Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production

2016 ◽  
Vol 340 (2) ◽  
pp. 315-326 ◽  
Author(s):  
Junli Ye ◽  
Zhongxin Jiang ◽  
Xuehong Chen ◽  
Mengyang Liu ◽  
Jing Li ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Electron Transport ◽  
Electron Transport Chain ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Microglia Activation ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Transport Chain ◽  
Species Production

Possible role of free oxidation processes in the regulation of reactive oxygen species production in plant mitochondria

2003 ◽  
Vol 31 (6) ◽  
pp. 1316-1317 ◽  
Author(s):  
V.N. Popov
Keyword(s):  
Reactive Oxygen Species ◽  
Electron Transport ◽  
Electron Transport Chain ◽  
Plant Mitochondria ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Oxidation Processes ◽  
Transport Chain ◽  
Electron Reduction ◽  
Species Production

The non-coupled substrate oxidation mediated by components of the electron transport chain that are not coupled to energy accumulation (such as plant alternative oxidase and rotenone-insensitive NADH dehydrogenases) and uncoupled respiration are peculiar features of plant mitochondria. The physiological significance of such energy-wasting oxidation processes is still debated. It is proposed that non-coupled oxidation could regulate the level of reduction of components of the electron transport chain and the rate of one-electron reduction of oxygen, thereby affecting the rate of formation of reactive oxygen species.

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