Atraumatic first trimester rupture of an unscarred bicornuate uterus with previous term pregnancy

2021 ◽  
Vol 25 ◽  
pp. 101127
Author(s):  
Vicky Yu ◽  
Jerry A. Burns ◽  
Rodger Langster
Keyword(s):  
First Trimester ◽  
Term Pregnancy ◽  
Bicornuate Uterus

scholarly journals Involvement of nephrin in human placental trophoblast syncytialization

Reproduction ◽  
2015 ◽  
Vol 149 (4) ◽  
pp. 339-346 ◽  
Author(s):  
Yue Li ◽  
Ru Zheng ◽  
Rui Wang ◽  
Xiaoyin Lu ◽  
Cheng Zhu ◽  
...  
Keyword(s):  
Cell Fusion ◽  
Connexin 43 ◽  
Transmembrane Protein ◽  
First Trimester ◽  
Trophoblast Cell ◽  
Term Pregnancy ◽  
Fusion Model ◽  
Placental Development ◽  
Functional Conservation ◽  
Ig Superfamily

The placenta has numerous functions, such as transporting oxygen and nutrients and building the immune tolerance of the fetus. Cell fusion is an essential process for placental development and maturation. In human placental development, mononucleated cytotrophoblast (CTB) cells can fuse to form a multinucleated syncytiotrophoblast (STB), which is the outermost layer of the placenta. Nephrin is a transmembrane protein that belongs to the Ig superfamily. Previous studies have shown that nephrin contributes to the fusion of myoblasts into myotubes in zebrafish and mice, presenting a functional conservation with its Drosophila ortholog sticks and stones. However, whether nephrin is involved in trophoblast syncytialization remains unclear. In this study, we report that nephrin was localized predominantly in the CTB cells and STB of human placenta villi from first trimester to term pregnancy. Using a spontaneous fusion model of primary CTB cells, the expression of nephrin was found to be increased during trophoblast cell fusion. Moreover, the spontaneous syncytialization and the expression of syncytin 2, connexin 43, and human chorionic gonadotropin beta were significantly inhibited by nephrin-specific siRNAs. The above results demonstrate that nephrin plays an important role in trophoblast syncytialization.

scholarly journals First-trimester rupture of a gravid bicornuate uterus after prior vaginal deliveries, simulating a ruptured ectopic pregnancy: a case report

2020 ◽  
Vol 2020 (10) ◽  
Author(s):  
Joel Noutakdie Tochie ◽  
Landry Wakheu Tcheunkam ◽  
Collince Tchakounté ◽  
Nkengafac Nyiawung Fobellah ◽  
Samuel Nambile Cumber
Keyword(s):  
Ectopic Pregnancy ◽  
Iliac Fossa ◽  
First Trimester ◽  
Sudden Onset ◽  
Left Iliac Fossa ◽  
Bicornuate Uterus ◽  
Vaginal Deliveries ◽  
Future Fertility ◽  
Operative Findings ◽  
High Index Of Suspicion

Abstract The first-trimester rupture of a bicornuate uterus (BU) is a rare obstetrical emergency, especially following previous normal vaginal deliveries where it is often misdiagnosed. A 24-year-old G3P2002 woman presented at 11 weeks of gestation with sudden onset of severe left iliac fossa pain without other symptoms. On examination, she was fully conscious and hemodynamically unstable with signs of peritoneal irritation, a distended pouch of Douglas and a slightly enlarged uterus and a tender left adnexal mass. The diagnosis of a ruptured ectopic pregnancy was made and a laparotomy was done. Intra-operative findings were hemoperitoneum, a left ruptured BU and a dead fetus. Surgical management entailed hysterorrarphy, left salpingectomy and conservation of both ovaries. Her postoperative course was uneventful and future fertility was preserved. We recommend a high index of suspicion of ruptured BU as a differential diagnosis of acute abdomen in the first trimester in women with previous term vaginal deliveries.

Laparoscopic metroplasty for bicornuate uterus – A case report

2021 ◽  
Vol 8 (2) ◽  
pp. 279-281
Author(s):  
Lakshmi Subburaj ◽  
K Rajkumar
Keyword(s):  
Case Report ◽  
First Trimester ◽  
Mullerian Duct ◽  
Spontaneous Abortions ◽  
Bicornuate Uterus ◽  
Müllerian Duct ◽  
Recurrent Spontaneous Abortions ◽  
Fertility Status ◽  
Müllerian Duct Anomalies ◽  
Müllerian Duct Anomaly

Bicornuate uterus is a type of mullerian duct anomaly which is responsible for recurrent spontaneous first trimester abortions. They are best managed surgically using Strassman’s metroplasty. We present a case of recurrent spontaneous abortions which was diagnosed as bicornuate uterus. We performed a laparoscopic metroplasty which was successful and did not encounter complications like adhesions or hemorrhage. The advantages of laparoscopic metroplasty outweighs the challenges in restoring fertility status to women with mullerian duct anomalies.

OGP 6103 First trimester of pregnancy and bicornuate uterus

1997 ◽  
Vol 23 ◽  
pp. S123
Author(s):  
Eduardo Valtorta ◽  
Miguel Montorfano ◽  
Sergio Ricci
Keyword(s):  
First Trimester ◽  
Bicornuate Uterus ◽  
First Trimester Of Pregnancy

The Impact of First Trimester TSH Level on Fetal Growth and Post-Term Pregnancy

2021 ◽  
pp. 1-8
Author(s):  
Umit Yasemin Sert ◽  
Hatice Kansu Celik ◽  
Burcu Kısa Karakaya ◽  
Ali Turhan Caglar ◽  
Gokcen Erdogan ◽  
...  
Keyword(s):  
Fetal Growth ◽  
First Trimester ◽  
Term Pregnancy ◽  
The Impact ◽  
Post Term Pregnancy

scholarly journals Three types of HLA-G+ extravillous trophoblasts that have distinct immune regulatory properties

2020 ◽  
Vol 117 (27) ◽  
pp. 15772-15777 ◽  
Author(s):  
Henrieta Papuchova ◽  
Sarika Kshirsagar ◽  
Lily Xu ◽  
Hannah A. Bougleux Gomes ◽  
Qin Li ◽  
...  
Keyword(s):  
Pregnancy Complications ◽  
Inflammatory Responses ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
First Trimester ◽  
Term Pregnancy ◽  
Placental Development ◽  
Underlying Mechanisms ◽  
And Function ◽  
Extravillous Trophoblasts

During pregnancy, invading HLA-G+ extravillous trophoblasts (EVT) play a key role in placental development, uterine spiral artery remodeling, and prevention of detrimental maternal immune responses to placental and fetal antigens. Failures of these processes are suggested to play a role in the development of pregnancy complications, but very little is known about the underlying mechanisms. Here we present validated methods to purify and culture primary HLA-G+ EVT from the placental disk and chorionic membrane from healthy term pregnancy. Characterization of HLA-G+ EVT from term pregnancy compared to first trimester revealed their unique phenotypes, gene expression profiles, and differing capacities to increase regulatory T cells (Treg) during coculture assays, features that cannot be captured by using surrogate cell lines or animal models. Furthermore, clinical variables including gestational age and fetal sex significantly influenced EVT biology and function. These methods and approaches form a solid basis for further investigation of the role of HLA-G+ EVT in the development of detrimental placental inflammatory responses associated with pregnancy complications, including spontaneous preterm delivery and preeclampsia.

Plasma concentration of atrial natriuretic peptide and brain natriuretic peptide during normal human pregnancy and the postpartum period

1994 ◽  
Vol 140 (3) ◽  
pp. 393-397 ◽  
Author(s):  
T Yoshimura ◽  
M Yoshimura ◽  
H Yasue ◽  
M Ito ◽  
H Okamura ◽  
...  
Keyword(s):  
Plasma Level ◽  
Natriuretic Peptide ◽  
Blood Volume ◽  
Postpartum Period ◽  
Plasma Levels ◽  
First Trimester ◽  
Term Pregnancy ◽  
Assay Sensitivity ◽  
Human Pregnancy ◽  
Normal Human

Abstract Increases in blood volume are observed during normal gestation and these are reversed shortly after delivery. Although both atrial (A-type) natriuretic peptide (ANP) and brain (B-type) natriuretic peptide (BNP) have been described, the role of these peptides in pregnancy and the postpartum period are unclear. This study was designed to examine the effects of pregnancy, labour and delivery on plasma levels of ANP and BNP. Plasma levels of ANP and BNP were determined during normal pregnancy, 30 min after separation of the placenta (immediately postpartum) and between 5 and 72 h postpartum (late postpartum; puerperium). Since the assay sensitivity was 20 pg/ml plasma (for both ANP and BNP), values less than this were assigned a value of 20 pg/ml to calculate means. Plasma levels of ANP and BNP were significantly higher at term pregnancy than during the first trimester (ANP increased from 20 ± 0·2 to 57 ± 10 pg/ml (s.e.m.), P<0·001; BNP increased from 25 ± 2 to 49 ± 9 pg/ml, P<0·01). The plasma level of ANP then rose to 157 ± 38 pg/ml 30 min after separation of the placenta, being significantly (P<0·01) higher than that seen at term pregnancy. It declined significantly (P<0·001) to 32 ± 3 pg/ml in the late postpartum period. In contrast, the plasma level of BNP 30 min after separation of the placenta was 80 ± 25 pg/ml, and increased to 116 ± 17 pg/ml in the late postpartum period, significantly (P<0·01) higher than the level at term pregnancy. We conclude that ANP and BNP may play a role in controlling blood volume during normal human pregnancy at term and during transition to the postpartum period. Changes in ANP immediately postpartum and BNP in the later postpartum period appear to be differentially regulated. Journal of Endocrinology (1994) 140, 393–397

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