“Simple febrile seizures plus (SFS+)”: More than one febrile seizure within 24hours is usually okay

2013 ◽  
Vol 27 (3) ◽  
pp. 472-476 ◽  
Author(s):  
Marie F. Grill ◽  
Yu-Tze Ng
Keyword(s):  
Febrile Seizure ◽  
Febrile Seizures ◽  
Febrile Seizures Plus

scholarly journals Pattern of Electroencephalography in Recurrent Febrile Seizure Patient

2019 ◽  
Vol 3 (12) ◽  
pp. 471-474
Author(s):  
Adinda Chairunnisa ◽  
Prastiya Indra Gunawan ◽  
Isti Suharjanti
Keyword(s):  
Medical Record ◽  
Febrile Seizure ◽  
Pediatric Population ◽  
Febrile Seizures ◽  
Simple Complex ◽  
Abnormal Result ◽  
Prolonged Effect ◽  
Febrile Seizures Plus ◽  
Descriptive Method ◽  
Eeg Pattern

Background: Febrile seizures are seizures that often occur in children, usually of a non-hazardous nature and do not have a prolonged effect. Febrile seizures most often occur in children under five years of age and are reported to occur in 2-5% of the pediatric population. Febrile seizures are categorized as simple, complex and plus febrile seizures. In some patients, EEG is needed to ascertain whether a true febrile seizure occurs. Objective: This study aims to determine the EEG pattern in recurrent febrile seizure patients at the Child Inpatient Installation of Dr. Soetomo Surabaya. Method: This study used a retrospective descriptive method with medical record instruments. Results: This study showed that of 46 recurrent febrile seizures, only 21 patients could see the EEG results. Of the 18 patients with complicated febrile seizures there were 27.78% abnormal and 72.22% normal. One simple febrile seizure patient obtained a normal EEG result. Of the two patients with febrile seizures plus 50% abnormal results and 50% normal results. Conclusions: The EEG pattern in patients with recurring complex febrile seizure obtains the most abnormal result. Keywords: recurrent febrile seizure; electroencephalography; prevalence

Identification of a Novel Nonsense Variant in the SCN1A Gene that Causes Febrile Seizure Disorder

2017 ◽  
Vol 16 (04) ◽  
pp. 236-238
Author(s):  
Nabila MarchoudI ◽  
Abdelfettah Rouissi ◽  
Jamal Fekkak ◽  
Farah Jouali
Keyword(s):  
Febrile Seizure ◽  
Febrile Seizures ◽  
Seizure Disorder ◽  
Gene Encoding ◽  
Seizure Disorders ◽  
Severe Myoclonic Epilepsy ◽  
Epilepsy Gene ◽  
Generalized Epilepsy ◽  
Febrile Seizures Plus ◽  
Scn1a Gene

AbstractThe SCN1A gene, encoding for the voltage-gated sodium channel Nav1.1, is the most clinically relevant epilepsy gene, with most mutations having been documented in a spectrum of epilepsy syndromes, ranging from the relatively benign generalized epilepsy with febrile seizures plus (GEFS+) to severe myoclonic epilepsy in infancy (SMEI), and other rare febrile seizure disorders. To date, more than 1,250 mutations in SCN1A have been linked to epilepsy. In this case, we describe a novel nonsense pathogenic variant (NM_001202435.1; c.327C > G) in SCN1A in a 10-month Moroccan infant with febrile seizure disorder.

scholarly journals Genetic epilepsy with febrile seizures plus – an overview

2021 ◽  
Vol 20 (1) ◽  
pp. 21-27
Author(s):  
Madalina Radu ◽  
◽  
Eugenia Roza ◽  
Daniel Mihai Teleanu ◽  
Raluca Ioana Teleanu ◽  
...  
Keyword(s):  
Febrile Seizure ◽  
De Novo ◽  
Febrile Seizures ◽  
Alpha Subunit ◽  
Gamma Aminobutyric Acid ◽  
Voltage Gated ◽  
Genetic Epilepsy ◽  
Generalized Seizures ◽  
Gated Channel ◽  
Febrile Seizures Plus

Genetic epilepsy with febrile seizures plus (GEFS+) is characterized by a group of genetic epilepsies associated predominately with an autosomal dominant pattern, but also with de novo and autosomal-recessive inheritance, these last two found in a small number of cases. It was believed that GEFS+ is associated only with generalized seizures, but now the term “genetic epilepsy” is preferred because it has been demonstrated that GEFS+ is associated with both generalized and focal seizures. The “GEFS+ family” was defined as a family with more than two individuals with GEFS+ phenotypes, including at least one with febrile seizure or febrile seizure plus. The GEFS+ spectrum includes febrile seizures (FS), febrile seizures plus (FS+), myoclonic seizures, myoclonic-atonic seizures, absences seizures, focal or generalized seizures. The genetic mutations responsible for inhibitor-excitatory imbalance in neurons network were found in sodium voltage-gated channel alpha subunit 1 (SCN1A), sodium voltage-gated channel beta subunit 1 (SCN1B), sodium voltage-gated channel alpha subunit 2 (SCN2A), sodium voltage-gated channel alpha subunit 9 (SCN9A), gamma-aminobutyric acid type A receptor subunit gamma 2 (GABRG2), which are the main gene in GEFS+ genotype.

Mutation screening of three Chinese families with genetic epilepsy with febrile seizures plus

2011 ◽  
Vol 500 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Hua Lin ◽  
Jingyun Li ◽  
Mengyang Wang ◽  
Zheng Wang ◽  
Yuping Wang ◽  
...  
Keyword(s):  
Mutation Screening ◽  
Febrile Seizures ◽  
Chinese Families ◽  
Genetic Epilepsy ◽  
Febrile Seizures Plus

Just Say No!

PEDIATRICS ◽  
1990 ◽  
Vol 86 (4) ◽  
pp. 624-624
Author(s):  
JOHN M. FREEMAN
Keyword(s):  
Febrile Seizure ◽  
Febrile Seizures ◽  
National Institutes Of Health ◽  
Consensus Development ◽  
Consensus Development Conference ◽  
Focal Seizures ◽  
The Family ◽  
History Of ◽  
Neurologic Development

A seizure, even a febrile seizure, is terrifying to the family. Seeking reassurance that their child will not die and does not have epilepsy, parents turn to their physician. What is he or she to do? Often the physician prescribes medication "to prevent further seizures" and then reassures the family that the child will be fine if the medicine is given daily as directed. Both the recommendation and the reassurance are wrong. A Consensus Development Conference on Febrile Seizures held by the National Institutes of Health in 19801 concluded that they would only "consider" anticonvulsant prophylaxis when the child (1) had abnormal neurologic development, (2) had long or focal seizures, (3) had more than two seizures in 24 hours, (4) had a history of nonfebrile seizures in parent or sibling, or (5) was younger than 1 years of age.

The Association between Serum Sodium Levels and Febrile Seizures Recurrence: Is the Degree of Hyponatremia a Risk Factor?

2021 ◽  
Author(s):  
Esma Keleş Alp ◽  
Ahmet Midhat Elmacı
Keyword(s):  
Serum Sodium ◽  
Medical Records ◽  
Febrile Seizure ◽  
Serum Sodium Level ◽  
Febrile Seizures ◽  
Lower Sensitivity ◽  
Operating Characteristics ◽  
Serum Electrolyte ◽  
Optimal Cutoff ◽  
Characteristics Analysis

AbstractFebrile seizures are common disorders in childhood. We evaluated the serum electrolyte levels and the associated factors in children with single and recurrent febrile seizures in 24 hours period of hospitalization. The medical records of children who were clinically diagnosed with febrile seizures and hospitalized were retrospectively revealed and analyzed. Data were collected for children aged 1 to 6 years including demographic parameters and serum electrolyte levels. A total of 244 children were enrolled in the study in which 209 were diagnosed with single febrile seizures and 35 of them with recurrent febrile seizures. Serum sodium levels were significantly lower in children with recurrent febrile seizure (138.5 ± 2.38 and 134.2 ± 3.55, p < 0.001). Correlation analysis revealed that mild hyponatremia is associated with recurrence of febrile seizure within 24 hours. However, receiver-operating characteristics analysis for hyponatremia showed lower sensitivity (50.3%) and specificity (43.1%) values for optimal cutoff value of 133.5 mmol/L of serum sodium level. Our study suggested that serum sodium levels were significantly lower in children with recurrent febrile seizures. However, because of its lower sensitivity and specificity values, mild hyponatremia cannot be used as an indicator for febrile seizure recurrence.

GAMBARAN TINGKAT KECEMASAN ORANG TUA TERHADAP HOSPITALISASI ANAK DENGAN KEJANG DEMAM SELAMA ANAK DI RAWAT DI RUMAH SAKIT SANTA ELISABETH MEDAN TAHUN 2017

2017 ◽  
Vol 2 (2) ◽  
pp. 53-60
Author(s):  
Melky Rismando Damanik ◽  
Rusmauli Lumban Gaol
Keyword(s):  
Data Analysis ◽  
Febrile Seizure ◽  
Febrile Seizures ◽  
Anxiety Level ◽  
Parental Anxiety ◽  
Subjective Experiences ◽  
High Anxiety ◽  
Specific Object ◽  
Anxiety Levels ◽  
The Individual

Anxiety is an unclear and widespread concern, associated with feelings of uncertainty and helplessness. This state of anxiety and emotion has no specific object but can affect behavior toward parents whose children are hospitalized. Parental anxiety levels are subjective experiences of the individual and can not be directly observed but consequently will affect the anxiety level of the parent. Hospitalization of children is a state of crisis in children, when children are sick and hospitalized, one of them in the febrile seizure disease is a seizure spasm that occurs in the rise in body temperature above 38 ° C this will result in anxiety level of parents increases. Goals: To know the description of anxiety level of parent to hospitalization of child with febrile seizure during child is treated in hospital of Elisabeth Elisabeth Medan. Method: The design used in this study is descriptive to describe the level of anxiety parents to hospitalization of children with febrile seizures during child care at Hospital Santa Elisabeth Medan Year 2017. Result: based on data collection found 10 respondents where 5 (50%) of respondents who experienced anxiety level in medium category and 5 (50%) respondents have low level anxiety level. Conclusion: Based on the research and data analysis that has been done in accordance with the objectives that have been determined can be concluded that all parents who care for their children in the hospital will experience anxiety level that is 5 respondents (50%) with moderate anxiety level, while 5 others (50% Low anxiety levels and high anxiety levels were not found.

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