Clinical features and prognosis of Miller Fisher syndrome. Mori M,∗∗Department of Neurology, Chiba University School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670 Japan. E-mail: [email protected] Kuwabara S, Fukutake T, Yuki N, Hattori T. Neurology 2001;56:1104–1106.

2001 ◽  
Vol 132 (3) ◽  
pp. 456
Author(s):  
Thomas J Liesegang
Keyword(s):  
Clinical Features ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
School Of Medicine ◽  
E Mail

scholarly journals Miller-Fisher Syndrome: Are Anti-GAD Antibodies Implicated in Its Pathophysiology?

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Ioannis E. Dagklis ◽  
Sotirios Papagiannopoulos ◽  
Varvara Theodoridou ◽  
Dimitrios Kazis ◽  
Ourania Argyropoulou ◽  
...  
Keyword(s):  
Clinical Features ◽  
Gamma Globulin ◽  
Miller Fisher Syndrome ◽  
Acid Decarboxylase ◽  
Gad Antibodies ◽  
Fisher Syndrome ◽  
Future Studies ◽  
Neurological Improvement ◽  
Intravenous Gamma Globulin

Miller-Fisher syndrome (MFS) is considered as a variant of the Guillain-Barre syndrome (GBS) and its characteristic clinical features are ophthalmoplegia, ataxia, and areflexia. Typically, it is associated with anti-GQ1b antibodies; however, a significant percentage (>10%) of these patients are seronegative. Here, we report a 67-year-old female patient who presented with the typical clinical features of MFS. Workup revealed antibodies against glutamic acid decarboxylase (GAD) in relatively high titers while GQ1b antibodies were negative. Neurological improvement was observed after intravenous gamma globulin and follow-up examinations showed a continuous clinical amelioration with simultaneous decline of anti-GAD levels which finally returned to normal values. This case indicates that anti-GAD antibodies may be associated with a broader clinical spectrum and future studies in GQ1b-seronegative patients could determine ultimately their clinical and pathogenetic significance in this syndrome.

Clinical features and prognosis of Miller Fisher syndrome

Neurology ◽  
2001 ◽  
Vol 56 (8) ◽  
pp. 1104-1106 ◽  
Author(s):  
M. Mori ◽  
S. Kuwabara ◽  
T. Fukutake ◽  
N. Yuki ◽  
T. Hattori
Keyword(s):  
Clinical Features ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome

scholarly journals Miller Fisher Syndrome: a case report

2017 ◽  
Vol 4 (4) ◽  
pp. 1193
Author(s):  
Shubhransu Patro ◽  
Vipin S. ◽  
Pankaj K. Khora ◽  
Payod K. Jena
Keyword(s):  
Case Report ◽  
Clinical Diagnosis ◽  
Clinical Features ◽  
Antibody Titer ◽  
Conservative Management ◽  
Recovery Phase ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
Positive Serum ◽  
History Of

Miller Fisher Syndrome (MFS) is an uncommon variant of Guillain Barre syndrome (GBS). It is largely a clinical diagnosis based on the cardinal clinical features of ophthalmoplegia, ataxia and areflexia. The following case report is that of a patient who presented with an acute history of reeling of head, difficulty in opening the eyelids and swaying while walking, on clinical examination revealed the above-mentioned cardinal features and on investigation showed positive serum anti GQ1b antibody titer. The patient started recovering with conservative management and was discharged in the recovery phase.

scholarly journals Structure of Campylobacter jejuni Lipopolysaccharides Determines Antiganglioside Specificity and Clinical Features of Guillain-Barré and Miller Fisher Patients

2002 ◽  
Vol 70 (3) ◽  
pp. 1202-1208 ◽  
Author(s):  
C. W. Ang ◽  
J. D. Laman ◽  
H. J. Willison ◽  
E. R. Wagner ◽  
H. P. Endtz ◽  
...  
Keyword(s):  
Risk Factor ◽  
Antibody Response ◽  
Campylobacter Jejuni ◽  
Clinical Features ◽  
Miller Fisher Syndrome ◽  
Fisher Syndrome ◽  
Antibody Reactivity ◽  
Strong Antibody Response ◽  
Almost All

ABSTRACT Ganglioside mimicry in the lipopolysaccharide (LPS) fraction of Campylobacter jejuni isolated from Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) patients was compared with isolates from patients with an uncomplicated enteritis. The antibody response to C. jejuni LPS and gangliosides in neuropathy patients and controls was compared as well. LPS from GBS and MFS-associated isolates more frequently contained ganglioside-like epitopes compared to control isolates. Almost all neuropathy patients showed a strong antibody response against LPS and multiple gangliosides in contrast to enteritis patients. Isolates from GBS patients more frequently had a GM1-like epitope than isolates from MFS patients. GQ1b-like epitopes were present in all MFS-associated isolates and was associated with anti-GQ1b antibody reactivity and the presence of oculomotor symptoms. These results demonstrate that the expression of ganglioside mimics is a risk factor for the development of post-Campylobacter neuropathy. This study provides additional evidence for the hypothesis that the LPS fraction determines the antiganglioside specificity and clinical features in post-Campylobacter neuropathy patients.

scholarly journals Clinical Features of Miller-Fisher Syndrome in Pregnancy

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Masanori Ono ◽  
Hideki Sato ◽  
Mayu Shirahashi ◽  
Noriko Tomioka ◽  
Julia Maeda ◽  
...  
Keyword(s):  
Clinical Features ◽  
Pregnant Patient ◽  
Acute Onset ◽  
Accurate Diagnosis ◽  
Miller Fisher Syndrome ◽  
The West ◽  
Fisher Syndrome ◽  
Brainstem Stroke ◽  
Clinical Triad ◽  
Patient’S History

Miller-Fisher syndrome (MFS) is recognized as a variant of Guillain-Barré syndrome (GBS). MFS is a rare disorder that is characterized by the acute onset of ophthalmoplegia, ataxia, and areflexia/hyporeflexia. MFS has a higher incidence in Asia, where the incidence is estimated to be 18%–26% of GBS compared with 3%–5% in the West. The differential diagnosis of MFS includes Wernicke’s encephalopathy (WE) which is characterized by a clinical triad (nystagmus and ophthalmoplegia, mental status changes, and ataxia), myasthenia gravis, and brainstem stroke. The association between MFS and pregnancy has not been reported previously. Here, we describe the clinical features of a pregnant woman in early pregnancy with MFS. This case highlights the fact that it is necessary to establish an accurate diagnosis based on the details from the patient’s history on appropriate complementary testing in a pregnant patient with MFS.

Sign in / Sign up

Export Citation Format

Share Document