Spontaneous ovarian hyperstimulation syndrome concomitant with spontaneous pregnancy in a woman with polycystic ovary disease

1992 ◽  
Vol 167 (1) ◽  
pp. 122-124 ◽  
Author(s):  
Yaron Zalel ◽  
Zvi Katz ◽  
Benjamin Caspi ◽  
Herzel Ben-Hur ◽  
Rami Dgani ◽  
...  
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Polycystic Ovary ◽  
Ovarian Hyperstimulation ◽  
Spontaneous Pregnancy

scholarly journals Spontaneous Pregnancy with Severe Ovarian Hyperstimulation Syndrome Undergoing IVF-ET Cycle: A Case Report and Review

2020 ◽  
Author(s):  
Chaonan Peng ◽  
Zhixiao Wang
Keyword(s):  
Embryo Transfer ◽  
Ovarian Hyperstimulation Syndrome ◽  
Induction Treatment ◽  
Ovarian Hyperstimulation ◽  
Self Healing ◽  
Spontaneous Pregnancy ◽  
Severe Ovarian Hyperstimulation Syndrome ◽  
Severe Ohss ◽  
Ivf Et

Abstract It is relatively rare that a natural spontaneous with severe ovarian hyperstimulation syndrome (OHSS) occurs undergoing in vitro fertilization and embryo transfer (IVF-ET).Pregnancy can cause OHSS to be delayed, and even lead to pregnancy loss in severe cases.In this case, we introduced the case of a 32-year-old female infertile patient with PCOS who underwent IVF-ET cycle and developed severe OHSS before embryo transfer. After volume expansion, symptomatic and supportive treatment and four times of abdominal puncture to extract ascites, the patient's condition is still protracted.However, interestingly, two weeks after giving up treatment, the patient found a spontaneous pregnancy and ended up with biochemical pregnancy. Severe OHSS was also gradually self-healing after biochemical pregnancy.This case emphasizes that pregnancy is one of the high-risk factors of OHSS, which can lead to the delay of the patient's condition with OHSS. Clinicians should be alert to the possibility of spontaneous pregnancy when they take luteal phase ovulation induction treatment undergoing IVF-ET cycle.

scholarly journals Spontaneous ovarian hyperstimulation syndrome in a nonpregnant female patient: a case report and literature review

2020 ◽  
Vol 48 (9) ◽  
pp. 030006052095264
Author(s):  
Wei Chai ◽  
Hongyu He ◽  
Fei Li ◽  
Wenlei Zhang ◽  
Chao He
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Polycystic Ovary ◽  
Wedge Resection ◽  
Receptor Gene ◽  
Abdominal Distension ◽  
Abdominal Ultrasound ◽  
Symptomatic Treatment ◽  
Carbohydrate Antigen ◽  
Ovarian Hyperstimulation ◽  
Carbohydrate Antigen 125

Spontaneous ovarian hyperstimulation syndrome (sOHSS) usually occurs in patients with a spontaneous ovulation cycle, especially in those with multiple pregnancies combined with hypothyroidism and polycystic ovary syndrome. sOHSS rarely occurs in women who are not pregnant. A 23-year-old woman with obvious abdominal distension visited our hospital. The patient was not pregnant and had not undergone controlled superovulation. Apart from abdominal distension, the patient denied any symptom of obvious incentives, abdominal pain, abnormal vaginal bleeding, or drainage. Biochemical analysis showed a high carbohydrate antigen-125 level and low total protein and albumin levels. Abdominal ultrasound and computed tomography showed a large amount of ascites and cystic uneven masses with an irregular shape in the area of the ovaries and fallopian tubes. Post-surgical histopathology indicated the diagnosis of sOHSS. Wedge resection of both ovaries was performed. Symptomatic treatment was further performed and the patient recovered well. Our findings indicate that sOHSS can occur in women who are not pregnant. Additionally, besides the follicle-stimulating hormone receptor gene mutation hypothesis, the pathogenesis of sOHSS should be further studied.

Targeting angiogenesis in the pathological ovary

2013 ◽  
Vol 25 (2) ◽  
pp. 362 ◽  
Author(s):  
W. Colin Duncan ◽  
Junko Nio-Kobayashi
Keyword(s):  
Ovarian Hyperstimulation Syndrome ◽  
Therapeutic Potential ◽  
Polycystic Ovary ◽  
Ovarian Hyperstimulation ◽  
Vascular Endothelial ◽  
Theoretical Possibility ◽  
Clinical Role ◽  
And Function ◽  
Endothelial Growth Factor

The ovary is a key tissue in the study of physiological neo-vascularisation in the adult and its study has highlighted important molecules involved in the regulation of angiogenesis in vivo. These include vascular endothelial growth factor, delta-like ligand 4, thrombospondin-1, prokineticin-1 and prostaglandin E2. Targeting these molecular pathways has therapeutic potential and their manipulation has an increasing preclinical and clinical role in the management of the pathological ovary. Targeting angiogenic pathways has utility in the promotion of ovarian angiogenesis to improve tissue and follicle survival and function as well as the prevention and management of ovarian hyperstimulation syndrome. There is a theoretical possibility that targeting angiogenesis may improve the function of the polycystic ovary and a real role for targeting angiogenesis in ovarian cancer.

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