Human herpesvirus-8–associated disseminated angiosarcoma in an HIV-seronegative woman: report of a case and limited case-control virologic study in vascular tumors

2000 ◽  
Vol 108 (8) ◽  
pp. 660-664 ◽  
Author(s):  
Scot C Remick ◽  
Madhumita Patnaik ◽  
Navid M Ziran ◽  
Karsten R Liegmann ◽  
Jennifer Dong ◽  
...  
Keyword(s):  
Human Herpesvirus ◽  
Case Control ◽  
Human Herpesvirus 8 ◽  
Vascular Tumors ◽  
Herpesvirus 8 ◽  
Seronegative Woman

scholarly journals Risk of malignant lymphoma associated with human herpesvirus-8: a case–control study in Spain

2004 ◽  
Vol 90 (11) ◽  
pp. 2145-2148 ◽  
Author(s):  
S de Sanjosé ◽  
J J Goedert ◽  
V Marshall ◽  
C Bellas ◽  
Y Benavente ◽  
...  
Keyword(s):  
Malignant Lymphoma ◽  
Case Control Study ◽  
Human Herpesvirus ◽  
Case Control ◽  
Human Herpesvirus 8 ◽  
Herpesvirus 8 ◽  
Control Study

scholarly journals Transgenic Expression of the Chemokine Receptor Encoded by Human Herpesvirus 8 Induces an Angioproliferative Disease Resembling Kaposi's Sarcoma

2000 ◽  
Vol 191 (3) ◽  
pp. 445-454 ◽  
Author(s):  
Tong-Yuan Yang ◽  
Shu-Cheng Chen ◽  
Michael W. Leach ◽  
Denise Manfra ◽  
Bernhard Homey ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Kaposi's Sarcoma ◽  
Human Herpesvirus ◽  
Kaposi’S Sarcoma ◽  
Inflammatory Cells ◽  
Etiologic Agent ◽  
Human Herpesvirus 8 ◽  
Vascular Tumors ◽  
Transgenic Expression ◽  
Herpesvirus 8

Human herpesvirus 8 (HHV8, also known as Kaposi's sarcoma [KS]-associated herpesvirus) has been implicated as an etiologic agent for KS, an angiogenic tumor composed of endothelial, inflammatory, and spindle cells. Here, we report that transgenic mice expressing the HHV8-encoded chemokine receptor (viral G protein–coupled receptor) within hematopoietic cells develop angioproliferative lesions in multiple organs that morphologically resemble KS lesions. These lesions are characterized by a spectrum of changes ranging from erythematous maculae to vascular tumors, by the presence of spindle and inflammatory cells, and by expression of vGPCR, CD34, and vascular endothelial growth factor. We conclude that vGPCR contributes to the development of the angioproliferative lesions observed in these mice and suggest that this chemokine receptor may play a role in the pathogenesis of KS in humans.

Absence of human herpesvirus 8 DNA sequences in vascular tumors of the liver*

2008 ◽  
Vol 18 (2) ◽  
pp. 124-127 ◽  
Author(s):  
Kamal G. Ishak ◽  
Karen E. Bijwaard ◽  
Hala R. Makhlouf ◽  
Jeffery K. Taubenberger ◽  
Jack H. Lichy ◽  
...  
Keyword(s):  
Dna Sequences ◽  
Human Herpesvirus ◽  
Human Herpesvirus 8 ◽  
Vascular Tumors ◽  
Herpesvirus 8 ◽  
Tumors Of The Liver
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