Hydroxyl free radical reactivity toward aqueous chlorinated phenols

Abstract:: Minisci-type reactions have become widely known as reactions that involve the addition of carbon-centered radicals to basic heteroarenes followed by formal hydrogen atom loss. While the originally developed protocols for radical generation remain in active use today, in recent years by a new array of radical generation strategies allow use of a wider variety of radical precursors that often operate under milder and more benign conditions. New transformations based on free radical reactivity are now available to a synthetic chemist looking to utilize a Minisci-type reaction. Radical-generation methods based on photoredox catalysis and electrochemistry, which utilize thermal cleavage or the in situ generation of reactive radical precursors, have become popular approaches. Our review will cover the remarkably literature that has appeared on this topic in recent 5 years, from 2015-01 to 2020-01, in an attempt to provide guidance to the synthetic chemist, on both the challenges that have been overcome and applications in organic synthesis.

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Study of the mechanisms of hydrogen peroxide and hydroxyl free radical-induced cellular injury and calcium overload in cardiac myocytes

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)52251-1 ◽

1991 ◽

Vol 266 (4) ◽

pp. 2354-2361

Author(s):

R A Josephson ◽

H S Silverman ◽

E G Lakatta ◽

M D Stern ◽

J L Zweier

Keyword(s):

Hydrogen Peroxide ◽

Free Radical ◽

Cardiac Myocytes ◽

Calcium Overload ◽

Cellular Injury ◽

Hydroxyl Free Radical

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Note: A Comparative Study on the in Vitro Antiradical Activity and Hydroxyl Free Radical Scavenging Activity in Aged Red Wines

Food Science and Technology International ◽

10.1177/1082013203040080 ◽

2003 ◽

Vol 9 (6) ◽

pp. 383-387 ◽

Cited By ~ 19

Author(s):

P. Kefalas ◽

S. Kallithraka ◽

I. Parejo ◽

D. P. Makris

Keyword(s):

Free Radical ◽

Antiradical Activity ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Free Radical Scavenging ◽

Free Radical Scavenging Activity ◽

Scavenging Activity ◽

Red Wines ◽

Hydroxyl Free Radical ◽

Important Relationship

The antiradical and hydroxyl free radical scavenging activities were estimated in twenty-five, aged red wines from different areas in Greece. The antiradical activity (AAR) was determined by means of the wellknown DPPH• method, and its values ranged from 24.7 to 125.1. A novel, chemiluminescence-based, highly sensitive assay was applied for determination of the hydroxyl free radical scavenging activity (SAHFR), which varied from 1.62 to 12.22 mM quercetin equivalents. The values from the two assays correlated very well (r2 =0.8542, P<0.001), which confirmed an important relationship between SAHFR and AAR. This tendency in aged red wines, which may be significant in evaluating the antioxidant behaviour of red wine polyphenols, is discussed on the basis of previous research and relevant data.

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Antioxidant Capacities of Water-Soluble Substances Extracted from JinHua Ham

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.675-677.1654 ◽

2014 ◽

Vol 675-677 ◽

pp. 1654-1657

Author(s):

Xiao Li Zhou ◽

Xu Chen ◽

Ting Feng Hao ◽

Yi Ming Zhou ◽

Ying Xiao

Keyword(s):

Antioxidant Activity ◽

Free Radical ◽

Antioxidant Capacity ◽

Mass Fraction ◽

Water Soluble ◽

Oxidation Capacity ◽

Hydroxyl Free Radical ◽

Antioxidant Capacities ◽

Dpph Scavenging ◽

Jinhua Ham

This study was designed to evaluate the antioxidant activity of samples extracted from Jinhua ham by using such chemical assays as DPPH, scavenging hydroxyl free radical and ABTS. The results demonstrate that antioxidant capacity of the extracted sample is lower than oxidation capacity of Vc. The IC50 spot of samples ranges between 0.6 % and 2.5 % (mass fraction of solute).

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