The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009

2011 ◽  
Vol 150 (3-4) ◽  
pp. 257-269 ◽  
Author(s):  
Zhi Zhou ◽  
Jianqiang Ni ◽  
Zhen Cao ◽  
Xue Han ◽  
Yingju Xia ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic

scholarly journals The Genomic and Pathogenic Characteristics of the Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Isolate WUH2

ISRN Virology ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-15 ◽  
Author(s):  
Bin Li ◽  
Liurong Fang ◽  
Suyan Liu ◽  
Yunbo Jiang ◽  
Huanchun Chen ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Experimental Infection ◽  
Virus Isolate ◽  
Genomic Sequence ◽  
Point Mutations ◽  
Genomic Diversity ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Insight Into ◽  
Highly Pathogenic Prrsv

To fully understand the extent of genetic diversity and pathogenesis of the highly pathogenic PRRSV found in China, we determined the genomic sequence of PRRSV WUH2; the pathogenicity of WUH2 was compared to the classical PRRSV isolate CH-1a. Our results showed that the WUH2 genome had a discontinuous deletion of 30 aa in Nsp2, a 1 nucleotide deletion located in both the 5′ and 3′ UTRs, and point mutations within GP5. Experimental infection demonstrated that PRRSV WUH2 reproduced the phenotype and symptoms of porcine high fever syndrome. Importantly, we found that there were differences in viral burden in the serum and tissues when comparing infections of the pathogenic isolate WUH2 to those of the classical isolate CH-1a. These data provide insight into the genomic diversity and altered pathogenicity of Chinese PRRSV isolates and help elucidate the evolution and potential pathogenic mechanisms of PRRSV.

scholarly journals Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus Infection Induced Apoptosis and Autophagy in Thymi of Infected Piglets

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128292 ◽  
Author(s):  
Gang Wang ◽  
Ying Yu ◽  
Yabin Tu ◽  
Jie Tong ◽  
Yonggang Liu ◽  
...  
Keyword(s):  
Virus Infection ◽  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Induced Apoptosis

scholarly journals Genetic Diversity of the ORF5 Gene of Porcine Reproductive and Respiratory Syndrome Virus Isolates in Southwest China from 2007 to 2009

PLoS ONE ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. e33756 ◽  
Author(s):  
Gefen Yin ◽  
Libo Gao ◽  
Xianghua Shu ◽  
Guishu Yang ◽  
Shuhao Guo ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Southwest China ◽  
Respiratory Syndrome Virus ◽  
Orf5 Gene ◽  
Virus Isolates

scholarly journals Research Progress of Porcine Reproductive and Respiratory Syndrome

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Xueqi Liao
Keyword(s):  
Genetic Diversity ◽  
Genetic Variation ◽  
Immune Suppression ◽  
Persistent Infection ◽  
The Body ◽  
Research Progress ◽  
Respiratory Syndrome Virus ◽  
Control Technology ◽  
Reproductive Disorder ◽  
And Control

Porcine Reproductive and Respiratory Syndrome (PRRS) is caused by Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), which is characterized by sow reproductive disorder and piglet respiratory syndrome. The complex pathogenesis of PPRS includes antibody-dependent enhancement, immune suppression and persistent infection in the body and viral genetic diversity. In order to have a better understanding of the occurrence and prevalence of porcine reproductive and respiratory syndrome in China. The review of PRRS etiology, epidemiology, pathogenesis, genetic variation, diagnosis and control technology and other aspects of the progress were carried out.

Immunogenicity of the highly pathogenic porcine reproductive and respiratory syndrome virus GP5 protein encoded by a synthetic ORF5 gene

Vaccine ◽  
2009 ◽  
Vol 27 (13) ◽  
pp. 1957-1963 ◽  
Author(s):  
Bin Li ◽  
Shaobo Xiao ◽  
Yanwei Wang ◽  
Shanshan Xu ◽  
Yunbo Jiang ◽  
...  
Keyword(s):  
Respiratory Syndrome Virus ◽  
Highly Pathogenic ◽  
Orf5 Gene

A novel HRM assay for differentiating classical strains and highly pathogenic strains of type 2 porcine reproductive and respiratory syndrome virus

2018 ◽  
Vol 39 ◽  
pp. 25-32 ◽  
Author(s):  
Junying Sun ◽  
Gali Bingga ◽  
Zhicheng Liu ◽  
Chunhong Zhang ◽  
Haiyan Shen ◽  
...  
Keyword(s):  
Respiratory Syndrome Virus ◽  
Highly Pathogenic
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