Completion Corpus Callosotomy with Stereotactic Radiosurgery for Drug-Resistant, Intractable Epilepsy

2020 ◽  
Vol 143 ◽  
pp. 440-444
Author(s):  
Sean Sachdev ◽  
Timothy L. Sita ◽  
Nathan A. Shlobin ◽  
Mahesh Gopalakrishnan ◽  
Roy Sucholeiki ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Intractable Epilepsy ◽  
Drug Resistant ◽  
Corpus Callosotomy

Gamma knife stereotactic radiosurgery for drug resistant or intolerant invasive prolactinomas

Pituitary ◽  
2012 ◽  
Vol 16 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Xiaomin Liu ◽  
Hideyuki Kano ◽  
Douglas Kondziolka ◽  
Kyung-Jae Park ◽  
Aditya Iyer ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Gamma Knife ◽  
Drug Resistant ◽  
Gamma Knife Stereotactic Radiosurgery

scholarly journals Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis

2021 ◽  
Vol 11 (5) ◽  
pp. 638
Author(s):  
Ayataka Fujimoto ◽  
Keisuke Hatano ◽  
Toshiki Nozaki ◽  
Keishiro Sato ◽  
Hideo Enoki ◽  
...  
Keyword(s):  
Risk Factors ◽  
Computed Tomography ◽  
Risk Factor ◽  
Intractable Epilepsy ◽  
Epileptic Seizures ◽  
Computed Tomography Scan ◽  
Corpus Callosotomy ◽  
Significant Difference ◽  
Chemical Meningitis ◽  
Tomography Scan

Background: A corpus callosotomy (CC) is a procedure in which the corpus callosum, the largest collection of commissural fibers in the brain, is disconnected to treat epileptic seizures. The occurrence of chemical meningitis has been reported in association with this procedure. We hypothesized that intraventricular pneumocephalus after CC surgery represents a risk factor for postoperative chemical meningitis. The purpose of this study was to analyze the potential risk factors for postoperative chemical meningitis in patients with medically intractable epilepsy who underwent a CC. Methods: Among the patients who underwent an anterior/total CC for medically intractable epilepsy between January 2009 and March 2021, participants were comprised of those who underwent a computed tomography scan on postoperative day 0. We statistically compared the groups with (c-Group) or without chemical meningitis (nc-Group) to determine the risk factors. Results: Of the 80 patients who underwent a CC, 65 patients (25 females and 40 males) met the inclusion criteria. Their age at the time of their CC procedure was 0–57 years. The c-Group (17%) was comprised of seven females and four males (age at the time of their CC procedure, 1–43 years), and the nc-Group (83%) was comprised of 18 females and 36 males (age at the time of their CC procedure, 0–57 years). Mann–Whitney U-tests (p = 0.002) and univariate logistic regression analysis (p = 0.001) showed a significant difference in pneumocephalus between the groups. Conclusion: Postoperative pneumocephalus identified on a computed tomography scan is a risk factor for post-CC chemical meningitis.

In Reply to “Corpus Callosotomy for Drug-Resistant Schizophrenia; Novel Treatment Based on Pathophysiology”

2018 ◽  
Vol 116 ◽  
pp. 485
Author(s):  
Felix Neumaier ◽  
Mario Paterno ◽  
Serdar Alpdogan ◽  
Etienne E. Tevoufouet ◽  
Toni Schneider ◽  
...  
Keyword(s):  
Drug Resistant ◽  
Corpus Callosotomy ◽  
Novel Treatment

Stereotactic Radiosurgery for Medically Intractable Epilepsy

2009 ◽  
pp. 1035-1041 ◽  
Author(s):  
Isaac Yang ◽  
Edward F. Chang ◽  
Nicholas M. Barbaro
Keyword(s):  
Stereotactic Radiosurgery ◽  
Intractable Epilepsy

scholarly journals Continuing Burden of Refractory Epilepsy

2020 ◽  
pp. 106002802094805
Author(s):  
Marnie T. Janson ◽  
Jacquelyn L. Bainbridge
Keyword(s):  
Refractory Epilepsy ◽  
Neurological Diseases ◽  
Intractable Epilepsy ◽  
Premature Death ◽  
Additional Benefit ◽  
Drug Resistant ◽  
Psychological Consequences ◽  
Epilepsy Treatment ◽  
Patients With Epilepsy

Epilepsy is one of the most common neurological diseases, and uncontrolled seizures remain a significant problem for one-third of patients with epilepsy on drug therapy. Ongoing seizures affect the morbidity and mortality of patients with epilepsy. Premature death is up to 3 times higher in those with epilepsy than in the general population. Quality of life is affected by refractory epilepsy with physical, social, and psychological consequences. Patients may be stigmatized by society, institutions, and their own shame surrounding seizures. Questions remain on how to treat refractory epilepsy, also called drug-resistant, pharmacoresistant, or intractable epilepsy. Cenobamate, a novel antiseizure medication, may provide additional benefit for refractory epilepsy treatment.

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