 112 children suffering from frequent infectious diseases were analyzed by high-throughput sequencing (Illumina) using a panel including 338 genes associated with the development of primary immunodeficiencies. A search for pathogenic alleles of MBL2 was performed. A homozygous mutation in the MBL2 gene was detected in one of 112 examined patients, heterozygous carriage of the pathogenic MBL2 allele in two children. The story of a child with a homozygous defect of this gene is presented. The role of MSL deficiency in the development of a recurrent course of a nasopharyngeal infection caused by group A streptococcus, the formation of a chronic disease of the tonsils and adenoids is demonstrated.

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