Attempts to activate a pubertal pattern of GnRH release in juvenile male rhesus monkeys (Macaca mulatta) with continuous low dose infusions of human metastin 45–54

2006 ◽  
Vol 27 (1) ◽  
pp. 140
Author(s):  
Meloni J. DiPietro ◽  
Suresh Ramaswamy ◽  
Stephanie B. Seminara ◽  
William F. Crowley Jr. ◽  
Tony M. Plant
2022 ◽  
Vol 137 ◽  
pp. 105078
Author(s):  
Sally B. Seraphin ◽  
Mar M. Sanchez ◽  
Patricia L. Whitten ◽  
James T. Winslow

Author(s):  
A.M. Andrews ◽  
S.W. Wilson ◽  
A.C. Scallet ◽  
S.F. Ali ◽  
J. Bailey ◽  
...  

Exposure of rhesus monkeys (Macaca mulatta) to marijuana via inhalation or to intravenous delta-9-tetrahydrocannabinol (THC), reportedly caused ultrastructural evidence of increased synaptic width. Chronic marijuana smoke in a single rhesus monkey examined after a six month withdrawal time caused ultrastructure changes in the septal, hippocampal and amygdala regions; the synaptic cleft was widened, electron opaque material was found in the cleft and in the pre- and postsynaptic regions, with some clumping of the synaptic vesicles. The objective of our study was to assess neuropathological alterations produced by chronic inhalation of marijuana smoke.Nineteen male rhesus monkeys, 3-5 years of age and weighing 3-8 kg, were divided into four treatment groups: a) sham control, b) placebo smoke (7 days/ week) c) low dose marijuana (2 times/week with 5 days/week sham) and d) high dose marijuana (7 times/week). A smoke exposure consisted of smoke from one cigarette (2.6% THC) burned down to 10 mm butt length. Smoke was administered via smoke generator (ADL II, Arthur D. Little, Inc. Cambridge, MA) and nose-mouth only masks (local production) equipped with one-way valves.


The work of Collings (1926), Allen (1927, 1928), Morrell (1930), and Parkes and Zuckerman (1931) on rhesus monkeys has established the fact that the brilliant coloration of the skin about the genitalia and the face, loosely referred to as the sex skin, and seen in both the female and male of this species, can be called forth by the administration of œstrous-producing hormone. Parkes and Zuckerman could not produce it in the case of one castrate male rhesus and a castrate female bonnet monkey. M. radiata , but they obtained in an ovariectomized baboon the full swelling seen during the follicular phase, and Dohrn, Hohlweg and Schoeller (1932, 1933) working with both male and female baboons and employing crystalline “ progynon,” were uniformly successful in eliciting a reaction, which in the male specimens of this species consisted of a remarkable œdema of the genitalia. In the present paper we should like to report our own experiments concerning this particular skin reaction to œstriol. Material and Technique Eight macaques, including one immature and four adolescent animals, were studied. Of the total, five were normal animals, four of these being males. The remaining three comprised one castrate male and two hypophysectomized-castrate females.


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