Unique Impacts of Methionine Oxidation, Tryptophan Oxidation, and Asparagine Deamidation on Antibody Stability and Aggregation

2020 ◽  
Vol 109 (1) ◽  
pp. 656-669 ◽  
Author(s):  
Magfur E. Alam ◽  
Thomas R. Slaney ◽  
Lina Wu ◽  
Tapan K. Das ◽  
Sambit Kar ◽  
...  
Keyword(s):  
Methionine Oxidation ◽  
Tryptophan Oxidation ◽  
Asparagine Deamidation

Re-Programming Hydrogel Properties using a Fuel-driven Reaction Cycle

2019 ◽  
Author(s):  
Nishant Singh ◽  
Bruno Lainer ◽  
Georges Formon ◽  
Serena De Piccoli ◽  
Thomas Hermans
Keyword(s):  
Methionine Oxidation ◽  
Guanosine Triphosphate ◽  
Control Reaction ◽  
Reaction Cycle ◽  
Materials Properties ◽  
Assembly Kinetics ◽  
Control Assembly ◽  
Indispensable Tool ◽  
Reaction Cycles ◽  
Non Equilibrium

Nature uses catalysis as an indispensable tool to control assembly and reaction cycles in vital non-equilibrium supramolecular processes. For instance, enzymatic methionine oxidation regulates actin (dis)assembly, and catalytic guanosine triphosphate hydrolysis is found in tubulin (dis)assembly. Here we present a completely artificial reaction cycle which is driven by a chemical fuel that is catalytically obtained from a ‘pre-fuel’. The reaction cycle controls the disassembly and re-assembly of a hydrogel, where the rate of pre-fuel turnover dictates the morphology as well as the mechanical properties. By adding additional fresh aliquots of fuel and removing waste, the hydrogels can be re-programmed time after time. Overall, we show how catalysis can control fuel generation to control reaction / assembly kinetics and materials properties in life-like non-equilibrium systems.

scholarly journals Mechanism of Calmodulin Recognition of the Binding Domain of Isoform 1b of the Plasma Membrane Ca2+-ATPase:  Kinetic Pathway and Effects of Methionine Oxidation†

Biochemistry ◽  
2007 ◽  
Vol 46 (13) ◽  
pp. 4045-4054 ◽  
Author(s):  
Brian D. Slaughter ◽  
Ramona J. Bieber Urbauer ◽  
Jeffrey L. Urbauer ◽  
Carey K. Johnson
Keyword(s):  
Plasma Membrane ◽  
Binding Domain ◽  
Methionine Oxidation

Affinity Purification and Elimination of Methionine Oxidation in Recombinant Human Cystatin C

1997 ◽  
Vol 11 (1) ◽  
pp. 111-118 ◽  
Author(s):  
Paul J. Berti ◽  
Irena Ekiel ◽  
Peter Lindahl ◽  
Magnus Abrahamson ◽  
Andrew C. Storer
Keyword(s):  
Cystatin C ◽  
Affinity Purification ◽  
Methionine Oxidation ◽  
Human Cystatin C ◽  
Human Cystatin
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