Virtual Reality during Brain Mapping for Awake-Patient Brain Tumor Surgery: Proposed Tasks and Domains to Test

2021 ◽  
Author(s):  
Gennadiy A. Katsevman ◽  
Walter Greenleaf ◽  
Ricardo García-García ◽  
Maria Victoria Perea ◽  
Valentina Ladera ◽  
...  
Keyword(s):  
Virtual Reality ◽  
Brain Tumor ◽  
Brain Mapping ◽  
Tumor Surgery ◽  
Awake Patient ◽  
Brain Tumor Surgery

Methodological and Technical Issues for Integrating Functional Magnetic Resonance Imaging Data in a Neuronavigational System

Neurosurgery ◽  
2001 ◽  
Vol 49 (5) ◽  
pp. 1145-1157 ◽  
Author(s):  
Franck-Emmanuel Roux ◽  
Danielle Ibarrola ◽  
Michel Tremoulet ◽  
Yves Lazorthes ◽  
Patrice Henry ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Motor Cortex ◽  
Brain Mapping ◽  
Fmri Data ◽  
Electrode Placement ◽  
Cortical Mapping ◽  
Tumor Surgery ◽  
Motor Cortex Stimulation ◽  
Functional Magnetic Resonance ◽  
Brain Tumor Surgery

ABSTRACT OBJECTIVE The aim of this article was to analyze the technical and methodological issues resulting from the use of functional magnetic resonance image (fMRI) data in a frameless stereotactic device for brain tumor or pain surgery (chronic motor cortex stimulation). METHODS A total of 32 candidates, 26 for brain tumor surgery and six chronic motor cortex stimulation, were studied by fMRI scanning (61 procedures) and intraoperative cortical brain mapping under general anesthesia. The fMRI data obtained were analyzed with the Statistical Parametric Mapping 99 software, with an initial analysis threshold corresponding to P < 0.001. Subsequently, the fMRI data were registered in a frameless stereotactic neuronavigational device and correlated to brain mapping. RESULTS Correspondence between fMRI-activated areas and cortical mapping in primary motor areas was good in 28 patients (87%), although fMRI-activated areas were highly dependent on the choice of paradigms and analysis thresholds. Primary sensory- and secondary motor-activated areas were not correlated to cortical brain mapping. Functional mislocalization as a result of insufficient correction of the echo-planar distortion was identified in four patients (13%). Analysis thresholds (from P < 0.0001 to P < 10−12) more restrictive than the initial threshold (P < 0.001) had to be used in 25 of the 28 patients studied, so that fMRI motor data could be matched to cortical mapping spatial data. These analysis thresholds were not predictable preoperatively. Maximal tumor resection was accomplished in all patients with brain tumors. Chronic motor cortex electrode placement was successful in each patient (significant pain relief >50% on the visual analog pain scale). CONCLUSION In brain tumor surgery, fMRI data are helpful in surgical planning and guiding intraoperative brain mapping. The registration of fMRI data in anatomic slices or in the frameless stereotactic neuronavigational device, however, remained a potential source of functional mislocalization. Electrode placement for chronic motor cortex stimulation is a good indication to use fMRI data registered in a neuronavigational system and could replace somatosensory evoked potentials in detection of the central sulcus.

Detection of after-discharges during intraoperative functional brain mapping in awake brain tumor surgery using a novel high-density circular grid

2020 ◽  
Vol 131 (4) ◽  
pp. 828-835 ◽  
Author(s):  
William O. Tatum ◽  
Jake H. McKay ◽  
Karim ReFaey ◽  
Anteneh M. Feyissa ◽  
Dan Ryan ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Mapping ◽  
High Density ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
Functional Brain ◽  
Functional Brain Mapping ◽  
Circular Grid

scholarly journals An intraoperative motor tract positioning method in brain tumor surgery: technical note

2018 ◽  
Vol 129 (3) ◽  
pp. 576-582 ◽  
Author(s):  
Fumio Yamaguchi ◽  
Hirotomo Ten ◽  
Tadashi Higuchi ◽  
Tomoko Omura ◽  
Toyoyuki Kojima ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Mapping ◽  
Motor Evoked Potentials ◽  
Tumor Resection ◽  
Safety Margin ◽  
Mapping Method ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
Positioning Method ◽  
Motor Tracts

Intraoperative 3D recognition of the motor tract is indispensable to avoiding neural fiber injury in brain tumor surgery. However, precise localization of the tracts is sometimes difficult with conventional mapping methods. Thus, the authors developed a novel brain mapping method that enables the 3D recognition of the motor tract for intrinsic brain tumor surgeries. This technique was performed in 40 consecutive patients with gliomas adjacent to motor tracts that have a risk of intraoperative pyramidal tract damage. Motor tracts were electrically stimulated and identified by a handheld brain-mapping probe, the NY Tract Finder (NYTF). Sixteen-gauge plastic tubes were mounted onto the NYTF and inserted in the estimated direction of the motor tract with reference to navigational information. Only the NYTF was removed, leaving the plastic tubes in their places, immediately after muscle motor evoked potentials were recorded at the minimum stimulation current. Motor tracts were electrically identified in all cases. Three-dimensional information on the position of motor tracts was given by plastic tubes that were neurophysiologically placed. Tips of tubes showed the resection limit during tumor removal. Safe tumor resection with an arbitrary safety margin can be performed by adjusting the length of the plastic tubes. The motor tract positioning method enabled the 3D recognition of the motor tract by surgeons and provided for safe resection of tumors. Tumor resections were performed safely before damaging motor tracts, without any postoperative neurological deterioration.

Preoperative brain mapping and intraoperative monitoring in brain tumor surgery

2005 ◽  
Vol 1278 ◽  
pp. 113-116
Author(s):  
T. Miyagishima ◽  
A. Takahashi ◽  
S. Ishiuchi ◽  
M. Hirato ◽  
N. Saito
Keyword(s):  
Brain Tumor ◽  
Brain Mapping ◽  
Intraoperative Monitoring ◽  
Tumor Surgery ◽  
Brain Tumor Surgery

scholarly journals Pre- and Intraoperative Functional Brain Mapping and Monitoring for Brain Tumor Surgery

2014 ◽  
Vol 23 (4) ◽  
pp. 296-305
Author(s):  
Kyousuke Kamada ◽  
Satoshi Hiroshima ◽  
Hiroshi Ogawa ◽  
Naoto Kunii ◽  
Kensuke Kawai ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Brain Mapping ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
Functional Brain ◽  
Functional Brain Mapping

Machine Learning Algorithm to Predict Early Complications after Brain Tumor Surgery

2018 ◽  
Author(s):  
C.H.B. van Niftrik ◽  
F. van der Wouden ◽  
V. Staartjes ◽  
J. Fierstra ◽  
M. Stienen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Brain Tumor ◽  
Learning Algorithm ◽  
Machine Learning Algorithm ◽  
Tumor Surgery ◽  
Early Complications ◽  
Brain Tumor Surgery

Role of Perioperative Factor XIII in Intracerebral Hemorrhage after Brain Tumor Surgery: A Prospective Study

2019 ◽  
Author(s):  
Estela Val Jordan ◽  
Agustín Nebra Puertas ◽  
Juan Casado Pellejero ◽  
Maria Dolores Vicente Gordo ◽  
Concepción Revilla López ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Intracerebral Hemorrhage ◽  
Prospective Study ◽  
Factor Xiii ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
A Prospective Study

scholarly journals MS-1 Surgical strategy for brain tumor based on molecular and functional connectomics profiles

2020 ◽  
Vol 2 (Supplement_3) ◽  
pp. ii2-ii2
Author(s):  
Tatsuya Abe
Keyword(s):  
Overall Survival ◽  
Brain Tumor ◽  
Standard Procedure ◽  
Awake Craniotomy ◽  
Surgical Strategy ◽  
Neurological Deficits ◽  
Cortical Mapping ◽  
Photodynamic Diagnosis ◽  
Tumor Surgery ◽  
Brain Tumor Surgery

Abstract It is reported that the development of new perioperative motor deficits was associated with decreased overall survival despite similar extent of resection and adjuvant therapy. The maximum safe resection without any neurological deficits is required to improve overall survival in patients with brain tumor. Surgery is performed with various modalities, such as neuro-monitoring, photodynamic diagnosis, neuro-navigation, awake craniotomy, intraoperative MRI, and so on. Above all, awake craniotomy technique is now the standard procedure to achieve the maximum safe resection in patients with brain tumor. It is well known that before any treatment, gliomas generate globally (and not only focally) altered functional connectomics profiles, with various patterns of neural reorganization allowing different levels of cognitive compensation. Therefore, perioperative cortical mapping and elucidation of functional network, neuroplasticity and reorganization are important for brain tumor surgery. On the other hand, recent studies have proposed several gene signatures as biomarkers for different grades of gliomas from various perspectives. Then, we aimed to identify these biomarkers in pre-operative and/or intra-operative periods, using liquid biopsy, immunostaining and various PCR methods including rapid genotyping assay. In this presentation, we would like to demonstrate our surgical strategy based on molecular and functional connectomics profiles.

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