Efficacy of milbemycin oxime in combination with spinosad in the treatment of larval and immature adult stages of Ancylostoma caninum and Toxocara canis in experimentally infected dogs

2014 ◽  
Vol 205 (1-2) ◽  
pp. 134-139 ◽  
Author(s):  
Dwight D. Bowman ◽  
Craig R. Reinemeyer ◽  
Scott Wiseman ◽  
Daniel E. Snyder
Keyword(s):  
Toxocara Canis ◽  
Ancylostoma Caninum ◽  
Milbemycin Oxime

scholarly journals Efficacy of Emodepside plus Toltrazuril (Procox® Oral Suspension for Dogs) against Toxocara canis, Uncinaria stenocephala and Ancylostoma caninum in Dogs

2011 ◽  
Vol 109 (S1) ◽  
pp. 1-8 ◽  
Author(s):  
Annette Schimmel ◽  
Iris Schroeder ◽  
Gertraut Altreuther ◽  
Terry Settje ◽  
Samuel Charles ◽  
...  
Keyword(s):  
Toxocara Canis ◽  
Oral Suspension ◽  
Ancylostoma Caninum

scholarly journals Riesgo potencial de parásitos zoonóticos presentes en heces caninas en Puerto Escondido, Oaxaca

2014 ◽  
Vol 56 (6) ◽  
pp. 625 ◽  
Author(s):  
León Vélez-Hernández ◽  
Karen Lizbeth Reyes-Barrera ◽  
Daniela Rojas-Almaráz ◽  
Mónica Alicia Calderón-Oropeza ◽  
Julieta Karina Cruz-Vázquez ◽  
...  
Keyword(s):  
Toxocara Canis ◽  
Ancylostoma Caninum ◽  
Dipylidium Caninum

Objetivo. Estimar la prevalencia de parásitos potencialmente zoonóticos en heces caninas de Puerto Escondido. Material y métodos. La ciudad se dividió en diez zonas de estudio y éstas se categorizaron en hábitats natural, urbano y suburbano. Se colectaron muestras fecales caninas del piso. Se recuperaron los parásitos por medio de técnicas coproparasitológicas de flotación y frotis directo para su observación microscópica y posterior identificación. Se estimó la prevalencia parasitaria en las heces caninas. Resultados. Todas las zonas presentaron fecalismo canino. La prevalencia parasitaria fue de 73.33%. Los parásitos con mayor prevalencia fueron Toxocara canis (47.78%), Ancylostoma caninum (17.88%) y Dipylidium caninum (13.89%). Conclusión. El fecalismo canino proviene de perros errantes y con dueño. Del total de parásitos encontrados, 66.66% son zoonóticos. Los factores que favorecen la problemática son el hábitat suburbano, el manejo indeseable de la basura y la tenencia irresponsable de los cánidos.

scholarly journals Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) against natural intestinal nematode infections in dogs presented as veterinary patients in Europe

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Brad Hayes ◽  
Scott Wiseman ◽  
Daniel E. Snyder
Keyword(s):  
Field Study ◽  
Drug Product ◽  
Geometric Mean ◽  
Animal Health ◽  
Good Clinical Practice ◽  
Toxocara Canis ◽  
New Combination ◽  
Combination Drug ◽  
Milbemycin Oxime ◽  
Faecal Egg Counts

Abstract Background A randomised, blinded, positive controlled, multicentre, Good Clinical Practice-compliant, pivotal field study was conducted to evaluate the effectiveness and safety of a new combination of lotilaner + milbemycin oxime tablets (Credelio® Plus; Elanco Animal Health) administered orally to client-owned dogs naturally infected with intestinal nematodes. Methods Client-owned dogs presenting to veterinary clinics from households in France, Hungary and Germany were screened for intestinal nematodes. Dogs with an initial positive faecal egg count that was subsequently confirmed with a follow-up faecal examination to demonstrate the presence of naturally occurring mixed or mono-infections with Toxocara canis, Toxascaris leonina, Trichuris vulpis or Ancylostoma caninum were enrolled on Day 0 into the study. Households were randomised in an approximately 2:1 ratio to receive either an investigational product (IP; Credelio Plus tablets) or control product (CP; Nexgard Spectra® tablets) as treatment. Dogs were administered the IP (n = 278) or CP (n = 117) once on Day 0 at a dose rate of 0.75–1.56 mg/kg bodyweight milbemycin oxime and 20.0–41.5 mg/kg bodyweight lotilaner (IP) or as recommended (CP). Effectiveness of the IP and CP treatments was based on the post-treatment reduction in geometric mean faecal egg counts on Day 8 (range Day 7–10) after treatment as compared to their pre-treatment nematode faecal egg counts. Results Geometric mean (GM) faecal egg counts for T. canis, A caninum and T. vulpis were reduced by ≥ 97.2% in the Credelio Plus group and  by ≥ 95.3% in the afoxolaner + milbemycin oxime group. There were insufficient data to calculate a percentage reduction in GM faecal egg counts between Day 0 and Day 8 for T. leonina due to low prevalence. Credelio Plus was well tolerated in this field study. Of the 355 total doses administered, 82.3% were accepted free choice in the IP group compared to 80.8% in the CP group. Conclusions This study demonstrated effectiveness (≥ 97.2% reduction), safety and tablet acceptance of a combination of milbemycin oxime and lotilaner (Credelio Plus) administered orally to dogs with natural intestinal infections of T. canis, A. caninum and T. vulpis.

scholarly journals Effectiveness of Credelio® Plus, a novel chewable tablet containing milbemycin oxime and lotilaner for the treatment of larval and immature adult stages of Toxocara canis in experimentally infected dogs

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Lisa M. Young ◽  
Scott Wiseman ◽  
Elizabeth Crawley ◽  
Dwight D. Bowman ◽  
Craig R. Reinemeyer ◽  
...  
Keyword(s):  
Geometric Mean ◽  
Toxocara Canis ◽  
Time Frame ◽  
Immature Stage ◽  
Chewable Tablet ◽  
Combination Tablet ◽  
Milbemycin Oxime ◽  
Treatment Groups ◽  
Intestinal Nematode ◽  
Respective Treatment

Abstract Background The ascarid, Toxocara canis, is a common and important zoonotic intestinal nematode parasite that infects dogs globally. An effective treatment that kills any pre-patent stages of immature T. canis could additionally reduce or eliminate the development of patent infections that can result in clinical disease in infected dogs and would further reduce environmental contamination of eggs. Two randomized, blinded, GCP-compliant, pivotal laboratory dose confirmation studies were conducted to assess the effectiveness and safety of a new novel combination of lotilaner and milbemycin oxime tablets (Credelio Plus) administered orally to dogs that were experimentally infected with immature (L4 or immature adult [L5]) stages of T. canis. Methods The commercial tablet formulation of Credelio Plus® was administered in a time frame relative to inoculation with infective eggs. This allowed for effectiveness to be assessed against each specific immature stage of T. canis. In each study, dogs were randomized and allocated to one of four treatment groups. Each treatment group contained ten dogs that had been experimentally inoculated on Day 0 with infective T. canis eggs and then were dosed once on Day 14 or Day 24 using either placebo tablets or Credelio Plus tablets (IP) to provide minimum dosages of 0.75 mg/kg of milbemycin oxime and 20 mg/kg of lotilaner. All dogs were necropsied 5 or 6 days after their respective treatment. At necropsy, all nematodes recovered from the gastrointestinal tract were counted by species and stage. Results In both dose confirmation studies using geometric mean worm counts, effectiveness of Credelio Plus was ≥ 98.6% and ≥ 96.8% against L4 larval stage T. canis and immature adult [L5] T. canis in both studies, respectively. Conclusions These studies demonstrated that the Credelio Plus combination tablet administered orally to dogs was highly efficacious against experimental infections with L4 and immature adult [L5] stages of T. canis.

scholarly journals PREVALENCIA Y FACTORES DE RIESGO ASOCIADOS CON LA INFECCIÓN DE TOXOCARA CANIS Y ANCYLOSTOMA CANINUM EN CANES DE COMPAÑÍA

The Biologist ◽  
2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Julio C. Castillo-Cuenca ◽  
José Iannacone ◽  
Rigoberto Fimia-Duarte ◽  
Omelio Cepero-Rodríguez ◽  
Alcides Morales-Morales
Keyword(s):  
Toxocara Canis ◽  
Ancylostoma Caninum ◽  
Factores De Riesgo

scholarly journals PARÁSITOS GASTROINTESTINALES EN PERROS CALLEJEROS DEL CENTRO DE ZOONOSIS DE BOGOTÁ D.C., COLOMBIA

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Luz Dary Solarte-Paredes ◽  
Rubiela Castañeda-Salazar ◽  
Adriana del Pilar Pulido-Villamarín
Keyword(s):  
Toxocara Canis ◽  
Ancylostoma Caninum ◽  
Para Determinar

Para determinar la prevalencia de Toxocara canis Werner, 1782 , Ancylostoma caninum Ercolani, 1859 e Isospora canis Meneséri, 1959 en perros callejeros del centro de zoonosis de Bogotá, Colombia, se obtuvieron un total de 70 muestras de materia fecal, colectadas del suelo de cada encierro donde se encontraban los caninos capturados en 11 localidades; un “pool” correspondió a una muestra por localidad, se realizaron tres muestreos seriados y cada muestra se analizó macroscópica y microscópicamente mediante técnicas coprológicas cualitativas y cuantitativas para determinar la presencia de huevos de helmintos u ooquistes. Se encontró una positividad del 88,6% (n= 62) en el total las muestras, donde el 52,9% correspondió a A. caninum, el 7,1% a T. canis, el 24,3% a infecciones mixtas por A. caninum y T. canis, el 1,4% a A. caninum, T. canis e I. canis y el 2,9% a infecciones por A. caninum e I. canis. Las localidades que presentaron el 100% de positividad fueron Usme, Bosa, Chapinero, Ciudad Bolívar y Kennedy. En las otras localidades muestreadas los porcentajes se presentaron entre el 70-80%. Los perros callejeros provenientes de las localidades muestreadas presentaron mono y/o poliparasitismo, dos de los cuales implican un potencial zoonótico (A. caninum y T. canis), lo que representa riesgo de contaminación tanto humana como animal por la eliminación al ambiente de altas cargas parasitarias.

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