Transdermal route: A viable option for systemic delivery of antidepressants

Delivering drugs to the posterior eye has been a challenge for many years. Systemic delivery of drugs is not a viable option because the eye does not receive enough blood supply, because of its small size, for the drug delivery process to be effective. Topical delivery in the form of eye drops is also ineffective in generating therapeutic concentrations in the posterior eye, because of the resistance offered by the corneal epithelium to the transport of drugs, and rapid elimination due to aqueous humor flow and tear dilution. Intravitreal delivery of drugs through implants and injections has been associated with serious side effects like endophthalmitis, hemorrhage, and retinal detachment. In recent years, transcleral delivery of drugs has received attention due to the relatively high permeability of the sclera.

Download Full-text

532: Empirical Antibiotic Therapy in the Management of Elevated Serum PSA- A Viable Option?

The Journal of Urology ◽

10.1016/s0022-5347(18)32778-2 ◽

2006 ◽

Vol 175 (4S) ◽

pp. 172-172

Author(s):

Chee Kwan Ng ◽

Gerald Y. Tan ◽

Khai Lee Toh ◽

Sing Joo Chia ◽

James K. Tan

Keyword(s):

Antibiotic Therapy ◽

Elevated Serum ◽

Empirical Antibiotic Therapy ◽

Viable Option

Download Full-text

Decision letter for "In Vitro Maturation is a viable option for urgent fertility preservation in young women with hematological conditions"

10.1002/hon.2724/v2/decision1 ◽

2020 ◽

Keyword(s):

Fertility Preservation ◽

Young Women ◽

Viable Option

Download Full-text

Systemic Delivery of Anti-HGF Monoclonal Antibody Inhibits Glioma Growth Through Downstream Oncogenic Signaling Molecules

Planta Medica ◽

10.1055/s-2008-1075233 ◽

2008 ◽

Vol 74 (03) ◽

Author(s):

K Cornet ◽

B Lal ◽

CR Goodwin ◽

J Laterra

Keyword(s):

Monoclonal Antibody ◽

Signaling Molecules ◽

Systemic Delivery ◽

Oncogenic Signaling ◽

Glioma Growth

Download Full-text

Mobile Money - A Catalyst for Financial Inclusion in Developing Economies: A Case Study of Zimbabwe using FinScope Survey Data

GIS Business ◽

10.26643/gis.v12i4.3431 ◽

2016 ◽

Vol 12 (4) ◽

pp. 45-56

Author(s):

Kingstone Mutsonziwa ◽

Obert K. Maposa

Keyword(s):

Rural Communities ◽

Developing Economies ◽

Adult Population ◽

Financial System ◽

Financial Inclusion ◽

Viable Option ◽

Mobile Money ◽

Bank Branches ◽

Financial Transactions

Mobile money in Zimbabwe has extensively extended the frontiers of financial inclusion to reach millions who were earlier excluded within a relatively short space of time. The growing use of mobile phones in transferring money and making payments has significantly altered the countrys financial inclusion landscape as millions who had been hitherto excluded can now perform financial transactions in a relatively cheap, reliable and secure way. The FinScope results found out that 45% of the adult population use mobile money services. Of those using mobile money, 65% mentioned that is convenient, while 36% mentioned that it is cheap. Mobile money is accessible. These drivers are in the backdrop of few or no bank branches in rural communities as well as time and cost of accessing the bank branches. In Zimbabwe, mobile money is mostly used as a vehicle for remittances. While some people are enjoying mobile money services, it is important to mention that there are still people who are excluded from the formal financial system. The reasons why people do not use mobile money are mainly related to poverty issues. Mobile money remains a viable option to push the landscape of financial inclusion in Zimbabwe and other emerging markets where the formal financial system might not be strong.

Download Full-text

Pharmacokinetic peculiarities of drugs used in the form of rapidly dispersible tablets (oral delivery system)

10.33920/med-13-2001-01 ◽

2020 ◽

pp. 7-24

Author(s):

Zhanna Kozlova ◽

Ivan Krasnyuk ◽

Yuliya Lebedeva ◽

Ekaterina Odintsova

Keyword(s):

Oral Mucosa ◽

Oral Delivery ◽

Chemical Properties ◽

Rapid Onset ◽

Systemic Circulation ◽

Systemic Delivery ◽

Onset Of Action ◽

Mucosal Drug Delivery ◽

Physical And Chemical ◽

Pass Metabolism

Oral mucosal drug delivery is an alternative method of systemic delivery with several advantages over both injectable and enteral methods. Drugs that are absorbed through the oral mucosa directly enter the systemic circulation, passing through the gastrointestinal tract and first-pass metabolism in the liver due to oral mucosa being highly vascularised. This results in rapid onset of action for some drugs because of a more comfortable and convenient way of delivery than the intravenous one. But not all drugs can be administered through the oral mucosa due to characteristics of the oral mucosa and physical and chemical properties of the drug.

Download Full-text